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Revenue (Tables) | 12 Months Ended
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Dec. 31, 2024
Revenues [Abstract] |
Summary of Disaggregation of Revenue from Contracts with Customers | Disaggregation of revenue from contracts with customers is as follows:
|  | Year ended December 31, |
|  | 2024 |  |  | 2023 |  |  | 2022 |
|  | $000s |  |  | $000s |  |  | $000s |
Revenue from Contracts with Customers |  |  |  |  |  |  |  |  |
Research collaboration - Mallinckrodt plc |  |  | 584 |  |  |  | 13,149 |  |  |  | 14,425 |
Research collaboration - AstraZeneca |  |  | 17,957 |  |  |  | 17,062 |  |  |  | 6,287 |
Research collaboration - Hansoh |  |  | 24,573 |  |  |  | 722 |  |  |  | 228 |
Research collaboration - total |  |  | 43,114 |  |  |  | 30,933 |  |  |  | 20,940 |
Royalties |  |  | 144 |  |  |  | 710 |  |  |  | 715 |
Total revenue from contracts with customers |  |  | 43,258 |  |  |  | 31,643 |  |  |  | 21,655 |

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- Definition Tabular disclosure of disaggregation of revenue into categories depicting how nature, amount, timing, and uncertainty of revenue and cash flows are affected by economic factor. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 606 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 5 -Publisher FASB -URI https://asc.fasb.org/1943274/2147479806/606-10-50-5 + Details
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