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Summary of Significant Accounting Policies - Additional Information (Details)
 3 Months Ended 9 Months Ended 12 Months Ended
Feb. 05, 2024
USD ($)
OrdinaryShare
$ / shares
shares
Sep. 30, 2025
USD ($)
Jun. 30, 2025
USD ($)
Mar. 31, 2025
USD ($)
Sep. 30, 2024
USD ($)
Jun. 30, 2024
USD ($)
Mar. 31, 2024
USD ($)
Sep. 30, 2025
USD ($)
Sep. 30, 2024
USD ($)
Dec. 31, 2024
USD ($)
Summary Of Significant Accounting Policies [Line Items]                    
Net loss   $ 20,958,000 $ 27,354,000 $ 28,530,000 $ 35,544,000 $ 19,755,000 $ 2,312,000 $ 76,842,000 $ 57,611,000  
Accumulated losses   550,802,000           550,802,000   $ 474,044,000
Cash outflows from operating activities               44,984,000 40,159,000  
Cash and cash equivalents and short-term investments   $ 102,200,000           102,200,000    
American Depositary Shares                    
Summary Of Significant Accounting Policies [Line Items]                    
Gross proceeds from private placement $ 120,000,000                  
Open Market Sale Agreement | American Depositary Shares | Jefferies LLC                    
Summary Of Significant Accounting Policies [Line Items]                    
Gross proceeds from sale of stock                   27,700,000
Placement agent fees and other expenses                   900,000
Private Placement | American Depositary Shares                    
Summary Of Significant Accounting Policies [Line Items]                    
Placement agent fees and other expenses $ 7,700,000                  
Sale of stock, number of shares issued | shares 5,714,286                  
Number of ordinary shares in American Depositary Share | OrdinaryShare 3                  
Sale of stock, price per share | $ / shares $ 21                  
Gross proceeds from private placement $ 120,000,000                  
Collaboration Agreement with AstraZeneca                    
Summary Of Significant Accounting Policies [Line Items]                    
Milestone payments received               $ 0 $ 10,000,000 10,000,000
Collaboration Agreement with Hansoh                    
Summary Of Significant Accounting Policies [Line Items]                    
Milestone payments received                   $ 2,000,000