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Summary of Significant Accounting Policies - Additional Information (Details)
 3 Months Ended 12 Months Ended
Feb. 05, 2024
USD ($)
OrdinaryShare
$ / shares
shares
Mar. 31, 2026
USD ($)
Mar. 31, 2025
USD ($)
Dec. 31, 2024
USD ($)
Dec. 31, 2025
USD ($)
Summary Of Significant Accounting Policies [Line Items]          
Net loss   $ 14,957,000 $ 28,530,000    
Accumulated losses   577,526,000     $ 562,572,000
Cash outflows from operating activities   15,603,000 12,309,000    
Cash and cash equivalents and short-term investments   70,100,000      
American Depositary Shares          
Summary Of Significant Accounting Policies [Line Items]          
Gross proceeds from private placement $ 120,000,000        
Open Market Sale Agreement | American Depositary Shares | Jefferies LLC          
Summary Of Significant Accounting Policies [Line Items]          
Gross proceeds from sale of stock       $ 27,700,000  
Placement agent fees and other expenses       900,000  
Private Placement | American Depositary Shares          
Summary Of Significant Accounting Policies [Line Items]          
Placement agent fees and other expenses $ 7,700,000        
Sale of stock, number of shares issued | shares 5,714,286        
Number of ordinary shares in American Depositary Share | OrdinaryShare 3        
Sale of stock, price per share | $ / shares $ 21        
Collaboration Agreement with AstraZeneca          
Summary Of Significant Accounting Policies [Line Items]          
Milestone payments received   $ 0 $ 0 10,000,000  
Collaboration Agreement with Hansoh          
Summary Of Significant Accounting Policies [Line Items]          
Milestone payments received       $ 2,000,000