<SEC-DOCUMENT>0001019056-13-000222.txt : 20130214
<SEC-HEADER>0001019056-13-000222.hdr.sgml : 20130214
<ACCEPTANCE-DATETIME>20130214134917
ACCESSION NUMBER:		0001019056-13-000222
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20130214
DATE AS OF CHANGE:		20130214
GROUP MEMBERS:		JOSEPH EDELMAN
GROUP MEMBERS:		PERCEPTIVE ADVISORS LLC

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AP PHARMA INC /DE/
		CENTRAL INDEX KEY:			0000818033
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				942875566
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-39444
		FILM NUMBER:		13610656

	BUSINESS ADDRESS:	
		STREET 1:		123 SAGINAW DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063
		BUSINESS PHONE:		6503662626

	MAIL ADDRESS:	
		STREET 1:		123 SAGINAW DRIVE
		STREET 2:		123 SAGINAW DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADVANCED POLYMER SYSTEMS INC /DE/
		DATE OF NAME CHANGE:	19920703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PERCEPTIVE ADVISORS LLC
		CENTRAL INDEX KEY:			0001224962
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		499 PARK AVENUE, 25TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		646-205-5340

	MAIL ADDRESS:	
		STREET 1:		499 PARK AVENUE, 25TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>appharma_13ga1.htm
<DESCRIPTION>SCHEDULE 13G/A
<TEXT>
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<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-weight: normal">&nbsp;UNITED
STATES</FONT><BR>
<FONT STYLE="font-weight: normal">SECURITIES AND EXCHANGE COMMISSION</FONT></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-weight: normal">Washington, D.C. 20549</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 18pt Times New Roman, Times, Serif; margin: 0; text-align: center">SCHEDULE 13G/A</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Amendment No. 1)</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0; text-align: center">Under the Securities Exchange Act of 1934</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 24pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>A.P. Pharma, Inc.</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">Common Stock</P>

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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-size: 10pt">(Title of Class
of Securities)</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-size: 10pt"><B>00202J203</B></FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">December 31, 2012</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Date of Event Which Requires Filing of this
Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Check the appropriate box to designate the rule pursuant to which
this Schedule is filed:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 8%; font-family: Wingdings"><FONT STYLE="font: 10pt Wingdings 2">&#83;</FONT></TD>
    <TD STYLE="width: 92%; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">Rule 13d-1(b)</FONT></TD></TR>
<TR>
    <TD STYLE="font: 10pt Wingdings"><FONT STYLE="font: 10pt Wingdings 2">&#163;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">Rule 13d-1(c)</FONT></TD></TR>
<TR>
    <TD STYLE="font: 10pt Wingdings"><FONT STYLE="font: 10pt Wingdings 2">&#163;</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">Rule 13d-1(d)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">*The remainder of this cover page shall be
filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent
amendment containing information which would alter the disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The information required in the remainder of
this cover page shall not be deemed to be &quot;filed&quot; for the purpose of Section 18 of the Securities Exchange Act of 1934
(&quot;Act&quot;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions
of the Act (however, see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Persons who are to respond to the collection
of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font-weight: normal">SEC 1745
(12-02)</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>



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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 32%; border: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt">CUSIP No. 00202J203</TD>
    <TD STYLE="width: 35%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font-size: 10pt; font-weight: bold; text-align: center">13G/A</TD>
    <TD STYLE="width: 33%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Page 2 of 7 Pages</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-family: Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; font-weight: bold; border: Black 1pt solid; padding: 5pt"><FONT STYLE="font-size: 10pt"><B>1.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 5pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">names of reporting persons</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">i.r.s. identification no.
