<SEC-DOCUMENT>0000908834-24-000337.txt : 20241114
<SEC-HEADER>0000908834-24-000337.hdr.sgml : 20241114
<ACCEPTANCE-DATETIME>20241114131314
ACCESSION NUMBER:		0000908834-24-000337
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20241114
DATE AS OF CHANGE:		20241114

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Silence Therapeutics plc
		CENTRAL INDEX KEY:			0001479615
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-92205
		FILM NUMBER:		241459758

	BUSINESS ADDRESS:	
		STREET 1:		72 HAMMERSMITH ROAD
		CITY:			LONDON
		STATE:			X0
		ZIP:			W14 8TH
		BUSINESS PHONE:		44-0-20-3457 6900

	MAIL ADDRESS:	
		STREET 1:		72 HAMMERSMITH ROAD
		CITY:			LONDON
		STATE:			X0
		ZIP:			W14 8TH

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Lombard Odier Asset Management (USA) Corp
		CENTRAL INDEX KEY:			0001491719
		ORGANIZATION NAME:           	
		IRS NUMBER:				061603711
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		452 FIFTH AVENUE, 25TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10018
		BUSINESS PHONE:		212-295-6200

	MAIL ADDRESS:	
		STREET 1:		452 FIFTH AVENUE, 25TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10018
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>silence_13ga.htm
<TEXT>
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    <div style="text-align: center; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-weight: bold;">Washington, DC&#160; 20549</div>
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    <div style="text-align: center; font-size: 14pt; font-weight: bold;">SCHEDULE 13G</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Under the Securities Exchange Act of 1934</div>
    <div style="text-align: center; font-weight: bold;">(Amendment No. 4)&#160;&#160;&#160;<sup style="font-family: Symbol, serif; vertical-align: text-top; line-height: 1; font-size: smaller;">*</sup></div>
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            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">Silence Therapeutics plc</div>
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          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; font-size: 8pt;">(Name of Issuer)</div>
            <div>&#160;</div>
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            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">Ordinary Shares, par value &#163;0.05 per share</div>
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            <div style="text-align: center; font-size: 8pt;">(Title of Class of Securities)</div>
            <div>&#160;</div>
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            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">G8128Y157</div>
          </td>
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          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; font-size: 8pt;">(Cusip Number)</div>
            <div>&#160;</div>
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            <div style="text-align: center; font-family: 'Times New Roman',Times,serif;">September 30, 2024</div>
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            <div style="text-align: center; font-size: 8pt;">(Date of Event which Requires Filing of this Statement)</div>
            <div>&#160;</div>
          </td>
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    <div>Check the appropriate box to designate the rule pursuant to which this Schedule is filed:</div>
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          <td style="width: 4.48%; vertical-align: top; font-size: 11pt;">&#160;</td>
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            <div style="font-family: 'Segoe UI Symbol',sans-serif; font-size: 11pt;">&#9744;</div>
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            <div style="font-family: 'Times New Roman',Times,serif; font-size: 11pt;">Rule 13d-1(b)</div>
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            <div style="font-family: 'Segoe UI Symbol',sans-serif; font-size: 11pt;">&#9744;</div>
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            <div style="font-family: 'Times New Roman',Times,serif; font-size: 11pt;">Rule 13d-1(c)</div>
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            <div style="font-family: 'Wingdings 2',serif; font-size: 11pt;">&#9746;</div>
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            <div style="font-family: 'Times New Roman',Times,serif; font-size: 11pt;">Rule 13d-1(d)</div>
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    <div><br>
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    <div style="text-align: justify;"><sup style="font-family: Symbol, serif; vertical-align: text-top; line-height: 1; font-size: smaller;">*</sup> The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any
      subsequent amendment containing information which would alter the disclosures provided in a prior cover page.</div>
    <div><br>
    </div>
    <div style="text-align: justify;">The information required in the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of
      that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
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    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">(Continued on following pages)</div>
    <div style="text-align: center; font-size: 12pt;"><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;">Page </font><font style="font-size: 11pt;">1<font style="font-family: 'Times New Roman',Times,serif;"> of </font>5 <font style="font-family: 'Times New Roman',Times,serif;">Pages</font></font></div>
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    <div style="text-align: center; font-size: 14pt; font-weight: bold;">13G</div>
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            <div style="font-size: 12pt; font-weight: bold;">CUSIP No. G8128Y157</div>
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          <td style="width: 65.04%; vertical-align: top;">&#160;</td>
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            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 18pt; font-weight: bold;">1</div>
          </td>
