<SEC-DOCUMENT>0001104659-25-068309-index.html : 20250716
<SEC-HEADER>0001104659-25-068309.hdr.sgml : 20250716
<ACCEPTANCE-DATETIME>20250716145836
ACCESSION NUMBER:		0001104659-25-068309
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20250711
FILED AS OF DATE:		20250716
DATE AS OF CHANGE:		20250716

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Griffiths Richard Ian
		CENTRAL INDEX KEY:			0001846370
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39487
		FILM NUMBER:		251127167

	MAIL ADDRESS:	
		STREET 1:		C/O SILENCE THERAPEUTICS INC.
		STREET 2:		72 HAMMERSMITH ROAD
		CITY:			LONDON
		STATE:			X0
		ZIP:			W14 8TH

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Silence Therapeutics plc
		CENTRAL INDEX KEY:			0001479615
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			X0

	BUSINESS ADDRESS:	
		STREET 1:		72 HAMMERSMITH ROAD
		CITY:			LONDON
		STATE:			X0
		ZIP:			W14 8TH
		BUSINESS PHONE:		44-0-20-3457 6900

	MAIL ADDRESS:	
		STREET 1:		72 HAMMERSMITH ROAD
		CITY:			LONDON
		STATE:			X0
		ZIP:			W14 8TH
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>tm2521080-1_4seq1.xml
<DESCRIPTION>OWNERSHIP DOCUMENT
<TEXT>
Document 1 - file: tm2521080-1_4seq1.html

Document 1 - RAW XML: tm2521080-1_4seq1.xml

</DOCUMENT>
</SEC-DOCUMENT>