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Note 5 - Stock-Based Compensation (Tables)
9 Months Ended
Sep. 30, 2013
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]
   

Three Months Ended

September 30,

   

Nine Months Ended

September 30,

 
   

2013

   

2012

   

2013

   

2012

 
                                 

Operating expenses:

                               

Research and development

  $ 544     $ 397     $ 1,088     $ 1,061  

General and administrative

    3,551       1,583       7,245       2,712  

Total stock-based compensation expense

  $ 4,095     $ 1,980     $ 8,333     $ 3,773  
                                 

Impact on basic and diluted net loss per common share

  $ 0.01     $ 0.01     $ 0.03     $ 0.02  
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]
   

Shares (in thousands)

   

Weighted- Average Exercise

Price

   

Weighted-

Average

Remaining Contractual Term

(Years)

 
                         

Outstanding at January 1, 2013

    86,478     $ 0.42       8.2  

Granted

    76,735     $ 0.40          

Exercised

    (4,323 )   $ 0.26          

Expired and forfeited

    (33,498 )   $ 0.47          

Outstanding at September 30, 2013

    125,392     $ 0.40       8.0