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NOTE 8 STOCKHOLDERS' EQUITY (Tables) | 12 Months Ended
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Dec. 31, 2012
Equity [Abstract] |
Stock option valuation assumptions |
|  | 2012 |  | 2011 |  | 2010
Expected term (years): |  |  |  |  |  |  |  |  |  |  |  |
Stock options |  |  | 5.51 |  |  |  | 5.00 |  |  |  | 6.00 |
Employee Stock Purchase Plan |  |  | .49 |  |  |  | .50 |  |  |  | .50 |
Risk-free interest rate: |  |  |  |  |  |  |  |  |  |  |  |
Stock options |  |  | 0.8 | % |  |  | 1.6 | % |  |  | 2.6 | %
Employee Stock Purchase Plan |  |  | 0.2 | % |  |  | 0.8 | % |  |  | 0.2 | %
Volatility: |  |  |  |  |  |  |  |  |  |  |  |
Stock options |  |  | 106 | % |  |  | 106 | % |  |  | 164 | %
Employee Stock Purchase Plan |  |  | 0.8 | % |  |  | 142 | % |  |  | 92 | %
Stock-based compensation expense (in thousands, except per share amounts) |
For the Years Ended December 31, |  | 2012 |  | 2011 |  | 2010
Research and development |  | $ | 1,585 |  |  | $ | 819 |  |  | $ | 398 |
General and administrative |  |  | 4,147 |  |  |  | 1,071 |  |  |  | 1,351 |
Total |  | $ | 5,732 |  |  | $ | 1,890 |  |  | $ | 1,749 |
Impact on basic and diluted net loss per common share |  | $ | 0.02 |  |  | $ | 0.02 |  |  | $ | 0.04 |
Stock option activity |
|  | 2012 |  | 2011 |  | 2010
|  |  |  |  |  | Weighted- |  | Aggregate |  |  |  |  |  |  |  |
|  |  |  | Weighted- |  | Average |  | Intrinsic |  |  |  | Weighted- |  |  |  | Weighted-
|  |  |  | Average |  | Remaining |  | Value as of |  |  |  | Average |  |  |  | Average
|  |  |  | Exercise |  | Contractual |  | December 31, |  |  |  | Exercise |  |  |  | Exercise
|  | Shares |  | Price |  | Term (Years) |  | 2012 |  | Shares |  | Price |  | Shares |  | Price
Outstanding at beginning of year |  |  | 50,106,287 |  |  | $ | 0.31 |  |  |  |  |  |  |  |  |  |  |  | 3,217,240 |  |  | $ | 1.49 |  |  |  | 3,092,417 |  |  | $ | 1.91 |
Granted |  |  | 37,485,000 |  |  |  | 0.58 |  |  |  |  |  |  |  |  |  |  |  | 48,070,000 |  |  |  | 0.26 |  |  |  | 1,087,700 |  |  |  | 1.45 |
Exercised |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |  |  |  | — |  |  |  | — |  |  |  | (37,786 | ) |  |  | 1.24 |
Expired or Forfeited |  |  | (1,308,779 | ) |  |  | 0.74 |  |  |  |  |  |  |  |  |  |  |  | (1,180,953 | ) |  |  | 1.63 |  |  |  | (925,091 | ) |  |  | 2.85 |
Outstanding at end of year |  |  | 86,282,508 |  |  |  | 0.42 |  |  |  | 8.20 |  |  | $ | 14,555,918 |  |  |  | 50,106,287 |  |  |  | 0.31 |  |  |  | 3,217,240 |  |  |  | 1.49 |
Options exercisable at year end |  |  | 22,646,940 |  |  |  | 0.38 |  |  |  | 7.13 |  |  | $ | 5,137,054 |  |  |  | 6,740,497 |  |  |  | 0.53 |  |  |  | 1,316,567 |  |  |  | 1.72 |
Options vested or expected to vest |  |  | 85,471,879 |  |  |  | 0.42 |  |  |  | 8.20 |  |  | $ | 14,466,053 |  |  |  | 49,434,997 |  |  |  | 0.31 |  |  |  |  |  |  |  |  |