          <td colspan="3" style="width: 91.55%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-right: 1px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">NAMES OF REPORTING PERSONS</div>
            <div>&#160;</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Lombard Odier Asset Management (USA) Corp</div>
          </td>
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          <td style="width: 8.45%; vertical-align: middle; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 18pt; font-weight: bold;">2</div>
          </td>
          <td colspan="3" style="width: 91.55%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-right: 1px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(a)&#160;[&#160;&#160;]</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(b)&#160;[&#160;&#160;]</div>
            <div>&#160;</div>
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            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 18pt; font-weight: bold;">3</div>
          </td>
          <td colspan="3" style="width: 91.55%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-right: 1px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">SEC USE ONLY</div>
            <div>&#160;</div>
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          <td style="width: 8.45%; vertical-align: middle; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 18pt; font-weight: bold;">4</div>
          </td>
          <td colspan="3" style="width: 91.55%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-right: 1px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div>&#160;</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">Delaware</div>
          </td>
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          <td colspan="2" rowspan="4" style="width: 17.67%; vertical-align: middle; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">NUMBER OF</div>
            <div>&#160;</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">SHARES BENEFICIALLY</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">OWNED BY</div>
            <div>&#160;</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">EACH</div>
            <div>&#160;</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">REPORTING&#160; PERSON WITH</div>
          </td>
          <td style="width: 11.65%; vertical-align: middle; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 18pt; font-weight: bold;">5</div>
          </td>
          <td style="width: 70.68%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-right: 1px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">SOLE VOTING POWER</div>
            <div>&#160;</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">-0-</div>
          </td>
        </tr>
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          <td style="width: 9.22%; vertical-align: middle; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 18pt; font-weight: bold;">6</div>
          </td>
          <td style="width: 11.65%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-right: 1px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">SHARED VOTING POWER</div>
            <div>&#160;</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">7,992,231 <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.22%; vertical-align: middle; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 18pt; font-weight: bold;">7</div>
          </td>
          <td style="width: 11.65%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-right: 1px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">SOLE DISPOSITIVE POWER</div>
            <div>&#160;</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">-0-</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.22%; vertical-align: middle; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 18pt; font-weight: bold;">8</div>
          </td>
          <td style="width: 11.65%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-right: 1px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">SHARED DISPOSITIVE POWER</div>
            <div>&#160;</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">7,992,231 <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.45%; vertical-align: middle; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 18pt; font-weight: bold;">9</div>
          </td>
          <td colspan="3" style="width: 91.55%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-right: 1px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div>&#160;</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">7,992,231 <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.45%; vertical-align: middle; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 18pt; font-weight: bold;">10</div>
          </td>
          <td colspan="3" style="width: 91.55%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-right: 1px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">CERTAIN SHARES (See Instructions)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;[&#160;&#160;&#160;&#160;&#160;]</div>
            <div>&#160;</div>
          </td>
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          <td style="width: 8.45%; vertical-align: middle; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 18pt; font-weight: bold;">11</div>
          </td>
          <td colspan="3" style="width: 91.55%; vertical-align: top; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-right: 1px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</div>
            <div>&#160;</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">5.7% <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.45%; vertical-align: middle; border-top: 1px solid rgb(0, 0, 0); border-left: 1px solid rgb(0, 0, 0); border-bottom: 1px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 18pt; font-weight: bold;">12</div>
          </td>
          <td colspan="3" style="width: 91.55%; vertical-align: top; border-width: 1px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">TYPE OF REPORTING PERSON (See Instructions)</div>
            <div>&#160;</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">&#160;IA; OO</div>
          </td>
        </tr>