        of above persons (entities only)</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>
        <P STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; margin: 0">Perceptive Advisors LLC</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; font-weight: bold; border-right: Black 1pt solid; border-left: Black 1pt solid; padding: 5pt"><FONT STYLE="font-size: 10pt"><B>2.</B></FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 5pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">check the appropriate
box if a group*</FONT>
</P></TD>
    <TD STYLE="font-size: 10pt; border-right: Black 1pt solid; padding: 5pt"><FONT STYLE="font-size: 10pt">(a)
<FONT STYLE="font-family: Wingdings 2">&#163;</FONT> </FONT><BR>
<FONT STYLE="font-size: 10pt">(b) <FONT STYLE="font-family: Wingdings 2">&#163;</FONT></FONT></TD>
</TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; font-weight: bold; border: Black 1pt solid; padding: 5pt"><FONT STYLE="font-size: 10pt"><B>3.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 5pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">sec use only</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; font-weight: bold; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 5pt"><FONT STYLE="font-size: 10pt"><B>4.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 5pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">citizenship or place of organization</FONT></P>
        <P STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">Delaware, United States of America</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-variant: small-caps; text-align: center; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; vertical-align: bottom"><B>number of <BR>
shares</B></TD>
    <TD STYLE="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid; border-left: Black 1pt solid; border-right: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; text-align: center; vertical-align: middle"><FONT STYLE="font-size: 10pt"><B>5.</B></FONT></TD>
    <TD STYLE="font-size: 10pt; font-variant: small-caps; border-bottom: Black 1pt solid; padding-right: 5pt; padding-left: 5pt">sole voting power</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-variant: small-caps; font-weight: bold; text-align: right; border-bottom: Black 1pt solid; border-left: Black 1pt solid; border-right: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; vertical-align: middle">0</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-variant: small-caps; text-align: center; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; vertical-align: top"><B>beneficially <BR>
owned by</B></TD>
    <TD STYLE="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid; border-left: Black 1pt solid; border-right: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; text-align: center; vertical-align: middle"><FONT STYLE="font-size: 10pt"><B>6.</B></FONT></TD>
    <TD STYLE="font-size: 10pt; font-variant: small-caps; border-bottom: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; text-align: left; vertical-align: middle">shared voting power</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-variant: small-caps; font-weight: bold; text-align: right; border-bottom: Black 1pt solid; border-left: Black 1pt solid; border-right: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; vertical-align: middle">31,504,199*</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-variant: small-caps; text-align: center; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; vertical-align: top"><B>each <BR>
reporting</B></TD>
    <TD STYLE="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid; border-left: Black 1pt solid; border-right: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; text-align: center; vertical-align: middle"><FONT STYLE="font-size: 10pt"><B>7.</B></FONT></TD>
    <TD STYLE="font-size: 10pt; font-variant: small-caps; border-bottom: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; text-align: left; vertical-align: middle">sole dispositive power</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-variant: small-caps; font-weight: bold; text-align: right; border-bottom: Black 1pt solid; border-left: Black 1pt solid; border-right: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; vertical-align: middle">0</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-variant: small-caps; text-align: center; border-left: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; vertical-align: top"><B>person with:</B></TD>
    <TD STYLE="font-size: 10pt; font-weight: bold; border-right: Black 1pt solid; border-left: Black 1pt solid; padding: 3pt 5pt; text-align: center; vertical-align: middle"><FONT STYLE="font-size: 10pt"><B>8.</B></FONT></TD>
