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Note 8 - Stockholders' Equity (Tables)

12 Months Ended

Dec. 31, 2013

Stockholders' Equity Note [Abstract]

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

For the Years Ended December 31,		2013				2012				2011
Expected term (years):
Stock options			6.00				5.51				5.00
Employee Stock Purchase Plan			.49				.49				.50
Risk-free interest rate:
Stock options			1.5	%			0.8	%			1.6	%
Employee Stock Purchase Plan			0.8	%			0.2	%			0.8	%
Volatility:
Stock options			105	%			106	%			106	%
Employee Stock Purchase Plan			212	%			0.8	%			142	%

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

For the Years Ended December 31,		2013				2012				2011
Research and development		$	2,562			$	1,585			$	819
General and adminstrative			8,328				4,147				1,071
Total		$	10,890			$	5,732			$	1,890
Impact on basic and diluted net loss per common share		$	0.67			$	0.47			$	0.31

Schedule of Share-based Compensation, Activity [Table Text Block]

		2013																2012								2011
		Shares				Weighted-  Average  Exercise  Price				Weighted- Average  Remaining  Contractual Term (Years)				Aggregate  Intrinsic  Value as of  December 31, 2013				Shares				Weighted- Average  Exercise  Price				Shares				Weighted- Average  Exercise  Price
Outstanding at beginning of year			4,323,874			$	8.46												2,505,283			$	6.13				160,833			$	29.83
Granted			4,256,971				8.08												1,874,246				11.61				2,403,495				5.19
Exercised			(537,029	)			5.20												-				-				-				-
Expired or Forfeited			(1,688,135	)			9.45												(55,655	)			9.56				(59,045	)			32.53
Outstanding at end of year			6,355,681				8.22				8.14			$	10,704,578				4,323,874				8.46				2,505,283				6.13
Options exercisable at year end			1,770,597				8.67				5.12			$	4,607,452				1,142,099				7.98				337,002				10.68
Options vested or expected to vest			6,292,296				8.22				8.13			$	10,614,670				4,283,344				8.45				2,471,725				6.14
Shares available for future grant at year end			1,797,694																1,018,766								2,213,155
Weighted-average fair value of stock options granted during the year		$					8.08															$	11.61							$	5.19

Schedule of Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding [Table Text Block]

							OPTIONS OUTSTANDING												OPTIONS EXERCISABLE
	Range of Exercise Prices						Number Outstanding				Weighted-Average Remaining Contractual Life (Years)				Weighted-Average Exercise Price				Number Exercisable				Weighted-Average Exercise Price
		$3.80	-	$3.80				5,000				7.99			$	3.80				2,708			$	3.80
		$5.20	-	$5.20				1,072,887				4.02				5.20				997,934				5.20
		$6.40	-	$7.00				386,613				8.60				6.85				80,210				6.66
		$7.20	-	$7.20				3,190,240				9.34				7.20				41,012				7.20
		$7.40	-	$10.60				852,372				9.38				9.89				105,881				10.57
		$11.00	-	$15.00				730,285				7.54				13.15				499,642				12.79
		$15.40	-	$130.40				117,598				6.44				24.14				42,524				39.54
		$139.20	-	$139.20				125				1.08				139.20				125				139.20
		$196.00	-	$196.00				436				0.04				196.00				436				196.00
		$235.12	-	$235.12				125				0.40				235.12				125				235.12
		$3.80	-	$235.12				6,355,681				8.14			$	8.22				1,770,597			$	8.67

Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]

		Number of Shares Exercisable				Exercise Price			Expiration Date
Issued to private placement investors in October 2009			198,864			$	17.60		1/7/2015
Issued to private placement investors in July 2011			3,750,000			$	3.60		7/1/2016
Other			20,000			$	13.80		8/1/2015
Total warrants outstanding at December 31, 2013			3,968,864			$	4.35*

Common Stock Reserved For Future Issuance [Table Text Block]

		No. of Shares
Issuance upon exercise of outstanding stock options			6,355,681
Issuance of future grants under stock option plans			1,797,694
Issuance of future grants under employee stock purchase plan			16,651
Issuance of common stock related to convertible notes*			9,884,342
Issuance upon exercise of warrants			3,968,864
Total			22,023,232

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