<SEC-DOCUMENT>0000908834-24-000084.txt : 20240214
<SEC-HEADER>0000908834-24-000084.hdr.sgml : 20240214
<ACCEPTANCE-DATETIME>20240214095429
ACCESSION NUMBER:		0000908834-24-000084
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20240214
DATE AS OF CHANGE:		20240214

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Silence Therapeutics plc
		CENTRAL INDEX KEY:			0001479615
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-92205
		FILM NUMBER:		24633352

	BUSINESS ADDRESS:	
		STREET 1:		72 HAMMERSMITH ROAD
		CITY:			LONDON
		STATE:			X0
		ZIP:			W14 8TH
		BUSINESS PHONE:		44-0-20-3457 6900

	MAIL ADDRESS:	
		STREET 1:		72 HAMMERSMITH ROAD
		CITY:			LONDON
		STATE:			X0
		ZIP:			W14 8TH

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Lombard Odier Asset Management (USA) Corp
		CENTRAL INDEX KEY:			0001491719
		ORGANIZATION NAME:           	
		IRS NUMBER:				061603711
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		452 FIFTH AVENUE, 25TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10018
		BUSINESS PHONE:		212-295-6200

	MAIL ADDRESS:	
		STREET 1:		452 FIFTH AVENUE, 25TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10018
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>sln_13ga.htm
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Barnes & Thornburg
         Document created using Broadridge PROfile 23.12.1.5186
         Copyright 1995 - 2024 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <table cellspacing="0" cellpadding="0" id="zd74cc50622184c7fbce8ec27133747f8" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 70.43%; vertical-align: top;">&#160;</td>
          <td style="width: 29.57%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 70.43%; vertical-align: top;">&#160;</td>
          <td style="width: 29.57%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div style="text-align: center; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-weight: bold;">Washington, DC&#160; 20549</div>
    <div><br>
    </div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">SCHEDULE 13G</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Under the Securities Exchange Act of 1934</div>
    <div style="text-align: center; font-weight: bold;">(Amendment No. 3)&#160;&#160;&#160;<sup style="font-family: Symbol, serif; vertical-align: text-top; line-height: 1; font-size: smaller;">*</sup></div>
    <div><br>
    </div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z2fc68cb23247429cb2b15853c14e56c6" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">Silence Therapeutics plc</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; font-size: 8pt;">(Name of Issuer)</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">Ordinary Shares, par value &#163;0.05 per share</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; font-size: 8pt;">(Title of Class of Securities)</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">G8128Y157</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; font-size: 8pt;">(Cusip Number)</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">December 31, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; font-size: 8pt;">(Date of Event which Requires Filing of this Statement)</div>
            <div>&#160;</div>
          </td>
        </tr>

    </table>
    <div>Check the appropriate box to designate the rule pursuant to which this Schedule is filed:</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z24e9ace37b5d47148b47a0afef7519b8" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 4.48%; vertical-align: top;">&#160;</td>
          <td style="width: 4.59%; vertical-align: middle;">
            <div style="font-family: 'Segoe UI Symbol', sans-serif; font-size: 12pt;">&#9744;</div>
          </td>
          <td style="width: 90.93%; vertical-align: middle;">
            <div style="font-size: 12pt;">Rule 13d-1(b)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 4.48%; vertical-align: top;">&#160;</td>
          <td style="width: 4.59%; vertical-align: middle;">
            <div style="font-family: 'Segoe UI Symbol', sans-serif; font-size: 12pt;">&#9744;</div>
          </td>
          <td style="width: 90.93%; vertical-align: middle;">
            <div style="font-size: 12pt;">Rule 13d-1(c)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 4.48%; vertical-align: top;">&#160;</td>
          <td style="width: 4.59%; vertical-align: middle;">
            <div style="font-family: 'Wingdings 2', serif; font-size: 12pt;">&#9746;</div>
          </td>
          <td style="width: 90.93%; vertical-align: middle;">
            <div style="font-size: 12pt;">Rule 13d-1(d)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: justify;"><sup style="font-family: Symbol, serif; vertical-align: text-top; line-height: 1; font-size: smaller;">*</sup> The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form
      with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.</div>
    <div><br>
    </div>
    <div style="text-align: justify;">The information required in the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act
      of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">(Continued on following pages)</div>
    <div style="text-align: center; font-size: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman',Times,serif;">Page </font><font style="font-size: 10pt;">1<font style="font-family: 'Times New Roman',Times,serif;"> of </font>5 <font style="font-family: 'Times New Roman',Times,serif;">Pages</font></font></div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <!--PROfilePageNumberReset%Num%2%Page % of 5 Pages%-->
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">13G</div>
    <table cellspacing="0" cellpadding="0" id="z88770bca0b954736855c6c3144af4bcd" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 34.96%; vertical-align: top;">
            <div style="font-size: 12pt; font-weight: bold;">CUSIP No. G8128Y157</div>
