<SEC-DOCUMENT>0001193125-22-219746-index.html : 20220812
<SEC-HEADER>0001193125-22-219746.hdr.sgml : 20220812
<ACCEPTANCE-DATETIME>20220812133220
ACCESSION NUMBER:		0001193125-22-219746
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20220812
DATE AS OF CHANGE:		20220812

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Silence Therapeutics plc
		CENTRAL INDEX KEY:			0001479615
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-260265
		FILM NUMBER:		221159207

	BUSINESS ADDRESS:	
		STREET 1:		72 HAMMERSMITH ROAD
		CITY:			LONDON
		STATE:			X0
		ZIP:			W14 8TH
		BUSINESS PHONE:		44-0-20-3457 6900

	MAIL ADDRESS:	
		STREET 1:		72 HAMMERSMITH ROAD
		CITY:			LONDON
		STATE:			X0
		ZIP:			W14 8TH
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>d329562d424b5.htm
<DESCRIPTION>424B5
<TEXT>
Document 1 - file: d329562d424b5.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>g329562g36q65.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: g329562g36q65.jpg

</DOCUMENT>
</SEC-DOCUMENT>