    <TD STYLE="font-size: 10pt; font-variant: small-caps; padding: 3pt 5pt; text-align: left; vertical-align: middle">shared dispostive power</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-variant: small-caps; font-weight: bold; text-align: right; border-right: Black 1pt solid; padding: 3pt 5pt; vertical-align: middle">31,504,199*</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; font-weight: bold; border: Black 1pt solid; padding: 5pt"><FONT STYLE="font-size: 10pt"><B>9.</B></FONT></TD>
    <TD COLSPAN="4" STYLE="font-size: 10pt; font-variant: small-caps; border-top: Black 1pt solid; border-bottom: Black 1pt solid; padding: 5pt">aggregate amount beneficially owned by each reporting person</TD>
    <TD STYLE="font-size: 10pt; font-variant: small-caps; font-weight: bold; text-align: right; border: Black 1pt solid; padding: 5pt; vertical-align: middle">31,504,199*</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; font-weight: bold; border-left: Black 1pt solid; padding: 5pt; border-right: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>10.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="font-size: 10pt; font-variant: small-caps; padding: 5pt; border-right: Black 1pt solid"><FONT STYLE="font-variant: small-caps">check box if the aggregate amount in row (9) excludes certain shares (See Instructions) <FONT STYLE="font-family: Symbol"><FONT STYLE="font-family: Wingdings 2">&#163;</FONT></FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; font-weight: bold; border: Black 1pt solid; padding: 5pt"><FONT STYLE="font-size: 10pt"><B>11.</B></FONT></TD>
    <TD COLSPAN="4" STYLE="font-size: 10pt; font-variant: small-caps; border-top: Black 1pt solid; border-bottom: Black 1pt solid; padding: 5pt">percent of class represented by amount in row (9)</TD>
    <TD STYLE="font-size: 10pt; font-variant: small-caps; font-weight: bold; text-align: right; border: Black 1pt solid; padding: 5pt">9.99%*</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 5pt; border-right: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>12.</B></FONT></TD>
    <TD COLSPAN="4" STYLE="font-size: 10pt; font-variant: small-caps; border-bottom: Black 1pt solid; padding: 5pt">type of reporting person (See Instructions)</TD>
    <TD STYLE="font-size: 10pt; font-variant: small-caps; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding: 5pt; border-right: Black 1pt solid; text-align: center"><FONT STYLE="font-variant: small-caps">&#9;<B>IA</B></FONT></TD></TR>
<TR>
    <TD STYLE="width: 6%">&nbsp;</TD>
    <TD STYLE="width: 17%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 51%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 16%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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    <TD STYLE="border: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; width: 32%">CUSIP No. 00202J203</TD>
    <TD STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font-size: 10pt; font-weight: bold; text-align: center; width: 35%">13G/A</TD>
    <TD STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; width: 33%">Page
    3  of 7 Pages</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-weight: bold; text-align: left; border: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>13.</B></FONT></TD>
    <TD COLSPAN="7" STYLE="vertical-align: top; padding: 5pt; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">names of reporting persons</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">i.r.s. identification no.
        of above persons (entities only)</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>
        <P STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; margin: 0">Joseph Edelman</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P></TD>
    </TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-weight: bold; text-align: left; border-right: Black 1pt solid; border-left: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>14.</B></FONT></TD>
    <TD COLSPAN="6" STYLE="vertical-align: top; padding: 5pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">check the appropriate
box if a group*</FONT></P></TD>
    <TD STYLE="font-size: 10pt; padding: 5pt; border-right: Black 1pt solid"><FONT STYLE="font-size: 10pt">(a)
<FONT STYLE="font-family: Wingdings 2">&#163;</FONT> </FONT><BR>
<FONT STYLE="font-size: 10pt">(b) <FONT STYLE="font-family: Wingdings 2">&#163;</FONT></FONT></TD>

    </TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-weight: bold; text-align: left; border-right: Black 1pt solid; border-left: Black 1pt solid; border-top: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>15.</B></FONT></TD>
    <TD COLSPAN="7" STYLE="vertical-align: top; padding: 5pt; border-right: Black 1pt solid; border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">sec use only</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P></TD>
