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Note 5 - Stockholders' Equity (Tables)

6 Months Ended

Jun. 30, 2014

Note 5 - Stockholders' Equity (Tables) [Line Items]

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

		Three Months Ended June 30,								Six Months Ended June 30,
		2014				2013				2014				2013
Research and development		$	446			$	541			$	1,708			$	790
General and administrative			634				1,862				2,341				3,448
Stock-based compensation expense included in operating expenses		$	1,080			$	2,403			$	4,049			$	4,238
Impact on basic and diluted net loss per share		$	0.04			$	0.16			$	0.17			$	0.28

Schedule of Share-based Compensation, Activity [Table Text Block]

										Weighted-
										Average
						Weighted-				Remaining
						Average				Contractual
		Shares				Exercise				Term
		(in thousands)				Price				(Years)
Balance at January 1, 2014			6,356			$	8.22				8.14
Granted			1,239			$	10.06
Exercised			(504	)		$	6.22
Expired and forfeited			(69	)		$	14.70
Balance at June 30, 2014			7,022			$	8.62				8.33

Employee Stock Option [Member]

Note 5 - Stockholders' Equity (Tables) [Line Items]

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

Options:		June 30,
		2014				2013
Risk-free interest rate			2.0	%			0.9	%
Dividend yield			0.0	%			0.0	%
Volatility			104.0	%			104.2	%
Expected life (years)			6				6

Employee Stock Purchase Plan [Member]

Note 5 - Stockholders' Equity (Tables) [Line Items]

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

ESPP:		June 30,
		2014				2013
Risk-free interest rate			0.1	%			0.1	%
Dividend yield			0.0	%			0.0	%
Volatility			58.9	%			88.3	%
Expected life (months)			6				6

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Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

+ References

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 1

-Subparagraph (b)

-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901



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-SubTopic 10

-Section S99

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-Publisher SEC

-Name Staff Accounting Bulletin (SAB)

-Number Topic 14

-Section F



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Tabular disclosure of share-based compensation plans that may be presented in a single table for outstanding, vested and expected to vest, and exercisable awards. The information that may be disclosed in this table may include, but is not limited to, number of shares, weighted average exercise price, weighted average remaining contractual life, and aggregate intrinsic value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 2

-Subparagraph (f)(2)

-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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