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Condensed Statements of Cash Flows (Unaudited) (USD $)
 6 Months Ended
Jun. 30, 2014
Jun. 30, 2013
Net loss $ (36,549,000) $ (28,367,000)
Adjustments to reconcile net loss to net cash used for operating activities:    
Depreciation and amortization 239,000 149,000
Stock-based compensation expense 4,049,000 4,238,000
Amortization of debt discount 281,000 261,000
Changes in operating assets and liabilities:    
Prepaid expenses and other assets 120,000 206,000
Accounts payable 505,000 2,849,000
Accrued clinical liabilities 1,932,000 2,127,000
Accrued payroll and employee-related liabilities (731,000) (110,000)
Other accrued expenses 1,965,000 (135,000)
Net cash used for operating activities (28,189,000) (18,782,000)
Investing activities:    
Purchases of property and equipment (335,000) (541,000)
Net cash used for investing activities (335,000) (541,000)
Financing activities:    
Proceeds from warrant exercises   600,000
Proceeds from purchases under the Employee Stock Purchase Plan 19,000 25,000
Proceeds from stock option exercises 2,308,000 41,000
Net proceeds from sale of common stock and pre-funded warrants 58,922,000  
Net cash provided by financing activities 61,249,000 666,000
Net increase (decrease) in cash 32,725,000 (18,657,000)
Cash at beginning of period 72,287,000 53,506,000
Cash at end of period $ 105,012,000 $ 34,849,000