    </TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-weight: bold; text-align: left; border: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>16.</B></FONT></TD>
    <TD COLSPAN="7" STYLE="vertical-align: top; padding: 5pt; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-top: Black 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">citizenship or place of organization</FONT></P>
        <P STYLE="font: small-caps bold 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">United States of America</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P></TD>
    </TR>
<TR>
    <TD COLSPAN="3" STYLE="vertical-align: top; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; font-size: 10pt; font-variant: small-caps; text-align: center"><B>number
    of<BR> shares</B></TD>
    <TD STYLE="vertical-align: middle; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center"><FONT STYLE="font-size: 10pt"><B>17.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: left; border-bottom: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; font-size: 10pt; font-variant: small-caps; vertical-align: middle">sole voting power</TD>
    <TD COLSPAN="3" STYLE="vertical-align: middle; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; font-size: 10pt; font-variant: small-caps; font-weight: bold; text-align: right">0</TD>
    </TR>
<TR>
    <TD COLSPAN="3" STYLE="vertical-align: top; padding-right: 5pt; padding-left: 5pt; font-size: 10pt; font-variant: small-caps; text-align: center; border-left: Black 1pt solid"><B>beneficially<BR>
    owned by</B></TD>
    <TD STYLE="vertical-align: middle; border-right: Black 1pt solid; border-left: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center"><FONT STYLE="font-size: 10pt"><B>18.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: left; padding-right: 5pt; padding-left: 5pt; font-size: 10pt; font-variant: small-caps; vertical-align: middle">shared voting power</TD>
    <TD COLSPAN="3" STYLE="vertical-align: middle; border-right: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; font-size: 10pt; font-variant: small-caps; font-weight: bold; text-align: right">31,504,199*</TD>
    </TR>
<TR>
    <TD COLSPAN="3" STYLE="vertical-align: top; border-top: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; font-size: 10pt; font-variant: small-caps; text-align: center"><B>each<BR>
    reporting</B></TD>
    <TD STYLE="vertical-align: middle; border: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center"><FONT STYLE="font-size: 10pt"><B>19.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: left; border-top: Black 1pt solid; border-bottom: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; font-size: 10pt; font-variant: small-caps; vertical-align: middle">sole dispositive power</TD>
    <TD COLSPAN="3" STYLE="vertical-align: middle; border: Black 1pt solid; padding-right: 5pt; padding-left: 5pt; font-size: 10pt; font-variant: small-caps; font-weight: bold; text-align: right">0</TD>
    </TR>
<TR>
    <TD COLSPAN="3" STYLE="vertical-align: top; border-bottom: Black 1pt solid; padding-right: 5pt; border-left: Black 1pt solid; padding-left: 5pt; font-size: 10pt; font-variant: small-caps; text-align: center"><B>person
    with:</B></TD>
    <TD STYLE="vertical-align: middle; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font-size: 10pt; font-weight: bold; text-align: center"><FONT STYLE="font-size: 10pt"><B>20.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: left; padding: 3pt 5pt 2pt; font-size: 10pt; font-variant: small-caps; border-bottom: Black 1pt solid; vertical-align: middle">shared dispostive power</TD>
    <TD COLSPAN="3" STYLE="vertical-align: middle; padding: 3pt 5pt 2pt; font-size: 10pt; font-variant: small-caps; font-weight: bold; text-align: right; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid">31,504,199*</TD>
    </TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-weight: bold; text-align: left; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>21.</B></FONT></TD>
    <TD COLSPAN="6" STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-variant: small-caps; border-bottom: Black 1pt solid">aggregate amount beneficially owned by each reporting person</TD>
    <TD STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-variant: small-caps; font-weight: bold; text-align: right; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid">31,504,199*</TD>
    </TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-weight: bold; text-align: left; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>22.</B></FONT></TD>
    <TD COLSPAN="7" STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-variant: small-caps; border-right: Black 1pt solid; border-bottom: Black 1pt solid"><FONT STYLE="font-variant: small-caps">check box if the aggregate amount in row (9) excludes certain shares (See Instructions)</FONT> <FONT STYLE="font-family: Wingdings 2">&#163;</FONT></TD>
