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Summary of Significant Accounting Policies - Additional Information (Details)
 12 Months Ended
Feb. 05, 2024
USD ($)
OrdinaryShare
$ / shares
shares
Dec. 31, 2024
USD ($)
Segment
Dec. 31, 2023
USD ($)
shares
Dec. 31, 2022
USD ($)
Summary Of Significant Accounting Policies [Line Items]        
Net loss   $ (45,309,000) $ (54,228,000) $ (50,334,000)
Accumulated losses   474,044,000 431,894,000  
Cash outflows from operating activities   (67,640,000) (49,462,000) (57,044,000)
Cash and cash equivalents and short-term investments   $ 147,300,000    
Number of reportable segments | Segment   1    
Goodwill impairment loss   $ 0 0  
Change in accounting principle, accounting standards update, adopted [true false]   true    
Accounting standards update [extensible enumeration]   us-gaap:AccountingStandardsUpdate202307Member    
American Depositary Shares        
Summary Of Significant Accounting Policies [Line Items]        
Gross proceeds from private placement $ 120,000,000      
Open Market Sale Agreement | American Depositary Shares | Jefferies LLC        
Summary Of Significant Accounting Policies [Line Items]        
Gross proceeds from sale of stock   $ 27,700,000    
Placement agent fees and other expenses   900,000 $ 1,000,000  
Sale of stock, number of shares issued | shares     3,400,000  
Gross proceeds from private placement   27,700,000    
Private Placement | American Depositary Shares        
Summary Of Significant Accounting Policies [Line Items]        
Placement agent fees and other expenses $ 7,700,000      
Sale of stock, number of shares issued | shares 5,714,286      
Number of ordinary shares in American Depositary Share | OrdinaryShare 3      
Sale of stock, price per share | $ / shares $ 21      
Gross proceeds from private placement $ 120,000,000      
Collaboration Agreement with AstraZeneca        
Summary Of Significant Accounting Policies [Line Items]        
Milestone payments received   10,000,000 $ 10,000,000  
Collaboration Agreement with Hansoh        
Summary Of Significant Accounting Policies [Line Items]        
Milestone payments received   $ 2,000,000 $ 4,000,000 $ 1,500,000
Minimum | Licenses and Software        
Summary Of Significant Accounting Policies [Line Items]        
Estimated useful lives of intangible assets   3 years    
Minimum | Furniture and Equipment        
Summary Of Significant Accounting Policies [Line Items]        
Estimated useful life of property, plant and equipment   3 years    
Maximum        
Summary Of Significant Accounting Policies [Line Items]        
Invoice raise duration after quarter end   75 days    
Maximum | Licenses and Software        
Summary Of Significant Accounting Policies [Line Items]        
Estimated useful lives of intangible assets   10 years    
Maximum | Furniture and Equipment        
Summary Of Significant Accounting Policies [Line Items]        
Estimated useful life of property, plant and equipment   10 years