          </td>
          <td style="width: 65.04%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="ze3ee685779e347378a15ef318f960826" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 8.45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-size: 18pt; font-weight: bold;">1</div>
          </td>
          <td style="width: 91.55%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="3">
            <div style="font-weight: bold;">NAMES OF REPORTING PERSONS</div>
            <div>&#160;</div>
            <div style="font-weight: bold;">Lombard Odier Asset Management (USA) Corp</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-size: 18pt; font-weight: bold;">2</div>
          </td>
          <td style="width: 91.55%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="3">
            <div style="font-weight: bold;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See
                Instructions)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
            <div style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(a)&#160;[&#160;&#160;]</div>
            <div style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(b)&#160;[&#160;&#160;]</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-size: 18pt; font-weight: bold;">3</div>
          </td>
          <td style="width: 91.55%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="3">
            <div style="font-weight: bold;">SEC USE ONLY</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-size: 18pt; font-weight: bold;">4</div>
          </td>
          <td style="width: 91.55%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="3">
            <div style="font-weight: bold;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div>&#160;</div>
            <div style="font-weight: bold;">Delaware</div>
          </td>
        </tr>
        <tr>
          <td style="width: 17.67%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" rowspan="4" colspan="2">
            <div style="text-align: center; font-weight: bold;">NUMBER OF</div>
            <div>&#160;</div>
            <div style="text-align: center; font-weight: bold;">SHARES BENEFICIALLY</div>
            <div style="text-align: center; font-weight: bold;">OWNED BY</div>
            <div>&#160;</div>
            <div style="text-align: center; font-weight: bold;">EACH</div>
            <div>&#160;</div>
            <div style="text-align: center; font-weight: bold;">REPORTING&#160; PERSON WITH</div>
          </td>
          <td style="width: 11.65%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-size: 18pt; font-weight: bold;">5</div>
          </td>
          <td style="width: 70.68%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="font-weight: bold;">SOLE VOTING POWER</div>
            <div>&#160;</div>
            <div style="font-weight: bold;">-0-</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.22%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-size: 18pt; font-weight: bold;">6</div>
          </td>
          <td style="width: 11.65%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="font-weight: bold;">SHARED VOTING POWER</div>
            <div>&#160;</div>
            <div style="font-weight: bold;">11,637,519 <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.22%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-size: 18pt; font-weight: bold;">7</div>
          </td>
          <td style="width: 11.65%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="font-weight: bold;">SOLE DISPOSITIVE POWER</div>
            <div>&#160;</div>
            <div style="font-weight: bold;">-0-</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.22%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-size: 18pt; font-weight: bold;">8</div>
          </td>
          <td style="width: 11.65%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="font-weight: bold;">SHARED DISPOSITIVE POWER</div>
            <div>&#160;</div>
            <div style="font-weight: bold;">11,637,519 <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-size: 18pt; font-weight: bold;">9</div>
          </td>
          <td style="width: 91.55%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="3">
            <div style="font-weight: bold;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div>&#160;</div>
            <div style="font-weight: bold;">11,637,519 <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-size: 18pt; font-weight: bold;">10</div>
          </td>
          <td style="width: 91.55%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="3">
            <div style="font-weight: bold;">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES</div>
            <div style="font-weight: bold;">CERTAIN SHARES (See Instructions)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
            <div style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;[&#160;&#160;&#160;&#160;&#160;]</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-size: 18pt; font-weight: bold;">11</div>
          </td>
          <td style="width: 91.55%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="3">
            <div style="font-weight: bold;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</div>
            <div>&#160;</div>
            <div style="font-weight: bold;">10.4% <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.45%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0); border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-size: 18pt; font-weight: bold;">12</div>
          </td>
          <td style="width: 91.55%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);" colspan="3">
            <div style="font-weight: bold;">TYPE OF REPORTING PERSON (See Instructions)</div>
            <div>&#160;</div>