    </TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-weight: bold; text-align: left; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>23.</B></FONT></TD>
    <TD COLSPAN="6" STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-variant: small-caps; border-bottom: Black 1pt solid">percent of class represented by amount in row (9)</TD>
    <TD STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-variant: small-caps; font-weight: bold; text-align: right; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid">9.99%*</TD>
    </TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-weight: bold; text-align: left; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid"><FONT STYLE="font-size: 10pt"><B>24.</B></FONT></TD>
    <TD COLSPAN="6" STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-variant: small-caps; border-bottom: Black 1pt solid">type of reporting person (See Instructions)</TD>
    <TD STYLE="vertical-align: top; padding: 5pt; font-size: 10pt; font-variant: small-caps; border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; text-align: center"><FONT STYLE="font-variant: small-caps">&#9;<B>IN</B></FONT></TD>
    </TR>
<TR>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD>
    <TD STYLE="width: 5%; text-align: left">&nbsp;</TD>
    <TD STYLE="width: 18%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 15%">&nbsp;</TD>
    <TD STYLE="width: 30%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 7%">&nbsp;</TD>
    <TD STYLE="width: 18%">&nbsp;</TD>
    </TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

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<P STYLE="margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="5" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="border: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; width: 32%">CUSIP No. 00202J203</TD>
    <TD STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font-size: 10pt; font-weight: bold; text-align: center; width: 35%">13G/A</TD>
    <TD STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; width: 33%">Page
    4  of 7 Pages</TD></TR>
</TABLE>

<P STYLE="margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="10" STYLE="font-weight: bold">Item 1.</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="10" STYLE="font-weight: bold">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left; vertical-align: top">(a) Name of Issuer:</TD>
    <TD COLSPAN="5" STYLE="font-weight: bold">A.P. Pharma, Inc.</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="font-weight: bold">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="6" STYLE="text-align: left; vertical-align: top">(b) Address of Issuer's Principal Executive Offices:</TD>
    <TD COLSPAN="3">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>123 Saginaw Drive</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Redwood City<FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>, CA 94063</B></FONT></B></P></TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="10">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="10" STYLE="font-weight: bold">Item 2.</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="10" STYLE="font-weight: bold">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="5" STYLE="text-align: left; vertical-align: top">(a) Name of Person Filing:</TD>
    <TD COLSPAN="4"><B>This Schedule 13G/A (the &ldquo;Schedule&rdquo;) is being filed with respect to shares of Common Stock (as
defined below) of <FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>A.P. Pharma, Inc.</B><FONT STYLE="font-weight: normal">
(</FONT><B>the &ldquo;Issuer&rdquo;) which are beneficially owned by Perceptive Advisors LLC and Joseph Edelman (together, the
&ldquo;Reporting Persons&rdquo;). See Item 4 below.</B></FONT></B></TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="5" STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: left; vertical-align: top">(b) Address of Principal Business Office or, if none, Residence:</TD>
    <TD COLSPAN="2">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>499 Park Avenue, 25<SUP>th</SUP> Floor</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>New York, NY 10022</B></P></TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD></TD>
    <TD COLSPAN="5" STYLE="text-align: left; vertical-align: top">(c)&nbsp; Citizenship:</TD>
    <TD COLSPAN="4" STYLE="font-weight: bold; text-align: justify">Perceptive Advisors LLC is a Delaware limited liability company and Joseph Edelman is a United States Citizen.</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="5" STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="font-weight: bold; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD></TD>
    <TD COLSPAN="5" STYLE="text-align: left; vertical-align: top">(d)&nbsp; Title of Class of Securities:</TD>