    </table>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 11pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1 </sup>Includes 7,992,231 Shares represented by ADSs (as defined in the Preliminary Note).</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;"> <br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">This Amendment No. 4 to Schedule 13G amends and restates in its entirety the Schedule 13G initially filed on February 16, 2021 (together
      with all prior and current amendments thereto, this &#8220;<u>Schedule 13G</u>&#8221;).</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Preliminary Note</u></font><font style="font-size: 11pt;">:</font></div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">As of the date of this report, the Investment Advisor beneficially owns an aggregate of&#160; 7,992,231 Shares, consisting of 2,664,077
      American Depositary Shares (&#8220;<u>ADSs</u>&#8221;), each of which represents, and at the holder&#8217;s option is convertible into, three Shares. Capitalized terms used in this Preliminary Note without definition have the meanings set forth below.</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-align: justify;"><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Item 1</u>.</font>&#160; <font style="font-family: 'Times New Roman',Times,serif; font-size: 11pt;"><u>Issuer</u></font></div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-indent: 36pt;"><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;">(a)</font>&#160; <font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Name of Issuer</u>:</font></div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-indent: 72pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">Silence Therapeutics plc (the &#8220;<u>Company</u>&#8221;)</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-indent: 36pt;"><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;">(b)</font>&#160; <font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Address of Issuer&#8217;s Principal Executive Offices</u>:</font></div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="margin-left: 72pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">72 Hammersmith Road</div>
    <div style="margin-left: 72pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">London W14 8TH</div>
    <div style="margin-left: 72pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">United Kingdom</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Item 2</u>.</font>&#160; <font style="font-family: 'Times New Roman',Times,serif; font-size: 11pt;"><u>Identity and Background</u></font></div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-indent: 36pt; font-size: 12pt;"><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Title of Class of Securities and CUSIP Number (Items 2(d) and (e)</u></font><font style="font-size: 11pt;">)</font></div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">This statement relates to ordinary shares, par value &#163;0.05 per share (the &#8220;<u>Shares</u>&#8221;), of the Company. The CUSIP number of the Shares
      is G8128Y157.</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-align: justify; margin-left: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;"><u>Name of Persons Filing, Address of Principal Business Office and Citizenship (Items 2(a), (b) and (c))</u></div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">This statement is filed by Lombard Odier Asset Management (USA) Corp (the &#8220;<u>Investment Advisor</u>&#8221;), with respect to ADSs held by 1798
      Volantis Fund Ltd, 1798 UK Small Cap Best Ideas Fund Ltd and one or more managed accounts. The Investment Advisor serves as the investment advisor to each of the foregoing.</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">The Investment Advisor is a corporation organized under the laws of the State of Delaware. The address of the principal business office of
      the Investment Advisor is 452 Fifth Avenue, 25<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> Floor, New York, NY 10018.</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="ze96e0dd926534a968083dd4b06cf2fbf">

        <tr>
          <td style="width: 72pt; vertical-align: top;"><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Item 3</u>.</font></td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div style="font-size: 12pt;"><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>If This Statement Is Filed Pursuant to Sections 240.13d-1(b) or 240.13d-2(b) or (c),&#160; &#160; &#160; &#160;&#160; Check Whether the Person Filing Is an
                  Entity Specified in (a) - (k)</u></font><font style="font-size: 11pt;">:</font></div>
          </td>
        </tr>

    </table>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="margin-left: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">Not applicable.</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Item 4</u>.</font>&#160; <font style="font-family: 'Times New Roman',Times,serif; font-size: 11pt;"><u>Ownership</u></font></div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">The percentages used herein and in the rest of this Schedule 13G are calculated based upon 139,979,812 Shares issued and outstanding as of
      April 15, 2024, as disclosed in the Company&#8217;s prospectus filed with the Securities and Exchange Commission pursuant to Rule 424(b)(3) on May 14, 2024.</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z47af4dedc04c49e8851c1267d911c455">

          <tr>
            <td style="width: 36pt; vertical-align: top; text-align: right; font-size: 11pt;">
              <div style="text-align: left; margin-left: 18pt; font-family: 'Times New Roman',Times,serif;">(a)</div>
            </td>
            <td style="width: auto; vertical-align: top; font-size: 11pt;">
              <div style="text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">Amount beneficially owned: 7,992,231 Shares</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z66ca0adfe987416fbde9e91554ff7b7e">

          <tr>
            <td style="width: 36pt; vertical-align: top; text-align: right; font-size: 11pt;">
              <div style="text-align: left; margin-left: 18pt; font-family: 'Times New Roman',Times,serif;">(b)</div>
            </td>
            <td style="width: auto; vertical-align: top; font-size: 11pt;">
              <div style="text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">Percent of class: 5.7%</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2be91c54695a41d2a520c918042a9959">