            <div style="font-weight: bold;">&#160;IA; OO</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1 </sup>Includes 11,637,519 Shares represented by ADSs (as defined in the Preliminary Note).</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">Page 2 of 5 Pages</font></div>
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-size: 12pt;"> <br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-size: 12pt;">This Amendment No. 3 to Schedule 13G amends and restates in its entirety the Schedule 13G initially filed on February 16, 2021 (together
      with all prior and current amendments thereto, this &#8220;<u>Schedule 13G</u>&#8221;).</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><u>Preliminary Note</u>:</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-size: 12pt;">As of the date of this report, the Investment Advisor beneficially owns an aggregate of 11,637,519 Shares, consisting of 3,879,173
      American Depositary Shares (&#8220;<u>ADSs</u>&#8221;), each of which represents, and at the holder&#8217;s option is convertible into, three Shares. Capitalized terms used in this
      Preliminary Note without definition have the meanings set forth below.</div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 72pt; vertical-align: top;"><font style="font-size: 12pt;"><u>Item 1</u>.</font></td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-size: 12pt;"><u>Issuer</u></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
    </div>
    <div style="text-indent: 36pt;"><font style="font-size: 12pt;">(a)</font><font style="width: 9pt; font-size: 1px; display: inline-block;" class="HorizontalTab"> &#160;</font><font style="font-size: 12pt;"><u>Name of Issuer</u>:</font></div>
    <div><br>
    </div>
    <div style="text-indent: 72pt; font-size: 12pt;">Silence Therapeutics plc (the &#8220;<u>Company</u>&#8221;)</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;"><font style="font-size: 12pt;">(b)</font><font style="width: 9pt; font-size: 1px; display: inline-block;" class="HorizontalTab"> &#160;</font><font style="font-size: 12pt;"><u>Address of
            Issuer&#8217;s Principal Executive Offices</u>:</font></div>
    <div><br>
    </div>
    <div style="margin-left: 72pt; font-size: 12pt;">72 Hammersmith Road</div>
    <div style="margin-left: 72pt; font-size: 12pt;">London W14 8TH</div>
    <div style="margin-left: 72pt; font-size: 12pt;">United Kingdom</div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 72pt; vertical-align: top;"><font style="font-size: 12pt;"><u>Item 2</u>.</font></td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-size: 12pt;"><u>Identity and Background</u></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
    </div>
    <div style="text-indent: 36pt; font-size: 12pt;"><u>Title of Class of Securities and CUSIP Number (Items 2(d)
          and (e)</u>)</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-size: 12pt;">This statement relates to ordinary shares, par value &#163;0.05 per share (the &#8220;<u>Shares</u>&#8221;), of the Company. The CUSIP number of the Shares is G8128Y157.</div>
    <div><br>
    </div>
    <div style="text-align: justify; margin-left: 36pt; font-size: 12pt;"><u>Name of Persons Filing, Address of Principal Business Office and Citizenship (Items 2(a), (b) and (c))</u></div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-size: 12pt;">This statement is filed by Lombard Odier Asset Management (USA) Corp (the &#8220;<u>Investment Advisor</u>&#8221;), with respect to ADSs held by 1798 Volantis Fund Ltd, 1798 UK Small Cap Best Ideas Fund Ltd and one or more managed accounts. The Investment Advisor serves as the investment advisor to each of the
      foregoing.</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-size: 12pt;">The Investment Advisor is a corporation organized under the laws of the State of Delaware. The address of the principal business office
      of the Investment Advisor is 452 Fifth Avenue, 25<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> Floor, New York, NY 10018.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="zd0f52636c2304e9e80da55bb4b5238ca" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 72pt; vertical-align: top;"><font style="font-size: 12pt;"><u>Item 3</u>.</font></td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div style="font-size: 12pt;"><u>If This Statement Is Filed Pursuant to Sections 240.13d-1(b) or 240.13d-2(b) or (c),&#160; &#160;
                  &#160; &#160;&#160; Check Whether the Person Filing Is an Entity Specified in (a) - (k)</u>:</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="margin-left: 36pt; font-size: 12pt;">Not applicable.</div>
    <div style="margin-left: 36pt; font-size: 12pt;"> <br>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">Page 3 of 5 Pages</font></div>
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 72pt; vertical-align: top;"><font style="font-size: 12pt;"><u>Item 4</u>.</font></td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-size: 12pt;"><u>Ownership <br>
                  </u></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-size: 12pt;">The percentages used herein and in the rest of this Schedule 13G are calculated based upon 111,916,155 Shares issued and outstanding as
      of September 30, 2023, as disclosed in the Company&#8217;s Report of Foreign Private Issuer on Form 6-K filed with the Securities and Exchange Commission on November 14, 2023.</div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="zf74ab6059dd640e4b1e5c6e9b1d6228c" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt; vertical-align: top; text-align: right;">
              <div style="text-align: left; margin-left: 18pt; font-size: 12pt;">(a)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-size: 12pt;">Amount beneficially owned: 11,637,519 Shares</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="z95863d18dcc94b0a8167236032911898" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt; vertical-align: top; text-align: right;">
