<SEC-DOCUMENT>0001019056-14-000251.txt : 20140214
<SEC-HEADER>0001019056-14-000251.hdr.sgml : 20140214
<ACCEPTANCE-DATETIME>20140214163242
ACCESSION NUMBER:		0001019056-14-000251
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20140214
DATE AS OF CHANGE:		20140214
GROUP MEMBERS:		JOSEPH EDELMAN
GROUP MEMBERS:		PERCEPTIVE ADV

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HERON THERAPEUTICS, INC. /DE/
		CENTRAL INDEX KEY:			0000818033
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				942875566
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-39444
		FILM NUMBER:		14617405

	BUSINESS ADDRESS:	
		STREET 1:		123 SAGINAW DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063
		BUSINESS PHONE:		6503662626

	MAIL ADDRESS:	
		STREET 1:		123 SAGINAW DRIVE
		STREET 2:		123 SAGINAW DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AP PHARMA INC /DE/
		DATE OF NAME CHANGE:	20010511

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADVANCED POLYMER SYSTEMS INC /DE/
		DATE OF NAME CHANGE:	19920703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PERCEPTIVE ADVISORS LLC
		CENTRAL INDEX KEY:			0001224962
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		499 PARK AVENUE, 25TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		646-205-5340

	MAIL ADDRESS:	
		STREET 1:		499 PARK AVENUE, 25TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>heron_13ga2.htm
<DESCRIPTION>SCHEDULE 13G/A
<TEXT>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font: normal 14pt Times New Roman, Times, Serif">UNITED
STATES</FONT><BR>
<FONT STYLE="font-size: 14pt; font-weight: normal">SECURITIES AND EXCHANGE COMMISSION</FONT><BR>
<FONT STYLE="font-size: 12pt; font-weight: normal">Washington, D.C. 20549</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 10pt 0 0; text-align: center"><FONT STYLE="font: 18pt Times New Roman, Times, Serif"><B>SCHEDULE
13G/A</B></FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font: 12pt Times New Roman, Times, Serif">(Amendment
No. 2)</FONT><BR></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 10pt 0 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font: 12pt Times New Roman, Times, Serif"><B>Under
the Securities Exchange Act of 1934</B></FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 10pt 0 0; text-align: center"><FONT STYLE="font: 24pt Times New Roman, Times, Serif"><B>Heron
Therapeutics, Inc. (f/k/a A.P. Pharma, Inc.)</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"></FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(Name
of Issuer)</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Common
Stock</B></FONT></P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(Title
of Class of Securities)</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>00202J203</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(CUSIP
Number)</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>December
31, 2013</B></FONT></P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(Date
of Event Which Requires Filing of this Statement)</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check the
appropriate box to designate the rule pursuant to which this Schedule is filed:</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 5%; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings">x</FONT></TD>
    <TD STYLE="width: 95%; padding-right: 3pt; padding-left: 3pt; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Rule
    13d-1(b)</FONT></TD></TR>
<TR STYLE="font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Rule
    13d-1(c)</FONT></TD></TR>
<TR STYLE="font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Rule
    13d-1(d)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">*The
remainder of this cover page shall be filled out for a reporting person&rsquo;s initial filing on this form with respect to the
subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided
in a prior cover page.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">The
information required in the remainder of this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section
18 of the Securities Exchange Act of 1934 (&ldquo;Act&rdquo;) or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the Notes).</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Persons
who are to respond to the collection of information contained in this form are not required to respond unless the form displays
a currently valid OMB control number.</B></FONT></P>

