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Note 8 - Stockholders' Equity (Details) - Stock-based Compensation Expense (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Note 8 - Stockholders' Equity (Details) - Stock-based Compensation Expense [Line Items]
Share-based compensation expense	$ 10,890	$ 5,732	$ 1,890
Impact on basic and diluted net loss per common share (in Dollars per share)	$ 0.67	$ 0.47	$ 0.31
Research and Development Expense [Member]
Note 8 - Stockholders' Equity (Details) - Stock-based Compensation Expense [Line Items]
Share-based compensation expense	2,562	1,585	819
General and Administrative Expense [Member]
Note 8 - Stockholders' Equity (Details) - Stock-based Compensation Expense [Line Items]
Share-based compensation expense	$ 8,328	$ 4,147	$ 1,071

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- Definition

Impact on basic and diluted net loss per common share.

+ References

No definition available.

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X

- Definition

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 1

-Subparagraph (b)

-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901



Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section S99

-Paragraph 1

-Subparagraph (SAB TOPIC 14.F)

-URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809



Reference 3: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 2

-Subparagraph (h)(1)(i)

-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901



Reference 4: http://www.xbrl.org/2003/role/presentationRef

-Publisher SEC

-Name Staff Accounting Bulletin (SAB)

-Number Topic 14

-Section F

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