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Note 8 - Stockholders' Equity (Tables) | 12 Months Ended
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Dec. 31, 2013
Stockholders' Equity Note [Abstract] |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
For the Years Ended December 31, |  | 2013 |  |  | 2012 |  |  | 2011 |
Expected term (years): |  |  |  |  |  |  |  |  |  |  |  |
Stock options |  |  | 6.00 |  |  |  | 5.51 |  |  |  | 5.00 |
Employee Stock Purchase Plan |  |  | .49 |  |  |  | .49 |  |  |  | .50 |
Risk-free interest rate: |  |  |  |  |  |  |  |  |  |  |  |
Stock options |  |  | 1.5 | % |  |  | 0.8 | % |  |  | 1.6 | %
Employee Stock Purchase Plan |  |  | 0.8 | % |  |  | 0.2 | % |  |  | 0.8 | %
Volatility: |  |  |  |  |  |  |  |  |  |  |  |
Stock options |  |  | 105 | % |  |  | 106 | % |  |  | 106 | %
Employee Stock Purchase Plan |  |  | 212 | % |  |  | 0.8 | % |  |  | 142 | %
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] |
For the Years Ended December 31, |  | 2013 |  |  | 2012 |  |  | 2011 |
Research and development |  | $ | 2,562 |  |  | $ | 1,585 |  |  | $ | 819 |
General and adminstrative |  |  | 8,328 |  |  |  | 4,147 |  |  |  | 1,071 |
Total |  | $ | 10,890 |  |  | $ | 5,732 |  |  | $ | 1,890 |
Impact on basic and diluted net loss per common share |  | $ | 0.67 |  |  | $ | 0.47 |  |  | $ | 0.31 |
Schedule of Share-based Compensation, Activity [Table Text Block] |
|  | 2013 |  |  | 2012 |  |  | 2011 |
|  | Shares |  |  | Weighted- Average Exercise Price |  |  | Weighted- Average Remaining Contractual Term (Years) |  |  | Aggregate Intrinsic Value as of December 31, 2013 |  |  | Shares |  |  | Weighted- Average Exercise Price |  |  | Shares |  |  | Weighted- Average Exercise Price |
Outstanding at beginning of year |  |  | 4,323,874 |  |  | $ | 8.46 |  |  |  |  |  |  |  |  |  |  |  | 2,505,283 |  |  | $ | 6.13 |  |  |  | 160,833 |  |  | $ | 29.83 |
Granted |  |  | 4,256,971 |  |  |  | 8.08 |  |  |  |  |  |  |  |  |  |  |  | 1,874,246 |  |  |  | 11.61 |  |  |  | 2,403,495 |  |  |  | 5.19 |
Exercised |  |  | (537,029 | ) |  |  | 5.20 |  |  |  |  |  |  |  |  |  |  |  | - |  |  |  | - |  |  |  | - |  |  |  | - |
Expired or Forfeited |  |  | (1,688,135 | ) |  |  | 9.45 |  |  |  |  |  |  |  |  |  |  |  | (55,655 | ) |  |  | 9.56 |  |  |  | (59,045 | ) |  |  | 32.53 |
Outstanding at end of year |  |  | 6,355,681 |  |  |  | 8.22 |  |  |  | 8.14 |  |  | $ | 10,704,578 |  |  |  | 4,323,874 |  |  |  | 8.46 |  |  |  | 2,505,283 |  |  |  | 6.13 |
Options exercisable at year end |  |  | 1,770,597 |  |  |  | 8.67 |  |  |  | 5.12 |  |  | $ | 4,607,452 |  |  |  | 1,142,099 |  |  |  | 7.98 |  |  |  | 337,002 |  |  |  | 10.68 |
Options vested or expected to vest |  |  | 6,292,296 |  |  |  | 8.22 |  |  |  | 8.13 |  |  | $ | 10,614,670 |  |  |  | 4,283,344 |  |  |  | 8.45 |  |  |  | 2,471,725 |  |  |  | 6.14 |
Shares available for future grant at year end |  |  | 1,797,694 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,018,766 |  |  |  |  |  |  |  | 2,213,155 |  |  |  |  |
Weighted-average fair value of stock options granted during the year |  | $ |  |  |  |  | 8.08 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ | 11.61 |  |  |  |  |  |  | $ | 5.19 |
Schedule of Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding [Table Text Block] |
|  |  |  |  |  |  | OPTIONS OUTSTANDING |  |  | OPTIONS EXERCISABLE |
| Range of Exercise Prices |  |  | Number Outstanding |  |  | Weighted-Average Remaining Contractual Life (Years) |  |  | Weighted-Average Exercise Price |  |  | Number Exercisable |  |  | Weighted-Average Exercise Price |
|  | $3.80 | - | $3.80 |  |  |  | 5,000 |  |  |  | 7.99 |  |  | $ | 3.80 |  |  |  | 2,708 |  |  | $ | 3.80 |
|  | $5.20 | - | $5.20 |  |  |  | 1,072,887 |  |  |  | 4.02 |  |  |  | 5.20 |  |  |  | 997,934 |  |  |  | 5.20 |
|  | $6.40 | - | $7.00 |  |  |  | 386,613 |  |  |  | 8.60 |  |  |  | 6.85 |  |  |  | 80,210 |  |  |  | 6.66 |
