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Condensed Statements of Cash Flows (Unaudited) (USD $)
 3 Months Ended
Mar. 31, 2014
Mar. 31, 2013
Net loss $ (17,538,000) $ (12,953,000)
Adjustments to reconcile net loss to net cash used for operating activities:    
Depreciation and amortization 114,000 70,000
Stock-based compensation expense 2,969,000 1,835,000
Amortization of debt discount 139,000 130,000
Changes in operating assets and liabilities:    
Prepaid expenses and other assets (1,624,000) 157,000
Accounts payable 2,238,000 1,330,000
Accrued expenses (2,011,000) 1,470,000
Net cash used for operating activities (15,713,000) (7,961,000)
Purchases of property and equipment (57,000) (435,000)
Net cash used for investing activities (57,000) (435,000)
Proceeds from warrant exercises   600,000
Proceeds from stock option exercises 958,000 12,000
Net cash provided by financing activities 958,000 612,000
Net decrease in cash (14,812,000) (7,784,000)
Cash at beginning of period 72,287,000 53,506,000
Cash at end of period $ 57,475,000 $ 45,722,000