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Note 14 - Quarterly Results of Operations (Unaudited) (Tables)
 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Quarterly Financial Information Disclosure [Abstract]    
Schedule of Quarterly Financial Information [Table Text Block]

Year Ended December 31, 2013

 

First Quarter

   

Second Quarter

   

Third Quarter

   

Fourth Quarter

 

Total revenue

  $ -     $ -     $ -     $ -  

Operating expenses

    12,752       15,209       12,664       13,832  

Interest and other expense, net

    (201 )     (204 )     (209 )     (212 )

Net loss

    (12,953 )     (15,413 )     (12,873 )     (14,044 )

Basic and diluted net loss per share:

                               

Net loss

  $ (0.85 )   $ (1.01 )   $ (0.84 )   $ (0.75 )

Year Ended December 31, 2012

 

First Quarter

   

Second Quarter

   

Third Quarter

   

Fourth Quarter

 

Total revenue

  $ -     $ -     $ -     $ -  

Operating expenses

    4,769       4,380       6,054       8,628  

Interest and other expense, net

    (61 )     (146 )     (195 )     (197 )

Loss from continuing operations

    (4,830 )     (4,526 )     (6,249 )     (8,825 )

Discontinued operations

    (91 )     (43 )     128       1,088  

Net loss

    (4,921 )     (4,569 )     (6,121 )     (7,737 )

Basic and diluted net loss per share:

                               

Loss from continuing operations

  $ (0.48 )   $ (0.45 )   $ (0.46 )   $ (0.58 )

Net loss

    (0.49 )     (0.46 )     (0.45 )     (0.51 )