|  | $7.20 | - | $7.20 |  |  |  | 3,190,240 |  |  |  | 9.34 |  |  |  | 7.20 |  |  |  | 41,012 |  |  |  | 7.20 |
|  | $7.40 | - | $10.60 |  |  |  | 852,372 |  |  |  | 9.38 |  |  |  | 9.89 |  |  |  | 105,881 |  |  |  | 10.57 |
|  | $11.00 | - | $15.00 |  |  |  | 730,285 |  |  |  | 7.54 |  |  |  | 13.15 |  |  |  | 499,642 |  |  |  | 12.79 |
|  | $15.40 | - | $130.40 |  |  |  | 117,598 |  |  |  | 6.44 |  |  |  | 24.14 |  |  |  | 42,524 |  |  |  | 39.54 |
|  | $139.20 | - | $139.20 |  |  |  | 125 |  |  |  | 1.08 |  |  |  | 139.20 |  |  |  | 125 |  |  |  | 139.20 |
|  | $196.00 | - | $196.00 |  |  |  | 436 |  |  |  | 0.04 |  |  |  | 196.00 |  |  |  | 436 |  |  |  | 196.00 |
|  | $235.12 | - | $235.12 |  |  |  | 125 |  |  |  | 0.40 |  |  |  | 235.12 |  |  |  | 125 |  |  |  | 235.12 |
|  | $3.80 | - | $235.12 |  |  |  | 6,355,681 |  |  |  | 8.14 |  |  | $ | 8.22 |  |  |  | 1,770,597 |  |  | $ | 8.67 |
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] |
|  | Number of Shares Exercisable |  |  | Exercise Price |  | Expiration Date
Issued to private placement investors in October 2009 |  |  | 198,864 |  |  | $ | 17.60 |  | 1/7/2015
Issued to private placement investors in July 2011 |  |  | 3,750,000 |  |  | $ | 3.60 |  | 7/1/2016
Other |  |  | 20,000 |  |  | $ | 13.80 |  | 8/1/2015
Total warrants outstanding at December 31, 2013 |  |  | 3,968,864 |  |  | $ | 4.35* |  |
Common Stock Reserved For Future Issuance [Table Text Block] |
|  | No. of Shares |
Issuance upon exercise of outstanding stock options |  |  | 6,355,681 |
Issuance of future grants under stock option plans |  |  | 1,797,694 |
Issuance of future grants under employee stock purchase plan |  |  | 16,651 |
Issuance of common stock related to convertible notes* |  |  | 9,884,342 |
Issuance upon exercise of warrants |  |  | 3,968,864 |
Total |  |  | 22,023,232 |

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- Definition Tabular disclosure of share-based compensation plans that may be presented in a single table for outstanding, vested and expected to vest, and exercisable awards. The information that may be disclosed in this table may include, but is not limited to, number of shares, weighted average exercise price, weighted average remaining contractual life, and aggregate intrinsic value. + References No definition available. + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of warrants or rights issued. Warrants and rights outstanding are derivative securities that give the holder the right to purchase securities (usually equity) from the issuer at a specific price within a certain time frame. Warrants are often included in a new debt issue to entice investors by a higher return potential. The main difference between warrants and call options is that warrants are issued and guaranteed by the company, whereas options are exchange instruments and are not issued by the company. Also, the lifetime of a warrant is often measured in years, while the lifetime of a typical option is measured in months. Disclose the title of issue of securities called for by warrants and rights outstanding, the aggregate amount of securities called for by warrants and rights outstanding, the date from which the warrants or rights are exercisable, and the price at which the warrant or right is exercisable. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(i)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 08 -Paragraph i -Article 4 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 50 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6406099&loc=d3e25284-112666 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 50 -Section S99 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6784392&loc=d3e188667-122775 Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 28 -Article 5 + Details
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