Shares available for future grant at year end |  |  | 20,471,897 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 44,261,608 |  |  |  |  |  |  |  | 2,039,549 |  |  |  |  |
Weighted-average fair value of stock options granted during the year |  |  |  |  |  | $ | 0.46 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ | 0.21 |  |  |  |  |  |  | $ | 1.39 |
Stock options outstanding |
|  | OPTIONS OUTSTANDING |  | OPTIONS EXERCISABLE
|  |  |  | Weighted- |  |  |  |  |  |
|  |  |  | Average |  | Weighted- |  |  |  | Weighted-
|  |  |  | Remaining |  | Average |  |  |  | Average
Range of |  | Number |  | Contractual |  | Exercise |  | Number |  | Exercise
Exercise Prices |  | Outstanding |  | Life (Years) |  | Price |  | Exercisable |  | Price
| $0.19 - $0.19 |  |  |  | 162,500 |  |  |  | 5.61 |  |  | $ | 0.19 |  |  |  | 91,667 |  |  | $ | 0.19 |
| $0.26 - $0.26 |  |  |  | 47,022,303 |  |  |  | 7.33 |  |  |  | 0.26 |  |  |  | 17,200,939 |  |  |  | 0.26 |
| $0.32 - $0.53 |  |  |  | 11,285,000 |  |  |  | 9.71 |  |  |  | 0.47 |  |  |  | 546,875 |  |  |  | 0.34 |
| $0.58 - $0.61 |  |  |  | 2,046,436 |  |  |  | 4.93 |  |  |  | 0.59 |  |  |  | 1,764,145 |  |  |  | 0.59 |
| $0.62 - $0.62 |  |  |  | 10,400,000 |  |  |  | 9.79 |  |  |  | 0.62 |  |  |  | — |  |  |  | — |
| $0.63 - $0.63 |  |  |  | 10,000,000 |  |  |  | 9.46 |  |  |  | 0.63 |  |  |  | 1,708,334 |  |  |  | 0.63 |
| $0.64 - $6.96 |  |  |  | 5,355,769 |  |  |  | 8.59 |  |  |  | 0.84 |  |  |  | 1,324,480 |  |  |  | 1.36 |
| $7.00 - $7.00 |  |  |  | 5,000 |  |  |  | 0.67 |  |  |  | 7.00 |  |  |  | 5,000 |  |  |  | 7.00 |
| $9.80 - $9.80 |  |  |  | 3,000 |  |  |  | 1.04 |  |  |  | 9.80 |  |  |  | 3,000 |  |  |  | 9.80 |
| $11.756 - $11.756 |  |  |  | 2,500 |  |  |  | 1.40 |  |  |  | 11.76 |  |  |  | 2,500 |  |  |  | 11.76 |
| $0.19 - $11.756 |  |  |  | 86,282,508 |  |  |  | 8.20 |  |  | $ | 0.42 |  |  |  | 22,646,940 |  |  | $ | 0.38 |
Warrants outstanding |
|  | Number of Shares Exercisable |  | Exercise Price |  | Expiration Date
Issued to private placement investors in October 2009 |  |  | 3,977,270 |  |  | $ | 0.88 |  |  | 1/7/2015
Issued to private placement investors in July 2011 |  |  | 80,000,005 |  |  | $ | 0.18 |  |  | 7/1/2016
Other |  |  | 400,000 |  |  | $ | 0.69 |  |  | 8/1/2015
Total warrants outstanding at December 31, 2012 |  |  | 84,377,275 |  |  | $ | 0.21 | * |  |
* Average exercise price |  |  |  |  |  |  |  |  |  |
Common shares reserved for future issuance |
|  | No. of Shares
Issuance upon exercise of outstanding stock options |  |  | 86,282,508 |
Issuance of future grants under stock option plans |  |  | 20,471,897 |
Issuance of future grants under employee stock purchase plan |  |  | 445,701 |
Issuance of common stock related to convertible notes* |  |  | 197,686,842 |
Issuance upon exercise of warrants |  |  | 84,377,275 |
Total |  |  | 389,264,223 |
* Assumes all interest payments are paid-in-kind through the maturity date.

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