              <div style="text-align: left; margin-left: 18pt; font-size: 12pt;">(b)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-size: 12pt;">Percent of class: 10.4%</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="zfffdca920ee7441992157b6f0a16d107" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt; vertical-align: top; text-align: right;">
              <div style="text-align: left; margin-left: 18pt; font-size: 12pt;">(c)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-size: 12pt;">(i) Sole power to vote or direct the vote: 0</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="margin-left: 36pt; font-size: 12pt;">(ii) Shared power to vote or direct the vote: 11,637,519</div>
    <div style="margin-left: 36pt; font-size: 12pt;">(iii) Sole power to dispose or direct the disposition: 0</div>
    <div style="text-align: justify; text-indent: 36pt; font-size: 12pt;">(iv) Shared power to dispose or direct the disposition of: 11,637,519</div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 72pt; vertical-align: top;"><font style="font-size: 12pt;"><u>Item 5</u>.</font></td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-size: 12pt;"><u>Ownership of Five Percent or Less of a Class</u></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
    </div>
    <div style="text-indent: 36pt; font-size: 12pt;">If this statement is being filed to report the fact that as of the date hereof each of the Reporting Persons has ceased to be a
        beneficial owner of more than five percent of the class of securities, check the following:</div>
    <br>
    <div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 72pt; vertical-align: top;"><font style="font-size: 12pt;"><u>Item 6</u>.</font></td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-size: 12pt;"><u>Ownership of More than Five Percent on Behalf of Another Person</u></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
    </div>
    <div style="text-indent: 36pt; font-size: 12pt;">Not applicable.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z5643eae02e8645a5965acd9f05da10ff" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 72pt; vertical-align: top;"><font style="font-size: 12pt;"><u>Item 7</u>.</font></td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-size: 12pt;"><u>Identification and Classification of the Subsidiary Which Acquired the Security Being</u>&#160;<u>Reported on by the Parent Holding Company or Control Person</u></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="margin-left: 36pt; font-size: 12pt;">&#160;Not applicable.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z3393feada1244ef0b0f097186345b683" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 72pt; vertical-align: top;"><font style="font-size: 12pt;"><u>Item 8</u>.</font></td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-size: 12pt;"><u>Identification and Classification of Members of the Group</u></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-indent: 36pt; font-size: 12pt;">Not applicable.</div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 72pt; vertical-align: top;"><font style="font-size: 12pt;"><u>Item 9</u>.</font></td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-size: 12pt;"><u>Notice of Dissolution of Group</u></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
    </div>
    <div style="margin-left: 36pt; font-size: 12pt;">Not applicable.</div>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 72pt; vertical-align: top;"><font style="font-size: 12pt;"><u>Item 10</u>.</font></td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-size: 12pt;"><u>Certification</u></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
    </div>
    <div style="margin-left: 36pt; font-size: 12pt;">Not applicable.</div>
    <div style="margin-left: 36pt; font-size: 12pt;"> <br>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">Page 4 of 5 Pages</font></div>
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div><br>
    </div>
    <div style="text-align: center; font-size: 12pt;"><u>SIGNATURES</u></div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; font-size: 12pt;">After reasonable inquiry and to the best of my knowledge and belief, the undersigned certifies that the information set forth in this
      statement is true, complete and correct.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Dated:&#160; February 14, 2024</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Lombard Odier Asset Management (USA) Corp</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="za99fb6eb043449fdacd5982d7733d7a5" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 5.88%; vertical-align: top;">
            <div style="font-size: 12pt;">By:</div>
          </td>
          <td style="width: 38.48%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">/s/ Elyse Strauss</div>
          </td>
          <td style="width: 55.64%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 5.88%; vertical-align: top;">&#160;</td>
          <td style="width: 38.48%; vertical-align: top;">&#160;</td>
          <td style="width: 55.64%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 5.88%; vertical-align: top;">&#160;</td>
          <td style="width: 38.48%; vertical-align: top;">
            <div style="font-size: 12pt;">Name: Elyse Strauss</div>
          </td>
          <td style="width: 55.64%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 5.88%; vertical-align: top;">&#160;</td>
          <td style="width: 38.48%; vertical-align: top;">
            <div style="font-size: 12pt;">Title: Authorized Signatory</div>
          </td>
          <td style="width: 55.64%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <div><br>
    </div>
  </div>
  <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">Page 5 of 5 Pages</font></div>
</body>
</html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
