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Revenue - Additional Information (Details) - USD ($)	3 Months Ended		9 Months Ended		12 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2025	Sep. 30, 2024	Dec. 31, 2024	Dec. 31, 2023	May 31, 2021	Dec. 31, 2020
Disaggregation of Revenue [Line Items]
Revenue	$ 159,000	$ 1,498,000	$ 525,000	$ 17,953,000
Upfront cash payment received	55,552,000		55,552,000		$ 52,096,000	$ 81,572,000
Collaboration Agreement with AstraZeneca
Disaggregation of Revenue [Line Items]
Revenue			500,000	16,300,000
Upfront cash payment received							$ 40,000,000	$ 20,000,000
Milestone payments received			0	10,000,000	$ 10,000,000
Research Collaboration Income
Disaggregation of Revenue [Line Items]
Revenue	159,000	1,496,000	525,000	17,808,000
Royalty Income
Disaggregation of Revenue [Line Items]
Revenue	$ 0	$ 2,000	$ 0	$ 145,000

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