          <tr>
            <td style="width: 36pt; vertical-align: top; text-align: right; font-size: 11pt;">
              <div style="text-align: left; margin-left: 18pt; font-family: 'Times New Roman',Times,serif;">(c)</div>
            </td>
            <td style="width: auto; vertical-align: top; font-size: 11pt;">
              <div style="text-indent: 36pt; font-family: 'Times New Roman',Times,serif;">(i) Sole power to vote or direct the vote: 0</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="margin-left: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;"><font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;">&#160;&#160;&#160;&#160;</font>(ii) Shared power to vote or direct the vote: 7,992,231</div>
    <div style="margin-left: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;"><font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;">&#160;&#160;&#160;&#160;</font>(iii) Sole power to dispose or direct the disposition: 0</div>
    <div style="text-align: justify; text-indent: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;"><font class="HorizontalTab" style="width: 9pt; font-size: 1px; display: inline-block;">&#160;&#160;&#160;&#160;</font>(iv) Shared power to dispose or direct
      the disposition of: 7,992,231</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Item 5</u>.</font>&#160; <font style="font-family: 'Times New Roman',Times,serif; font-size: 11pt;"><u>Ownership of Five Percent or Less of a Class</u></font></div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-indent: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">If this statement is being filed to report the fact that as of the date hereof each of the Reporting Persons has ceased to be a beneficial owner of more than
      five percent of the class of securities, check the following:</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Item 6</u>.</font>&#160; <font style="font-family: 'Times New Roman',Times,serif; font-size: 11pt;"><u>Ownership of More than Five Percent on Behalf of Another Person</u></font></div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-indent: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">Not applicable.</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z19c8f6714102447ca3bfd41154c30976">

        <tr>
          <td style="width: 72pt; vertical-align: top;"><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Item 7</u>.</font></td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-size: 12pt;"><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Identification and Classification of the Subsidiary Which Acquired the Security Being</u></font><font style="font-size: 11pt;">&#160;<font style="font-family: 'Times New Roman',Times,serif;"><u>Reported on by the Parent Holding Company or Control Person</u></font></font></div>
          </td>
        </tr>

    </table>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="margin-left: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">&#160;Not applicable.</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zd23578b5ae32452c8eb4925c68d0b82f">

        <tr>
          <td style="width: 72pt; vertical-align: top;"><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Item 8</u>.</font></td>
          <td style="width: auto; vertical-align: top; font-size: 11pt;">
            <div style="font-family: 'Times New Roman',Times,serif;"><u>Identification and Classification of Members of the Group</u></div>
          </td>
        </tr>

    </table>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-indent: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">Not applicable.</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Item 9</u>.</font>&#160; <font style="font-family: 'Times New Roman',Times,serif; font-size: 11pt;"><u>Notice of Dissolution of Group</u></font></div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="margin-left: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">Not applicable.</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-size: 11pt; font-family: 'Times New Roman',Times,serif;"><u>Item 10</u></font><font style="font-size: 11pt;">.&#160; <font style="font-family: 'Times New Roman',Times,serif;"><u>Certification</u></font></font></div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="margin-left: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">Not applicable.</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
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    </div>
    <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 11pt;"><u>SIGNATURES</u></div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="text-indent: 36pt; font-family: 'Times New Roman',Times,serif; font-size: 11pt;">After reasonable inquiry and to the best of my knowledge and belief, the undersigned certifies that the information set forth in this statement is true,
      complete and correct.</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 11pt;">Dated:&#160; November 14, 2024</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 11pt;">Lombard Odier Asset Management (USA) Corp</div>
    <div style="font-size: 11pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z05ddbb19017b445ca6c4519e62f95b87">

        <tr>
          <td style="width: 5.88%; vertical-align: top; font-size: 11pt; padding-bottom: 2px;">
            <div style="font-family: 'Times New Roman',Times,serif;">By:</div>
          </td>
          <td style="width: 38.48%; vertical-align: top; font-size: 11pt; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman',Times,serif;">/s/ Elyse Strauss</div>
          </td>
          <td style="width: 55.64%; vertical-align: top; font-size: 11pt; padding-bottom: 2px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 5.88%; vertical-align: top; font-size: 11pt;">&#160;</td>
          <td style="width: 38.48%; vertical-align: top; font-size: 11pt;">&#160;</td>
          <td style="width: 55.64%; vertical-align: top; font-size: 11pt;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 5.88%; vertical-align: top; font-size: 11pt;">&#160;</td>
          <td style="width: 38.48%; vertical-align: top; font-size: 11pt;">
            <div style="font-family: 'Times New Roman',Times,serif;">Name: Elyse Strauss</div>
          </td>
          <td style="width: 55.64%; vertical-align: top; font-size: 11pt;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 5.88%; vertical-align: top; font-size: 11pt;">&#160;</td>
          <td style="width: 38.48%; vertical-align: top; font-size: 11pt;">
            <div style="font-family: 'Times New Roman',Times,serif;">Title: Authorized Signatory</div>
          </td>
          <td style="width: 55.64%; vertical-align: top; font-size: 11pt;">&#160;</td>
        </tr>

    </table>
    <div style="font-size: 11pt;"><br>
    </div>
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