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NOTE 8 STOCKHOLDERS' EQUITY - Stock-based compensation expense (Details) (USD $) In Thousands, except Per Share data, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010
Operating expenses: |  |  |
Research and development | $ 1,585 | $ 819 | $ 398
General and administrative | 4,147 | 1,071 | 1,351
Total stock-based compensation expense | $ 5,732 | $ 1,890 | $ 1,749
Impact on basic and diluted net loss per common share | $ 0.02 | $ 0.02 | $ 0.04

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