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Operating Expenses (Tables) | 12 Months Ended
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Dec. 31, 2017
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Summary of Research and Development Expense | The research and development expenses are broken down as follows:
|  | December 31, |
Research and development expenses |  | 2015 |  |  | 2016 |  |  | 2017 |
|  | (thousands of Euros) |
Personnel expenses |  |  | 13,268 |  |  |  | 32,777 |  |  |  | 37,112 |
Sub-contracting, collaboration, and consultants |  |  | 15,325 |  |  |  | 34,413 |  |  |  | 54,397 |
Research supplies |  |  | 911 |  |  |  | 1,234 |  |  |  | 1,464 |
Rental |  |  | 1,094 |  |  |  | 1,903 |  |  |  | 2,018 |
Conferences, travel expenses |  |  | 1,233 |  |  |  | 2,387 |  |  |  | 2,807 |
Depreciation and amortization |  |  | 1,000 |  |  |  | 1,141 |  |  |  | 2,424 |
Small equipments and other supplies |  |  | 795 |  |  |  | 2,675 |  |  |  | 2,646 |
Others |  |  | 608 |  |  |  | 2,298 |  |  |  | 2,364 |
Total research and development expenses |  |  | 34,234 |  |  |  | 78,828 |  |  |  | 105,232 |
Summary of Sales And Marketing Expense | The sales and marketing expenses are broken down as follows:
|  | December 31, |
Sales and marketing expenses |  | 2015 |  |  | 2016 |  |  | 2017 |
|  | (thousands of Euros) |
Personnel expenses |  |  | 133 |  |  |  | 4,954 |  |  |  | 6,976 |
Fees |  |  | 339 |  |  |  | 4,447 |  |  |  | 2,480 |
Marketing, tradeshows and travel expenses |  |  | 20 |  |  |  | 1,393 |  |  |  | 5,984 |
Others |  |  | — |  |  |  | 487 |  |  |  | 384 |
Total sales and marketing expenses |  |  | 491 |  |  |  | 11,282 |  |  |  | 15,824 |
Summary of General and Administrative Expense | By nature, the breakdown of general and administrative expenses is as follows:
|  | December 31, |
General and administrative expenses |  | 2015 |  |  | 2016 |  |  | 2017 |
|  | (thousands of Euros) |
Personnel expenses |  |  | 8,768 |  |  |  | 22,613 |  |  |  | 19,742 |
Fees |  |  | 4,234 |  |  |  | 7,701 |  |  |  | 10,347 |
Rental |  |  | 305 |  |  |  | 501 |  |  |  | 584 |
Insurance policies |  |  | 1,239 |  |  |  | 1,853 |  |  |  | 1,367 |
Corporate communication and travel expenses |  |  | 1,010 |  |  |  | 1,136 |  |  |  | 1,599 |
Depreciation and amortization |  |  | 74 |  |  |  | 181 |  |  |  | 422 |
Others |  |  | 1,229 |  |  |  | 1,020 |  |  |  | 1,776 |
Total general and administrative expenses |  |  | 16,859 |  |  |  | 35,005 |  |  |  | 35,837 |
Summary of Personnel Expense | The personnel expenses are broken down as follows:
|  | December 31, |
|  | 2015 |  |  | 2016 |  |  | 2017 |
|  | (thousands of Euros) |
Wages and salaries |  |  | 7,243 |  |  |  | 14,651 |  |  |  | 22,451 |
Social security contributions |  |  | 3,193 |  |  |  | 3,903 |  |  |  | 7,157 |
Expenses for pension commitments |  |  | 116 |  |  |  | 982 |  |  |  | 1,583 |
Employer contribution to bonus shares |  |  | 1,198 |  |  |  | 6,456 |  |  |  | 1,857 |
Share-based payments |  |  | 10,419 |  |  |  | 34,353 |  |  |  | 30,781 |
Total |  |  | 22,168 |  |  |  | 60,345 |  |  |  | 63,830 |

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