-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0000818033-10-000022.txt : 20100219
<SEC-HEADER>0000818033-10-000022.hdr.sgml : 20100219
<ACCEPTANCE-DATETIME>20100219135757
ACCESSION NUMBER:		0000818033-10-000022
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20100217
FILED AS OF DATE:		20100219
DATE AS OF CHANGE:		20100219

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AP PHARMA INC /DE/
		CENTRAL INDEX KEY:			0000818033
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				942875566
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		123 SAGINAW DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063
		BUSINESS PHONE:		6503662626

	MAIL ADDRESS:	
		STREET 1:		123 SAGINAW DRIVE
		STREET 2:		123 SAGINAW DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADVANCED POLYMER SYSTEMS INC /DE/
		DATE OF NAME CHANGE:	19920703

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			DAVIS STEPHEN
		CENTRAL INDEX KEY:			0001131146

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-33221
		FILM NUMBER:		10619089

	MAIL ADDRESS:	
		STREET 1:		NEUROGEN CORP
		STREET 2:		35 NORTHEAST INDUSTRIAL RD
		CITY:			BRANFORD
		STATE:			CT
		ZIP:			06405
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>edgardoc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2010-02-17</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000818033</issuerCik>
        <issuerName>AP PHARMA INC /DE/</issuerName>
        <issuerTradingSymbol>APPA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001131146</rptOwnerCik>
            <rptOwnerName>DAVIS STEPHEN</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>A.P. PHARMA, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>123 SAGINAW DRIVE</rptOwnerStreet2>
            <rptOwnerCity>REDWOOD CITY</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94063</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <ownerSignature>
        <signatureName>By: Natalie Godfrey - attorney-in-fact  For: Stephen R. Davis</signatureName>
        <signatureDate>2010-02-19</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>appadavis021910.txt
<DESCRIPTION>EDGAR SUPPORTING DOCUMENT
<TEXT>
                     POWER OF ATTORNEY

Know all by these present, that the undersigned hereby
constitutes and appoints Ronald J. Prentki, John B. Whelan,
Natalie Godfrey and those individuals appointed to the position
of Chief Executive Officer, President or Chief Financial Officer
of A.P. Pharma, Inc., the undersigned's true and lawful
attorney-in-fact to:

(1) execute for and on behalf of the undersigned, in the
    undersigned's capacity as an officer and/or director of A.P.
    Pharma, Inc., Forms 3, 4, and 5 in accordance with Section
    16(a) of the Securities Exchange Act of 1934 and the rules
    thereunder;

(2) do and perform any and all acts for and on behalf of the
    undersigned which may be necessary or desirable to complete
    and execute any such Form 3, 4, 5, complete and execute any
    amendment or amendments thereto, and timely file such form
    with the United States Securities and Exchange Commission
    and any stock exchange or similar authority; and

(3) take any other action of any type whatsoever in connection
    with the foregoing which, in the opinion of such attorney-
    in-fact, may be of benefit to, in the best interest of, or
    legally required by, the undersigned, it being understood
    that the documents executed by such attorney-in-fact on
    behalf of the undersigned pursuant to this Power of Attorney
    shall be in such form and shall contain such terms and
    conditions as such attorney-in-fact may approve in such
    attorney-in-fact's discretion.

The undersigned hereby grants to each such attorney-in-fact full
power and authority to do and perform any and every act and
thing whatsoever requisite, necessary, or proper to be done in
the exercise of any of the rights and powers herein granted, as
fully to all intents and purposes as the undersigned might or
could do if personally present, with full power of substitution
or revocation, hereby ratifying and confirming all that such
attorney-in-fact, or such attorney-in-fact's substitute or
substitutes, shall lawfully do or cause to be done by virtue of
this power of attorney and the rights and powers herein granted.
The undersigned acknowledges that the foregoing attorneys-in-
fact, in serving in such capacity at the request of the
undersigned, are not assuming, nor is the Company assuming, any
of the undersigned's responsibilities to comply with Section 16
of the Securities Exchange Act of 1934.

This Power of Attorney shall remain in full force and effect
until the undersigned is no longer required to file Forms 3, 4
and 5 with respect to the undersigned's holdings of and
transactions in securities issued by the Company, unless earlier
revoked by the undersigned in a signed writing delivered to the
foregoing attorneys-in-fact.

IN WITNESS WHEREOF, the undersigned has caused this Power of
Attorney to be executed as of this 17th day of February,2010.

                            /S/ Stephen R. Davis
                            ----------------------
                              Signature

                             Stephen R. Davis
                             ------------------
                             Printed Name
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----
