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NOTE 8 STOCKHOLDERS' EQUITY (Tables)

12 Months Ended

Dec. 31, 2012

Equity [Abstract]

Stock option valuation assumptions

		2012				2011				2010
Expected term (years):
Stock options			5.51				5.00				6.00
Employee Stock Purchase Plan			.49				.50				.50
Risk-free interest rate:
Stock options			0.8	%			1.6	%			2.6	%
Employee Stock Purchase Plan			0.2	%			0.8	%			0.2	%
Volatility:
Stock options			106	%			106	%			164	%
Employee Stock Purchase Plan			0.8	%			142	%			92	%

Stock-based compensation expense (in thousands, except per share amounts)

For the Years Ended December 31,		2012				2011				2010
Research and development		$	1,585			$	819			$	398
General and administrative			4,147				1,071				1,351
Total		$	5,732			$	1,890			$	1,749
Impact on basic and diluted net loss per common share		$	0.02			$	0.02			$	0.04

Stock option activity

		2012																2011								2010
										Weighted-				Aggregate
						Weighted-				Average				Intrinsic								Weighted-								Weighted-
						Average				Remaining				Value as of								Average								Average
						Exercise				Contractual				December 31,								Exercise								Exercise
		Shares				Price				Term (Years)				2012				Shares				Price				Shares				Price
Outstanding at beginning of year			50,106,287			$	0.31												3,217,240			$	1.49				3,092,417			$	1.91
Granted			37,485,000				0.58												48,070,000				0.26				1,087,700				1.45
Exercised			—				—												—				—				(37,786	)			1.24
Expired or Forfeited			(1,308,779	)			0.74												(1,180,953	)			1.63				(925,091	)			2.85
Outstanding at end of year			86,282,508				0.42				8.20			$	14,555,918				50,106,287				0.31				3,217,240				1.49
Options exercisable at year end			22,646,940				0.38				7.13			$	5,137,054				6,740,497				0.53				1,316,567				1.72
Options vested or expected to vest			85,471,879				0.42				8.20			$	14,466,053				49,434,997				0.31
Shares available for future grant at year end			20,471,897																44,261,608								2,039,549
Weighted-average fair value of stock options granted during the year						$	0.46															$	0.21							$	1.39

Stock options outstanding

				OPTIONS OUTSTANDING												OPTIONS EXERCISABLE
								Weighted-
								Average				Weighted-								Weighted-
								Remaining				Average								Average
Range of				Number				Contractual				Exercise				Number				Exercise
Exercise Prices				Outstanding				Life (Years)				Price				Exercisable				Price
	$0.19 - $0.19				162,500				5.61			$	0.19				91,667			$	0.19
	$0.26 - $0.26				47,022,303				7.33				0.26				17,200,939				0.26
	$0.32 - $0.53				11,285,000				9.71				0.47				546,875				0.34
	$0.58 - $0.61				2,046,436				4.93				0.59				1,764,145				0.59
	$0.62 - $0.62				10,400,000				9.79				0.62				—				—
	$0.63 - $0.63				10,000,000				9.46				0.63				1,708,334				0.63
	$0.64 - $6.96				5,355,769				8.59				0.84				1,324,480				1.36
	$7.00 - $7.00				5,000				0.67				7.00				5,000				7.00
	$9.80 - $9.80				3,000				1.04				9.80				3,000				9.80
	$11.756 - $11.756				2,500				1.40				11.76				2,500				11.76
	$0.19 - $11.756				86,282,508				8.20			$	0.42				22,646,940			$	0.38

Warrants outstanding

		Number of Shares Exercisable				Exercise Price				Expiration Date
Issued to private placement investors in October 2009			3,977,270			$	0.88			1/7/2015
Issued to private placement investors in July 2011			80,000,005			$	0.18			7/1/2016
Other			400,000			$	0.69			8/1/2015
Total warrants outstanding at December 31, 2012			84,377,275			$	0.21	*
* Average exercise price

Common shares reserved for future issuance

		No. of Shares
Issuance upon exercise of outstanding stock options			86,282,508
Issuance of future grants under stock option plans			20,471,897
Issuance of future grants under employee stock purchase plan			445,701
Issuance of common stock related to convertible notes*			197,686,842
Issuance upon exercise of warrants			84,377,275
Total			389,264,223
* Assumes all interest payments are paid-in-kind through the maturity date.

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