    <TD COLSPAN="4" STYLE="font-weight: bold">Common Stock</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="5" STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="font-weight: bold">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD></TD>
    <TD COLSPAN="5" STYLE="text-align: left; vertical-align: top">(e)&nbsp; CUSIP Number:</TD>
    <TD COLSPAN="4" STYLE="font-weight: bold">00202J203</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="5" STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="font-weight: bold">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; font-weight: bold">Item 3.</TD>
    <TD COLSPAN="8" STYLE="font-weight: bold">If this statement is filed pursuant to &sect;&sect;240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="8" STYLE="font-weight: bold">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right; vertical-align: top">(a)&nbsp;&nbsp;&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">[ ]</TD>
    <TD COLSPAN="7" STYLE="text-align: justify">Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right; vertical-align: top">(b)&nbsp;&nbsp;&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">[ ]</TD>
    <TD COLSPAN="7" STYLE="text-align: justify">Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right; vertical-align: top">(c)&nbsp;&nbsp;&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">[ ]</TD>
    <TD COLSPAN="7">Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="7">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right; vertical-align: top">(d)&nbsp;&nbsp;&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">[ ]</TD>
    <TD COLSPAN="7" STYLE="text-align: justify">Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8).</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right; vertical-align: top">(e)&nbsp;&nbsp;&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">[X]</TD>
    <TD COLSPAN="7">An investment adviser in accordance with &sect;240.13d-1(b)(1)(ii)(E);</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="7">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right; vertical-align: top">(f)&nbsp;&nbsp;&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">[ ]</TD>
    <TD COLSPAN="7">An employee benefit plan or endowment fund in accordance with &sect;240.13d-1(b)(1)(ii)(F);</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="7">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right; vertical-align: top">(g)&nbsp;&nbsp;&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">[ ]</TD>
    <TD COLSPAN="7">A parent holding company or control person in accordance with &sect; 240.13d-1(b)(1)(ii)(G);</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="7">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right; vertical-align: top">(h)&nbsp;&nbsp;&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">[ ]</TD>
    <TD COLSPAN="7" STYLE="text-align: justify">A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right; vertical-align: top">(i)&nbsp;&nbsp;&nbsp;&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">[ ]</TD>
    <TD COLSPAN="7" STYLE="text-align: justify">A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right; vertical-align: top">&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: right; vertical-align: top">(j)&nbsp;&nbsp;&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: top">[ ]</TD>
    <TD COLSPAN="7">Group, in accordance with &sect;240.13d-1(b)(1)(ii)(J).</TD></TR>
<TR>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 3%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 7%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 15%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 2%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 18%">&nbsp;</TD>
    <TD STYLE="width: 7%">&nbsp;</TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 38%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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    <TD STYLE="width: 32%; border: windowtext 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">CUSIP No. 00202J203</FONT></TD>
    <TD STYLE="width: 32%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font-weight: bold; text-align: center">13G/A</TD>
    <TD STYLE="width: 36%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Page 5 of 7 Pages</TD></TR>
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<TR>
    <TD COLSPAN="2" STYLE="font-weight: bold; text-align: justify">Item 4.</TD>
    <TD COLSPAN="8" STYLE="font-weight: bold; text-align: justify">Ownership.</TD></TR>
<TR>
    <TD COLSPAN="10">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 37.45pt">Provide the following information regarding
        the aggregate number and percentage of the class of securities of the issuer identified in Item 1.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">(a)</TD>
