<SEC-DOCUMENT>0002048873-25-000004-index.html : 20251222
<SEC-HEADER>0002048873-25-000004.hdr.sgml : 20251222
<ACCEPTANCE-DATETIME>20251222180231
ACCESSION NUMBER:		0002048873-25-000004
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20251214
FILED AS OF DATE:		20251222
DATE AS OF CHANGE:		20251222

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Ede-Golightly James
		CENTRAL INDEX KEY:			0002048873
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39487
		FILM NUMBER:		251593698

	MAIL ADDRESS:	
		STREET 1:		C/O SILENCE THERAPEUTICS PLC
		STREET 2:		72 HAMMERSMITH ROAD
		CITY:			LONDON
		STATE:			X0
		ZIP:			W14 8TH

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Silence Therapeutics plc
		CENTRAL INDEX KEY:			0001479615
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			X0

	BUSINESS ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		12 HAMMERSMITH GROVE
		STREET 2:		OFFICE 205
		CITY:			LONDON
		PROVINCE COUNTRY:   	X0
		ZIP:			W6 7AP
		BUSINESS PHONE:		44-0-20-3457 6900

	MAIL ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		12 HAMMERSMITH GROVE
		STREET 2:		OFFICE 205
		CITY:			LONDON
		PROVINCE COUNTRY:   	X0
		ZIP:			W6 7AP
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form3-12222025_111228.xml
<TEXT>
Document 1 - file: form3-12222025_111228.html

Document 1 - RAW XML: form3-12222025_111228.xml

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>ex24-12222025_111230.htm
<TEXT>
Document 2 - file: ex24-12222025_111230.htm

</DOCUMENT>
</SEC-DOCUMENT>