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Note 14 - Quarterly Results of Operations (Unaudited) (Details) - Quarterly Results of 2013 Operations (USD $) In Thousands, except Per Share data, unless otherwise specified | 3 Months Ended | 12 Months Ended
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Dec. 31, 2013 | Sep. 30, 2013 | Jun. 30, 2013 | Mar. 31, 2013 | Dec. 31, 2012 | Sep. 30, 2012 | Jun. 30, 2012 | Mar. 31, 2012 | Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Quarterly Results of 2013 Operations [Abstract] |  |  |  |  |  |  |  |  |  |  |
Total revenue | $ 0 | $ 0 | $ 0 | $ 0 | $ 0 | $ 0 | $ 0 | $ 0 |  |  | $ 646
Operating expenses | 13,832 | 12,664 | 15,209 | 12,752 | 8,628 | 6,054 | 4,380 | 4,769 | 54,457 | 23,831 | 11,708
Interest and other expense, net | (212) | (209) | (204) | (201) | (197) | (195) | (146) | (61) | (826) | (599) | (373)
Net loss | $ (14,044) | $ (12,873) | $ (15,413) | $ (12,953) | $ (7,737) | $ (6,121) | $ (4,569) | $ (4,921) | $ (55,283) | $ (23,348) | $ (11,814)
Net loss (in Dollars per share) | $ (0.75) | $ (0.84) | $ (1.01) | $ (0.85) | $ (0.51) | $ (0.45) | $ (0.46) | $ (0.49) | $ (3.42) | $ (1.91) | $ (1.96)

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