    <TD COLSPAN="4" STYLE="text-align: left; vertical-align: top">Amount beneficially owned:</TD>
    <TD COLSPAN="5" STYLE="text-align: justify">The Reporting Persons beneficially own <FONT STYLE="font-variant: small-caps">31,504,199*<FONT STYLE="font: 12pt Times New Roman, Times, Serif"><B>
</B></FONT></FONT><FONT STYLE="font-size: 10pt">shares of Common Stock held by a private investment fund (the &ldquo;Fund&rdquo;)
to which Perceptive Advisors LLC serves as the investment manager, which includes 18,352,404 shares of Common Stock and 13,151,795
shares underlying Common Stock purchase warrants held by the Reporting Persons. Mr. Edelman is the managing member of Perceptive
Advisors LLC.</FONT></TD></TR>
<TR>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">(b)</TD>
    <TD COLSPAN="4" STYLE="text-align: left; vertical-align: top">Percent of class:</TD>
    <TD COLSPAN="5" STYLE="text-align: justify">The beneficial ownership of 9.99% is based on the sum of 302,205,555 shares of Common Stock as reflected on
the Issuer&rsquo;s 10-Q on November 5, 2012 and the number of Warrants owned by the Reporting Persons.*</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="text-align: justify">*Excludes 181,538.5 shares underlying Common Stock purchase warrants held by the Reporting Persons. These
warrants are not presently exercisable due to an exercisability limitation included in the Warrant which provides that the warrants
are not exercisable (i) while the holder is a beneficial owner of over 9.99 % of the shares of the Issuer or (ii) to the extent
that such exercise would cause the holder&rsquo;s beneficial ownership to exceed 9.99%.</TD></TR>
<TR>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">(c)</TD>
    <TD COLSPAN="9" STYLE="text-align: justify">Number of shares as to which the person has:</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="9" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left; vertical-align: top">(i)</TD>
    <TD COLSPAN="5" STYLE="text-align: left; vertical-align: top">Sole power to vote or to direct the vote:</TD>
    <TD COLSPAN="2" NOWRAP STYLE="vertical-align: top; font-variant: small-caps; text-align: right">0</TD></TR>
<TR>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="text-align: justify">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; font-variant: small-caps; text-align: right">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left; vertical-align: top">(ii)</TD>
    <TD COLSPAN="5" STYLE="text-align: left; vertical-align: top">Shared power to vote or to direct the vote:</TD>
    <TD COLSPAN="2" NOWRAP STYLE="vertical-align: top; text-align: right">31,504,199</TD></TR>
<TR>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="text-align: justify">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; text-align: right">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left; vertical-align: top">(iii)</TD>
    <TD COLSPAN="5" STYLE="text-align: left; vertical-align: top">Sole power to dispose or to direct the disposition of:</TD>
    <TD COLSPAN="2" NOWRAP STYLE="vertical-align: top; font-variant: small-caps; text-align: right">0</TD></TR>
<TR>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="text-align: justify">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; font-variant: small-caps; text-align: right">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left; vertical-align: top">(iv)</TD>
    <TD COLSPAN="5" STYLE="text-align: left; vertical-align: top">Shared power to dispose or to direct the disposition of:</TD>
    <TD COLSPAN="2" NOWRAP STYLE="vertical-align: top; text-align: right"><FONT STYLE="font-variant: small-caps">31,504,199</FONT></TD></TR>
<TR>
    <TD COLSPAN="10">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P></TD></TR>
<TR>
    <TD><B>Item 5 </B></TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="8"><B>Ownership of Five Percent or Less of a Class</B></TD></TR>
<TR>
    <TD COLSPAN="10">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="10">If this statement is being filed to report the fact that as of the date hereof
    the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the
    following: <FONT STYLE="font-family: Wingdings 2">&#163;</FONT>.</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="8" STYLE="font-weight: bold">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="font-weight: bold">Item 6</TD>
    <TD COLSPAN="8" STYLE="font-weight: bold">Ownership of More Than Five Percent on Behalf of Another Person</TD></TR>
<TR>
    <TD COLSPAN="10">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="10">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The Fund described in Item 4 has the right
        to receive or the power to direct the receipt of dividends from, or the proceeds from, the sale of the securities held in its account.
        Filing of this statement by the Reporting Persons shall not be deemed an admission that they beneficially own the securities reported
        herein. The Reporting Persons expressly disclaim beneficial ownership of all securities reported herein.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="font-weight: bold; text-align: left; vertical-align: top">Item 7. </TD>
    <TD STYLE="font-weight: bold; text-align: justify">&nbsp;</TD>
    <TD COLSPAN="8" STYLE="font-weight: bold; text-align: justify">Identification and Classification of the Subsidiary which Acquired the Security Being Reported on by the Parent Holding Company
or Control Person.&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="10" STYLE="font-weight: bold; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="10">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Not applicable.</P></TD></TR>
<TR>
    <TD STYLE="width: 11%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 2%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 11%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 10%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 21%">&nbsp;</TD>
    <TD STYLE="width: 34%">&nbsp;</TD>
    <TD STYLE="width: 8%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"></P>

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    <TD STYLE="border: windowtext 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt; width: 32%"><FONT STYLE="font-size: 10pt">CUSIP No. 00202J203</FONT></TD>
    <TD STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font-weight: bold; text-align: center; width: 32%">13G/A</TD>
    <TD STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; width: 36%">Page
    6  of 7 Pages</TD></TR>
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<TR>
    <TD STYLE="font-weight: bold; text-align: justify">Item 8.&nbsp; </TD>
    <TD STYLE="font-weight: bold; text-align: justify">&nbsp;</TD>
    <TD COLSPAN="8" STYLE="font-weight: bold; text-align: justify">Identification and Classification of Members of the Group.</TD></TR>
<TR>
    <TD COLSPAN="10" STYLE="font-weight: bold; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="10">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Not applicable.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="font-weight: bold; text-align: justify">Item 9. </TD>
    <TD STYLE="font-weight: bold; text-align: justify">&nbsp;</TD>
    <TD COLSPAN="8" STYLE="font-weight: bold; text-align: justify">Notice of Dissolution of Group.</TD></TR>
<TR>
    <TD COLSPAN="10">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">Not applicable.&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="width: 11%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 2%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 8%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 8%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 4%; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 7%">&nbsp;</TD>
    <TD STYLE="width: 21%">&nbsp;</TD>
    <TD STYLE="width: 4%">&nbsp;</TD>
    <TD STYLE="width: 34%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-family: Times New Roman, Times, Serif">
<TR>
    <TD STYLE="font-size: 10pt; font-weight: bold">Item 10.</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt; font-weight: bold">Certification</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">(a)</TD>
    <TD COLSPAN="2">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0">The following certification
        shall be included if the statement is filed pursuant to &sect;240.13d-1(b):</P>
</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt; text-align: left; vertical-align: top"></TD>
    <TD COLSPAN="2">        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in; text-align: justify">By signing below I certify that, to
        the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business
        and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer
        of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that
        purpose or effect. <FONT STYLE="font-family: Wingdings 2">&#83;</FONT></P></TD></TR>
<TR>
    <TD STYLE="width: 13%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 86%">&nbsp;</TD></TR>
</TABLE>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 33%; border: windowtext 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">CUSIP No. 00202J203</FONT></TD>
    <TD STYLE="width: 34%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font-weight: bold; text-align: center">13G/A</TD>
    <TD STYLE="width: 33%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">Page 7 of 7 Pages</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">SIGNATURE</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE ALIGN="CENTER" CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-family: Times New Roman, Times, Serif">
<TR>
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 50%; font-size: 10pt; text-align: left"><U>February 14, 2013</U></TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">Date</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left"> PERCEPTIVE ADVISORS LLC</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">/s/ Joseph Edelman</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">Signature</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">Joseph Edelman/Managing Member</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">Name/Title</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left"><U>February 14, 2013</U></TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">Date</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">/s/ Joseph Edelman</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">Signature </TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">Joseph Edelman</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">Name/Title</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The original statement shall be signed by each
person on whose behalf the statement is filed or his authorized representative. If the statement is signed on behalf of a person
by his authorized representative other than an executive officer or general partner of the filing person, evidence of the representative's
authority to sign on behalf of such person shall be filed with the statement, provided, however, that a power of attorney for this
purpose which is already on file with the Commission may be incorporated by reference. The name and any title of each person who
signs the statement shall be typed or printed beneath his signature.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><I>NOTE</I>: Schedules filed in paper format
shall include a signed original and five copies of the schedule, including all exhibits. <I>See</I> &sect;240.13d-7 for other parties
for whom copies are to be sent.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-family: Times New Roman, Times, Serif">
<TR>
    <TD STYLE="vertical-align: top; width: 10%; font-size: 10pt; font-weight: bold">Attention:</TD>
    <TD STYLE="width: 90%; font-size: 10pt; font-weight: bold">Intentional misstatements or omissions of fact constitute Federal criminal violations (See 18 U.S.C. 1001)</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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