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    <TD STYLE="width: 32%; border: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-top: 0; padding-bottom: 0; text-align: left; vertical-align: middle; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">C<FONT STYLE="font-family: Times New Roman, Times, Serif">USIP
    No. 00202J203</font></FONT></TD>
    <TD STYLE="width: 35%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: bold 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; vertical-align: middle"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 33%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-top: 12pt; padding-bottom: 12pt; text-align: center; vertical-align: middle"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Page
    2 of 7 Pages</FONT></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 6%; text-indent: -0.25in">&nbsp;</TD>
    <TD STYLE="width: 9%; padding-top: 6pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding-top: 6pt; padding-left: 0.25in">&nbsp;</TD>
    <TD STYLE="width: 41%; padding-top: 6pt; padding-left: 0.25in">&nbsp;</TD>
    <TD STYLE="width: 16%; padding-top: 6pt; padding-left: 0.25in">&nbsp;</TD>
    <TD STYLE="width: 10%; padding-top: 6pt; padding-left: 0.25in">&nbsp;</TD>
    <TD STYLE="width: 13%; padding-top: 6pt; padding-left: 0.25in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; border-top: black 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold">1.</TD>
    <TD COLSPAN="6" STYLE="border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><FONT STYLE="font-variant: small-caps">names of reporting
        persons</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">i.r.s. identification no.
        of above persons (entities only)</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps"><B>Perceptive Advisors LLC</B></FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-left: black 1pt solid; border-bottom: black 1pt solid; border-right: black 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold">2.</TD>
    <TD COLSPAN="5" STYLE="border-bottom: Black 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-variant: small-caps">check the appropriate box if a group*</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-variant: small-caps">(</FONT>a)
        <FONT STYLE="font-family: Wingdings">o</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-variant: small-caps">(</FONT>b)
        <FONT STYLE="font-family: Wingdings">o</FONT></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold">3.</TD>
    <TD COLSPAN="6" STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><FONT STYLE="font-variant: small-caps">sec use only</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold">4.</TD>
    <TD COLSPAN="6" STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><FONT STYLE="font-variant: small-caps">citizenship or place
        of organization</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><FONT STYLE="font-variant: small-caps"><B>Delaware, United
        States of America</B></FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">&nbsp;</P></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; font-variant: small-caps; font-weight: bold; text-align: center">number of<BR> shares</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; font-weight: bold; padding-left: 5.4pt">5.</TD>
    <TD STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-right: 5.4pt; padding-left: 5.4pt; font-variant: small-caps">sole voting power</TD>
    <TD COLSPAN="3" STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-variant: small-caps; font-weight: bold; text-align: right; padding-right: 5.4pt">0</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; font-variant: small-caps; font-weight: bold; text-align: center">beneficially<BR> owned by</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; font-weight: bold; padding-left: 5.4pt">6.</TD>
    <TD STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-right: 5.4pt; padding-left: 5.4pt; font-variant: small-caps">shared voting power</TD>
    <TD COLSPAN="3" STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-variant: small-caps; font-weight: bold; text-align: right; padding-right: 5.4pt">35,248,555</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; font-variant: small-caps; font-weight: bold; text-align: center">each<BR> reporting</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; font-weight: bold; padding-left: 5.4pt">7.</TD>
    <TD STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; padding: 6pt 5.4pt; border-right: windowtext 1pt solid; font-variant: small-caps">sole dispositive power</TD>
    <TD COLSPAN="3" STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-variant: small-caps; font-weight: bold; text-align: right; padding-right: 5.4pt">0</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; font-variant: small-caps; font-weight: bold; text-align: center">person with:</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold; padding-bottom: 6pt">8.</TD>
    <TD STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-bottom: 6pt; padding-left: 5.4pt; font-variant: small-caps">shared dispostive power</TD>
    <TD COLSPAN="3" STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt; font-variant: small-caps; font-weight: bold; text-align: right"><P STYLE="margin: 0">35,248,555</P>


</TD></TR>
<TR>
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold; padding-bottom: 6pt">9.</TD>
    <TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-bottom: 6pt; padding-left: 5.4pt; font-variant: small-caps">aggregate amount beneficially owned by each reporting person</TD>
    <TD COLSPAN="2" STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-right: 5.4pt; padding-bottom: 6pt; font-variant: small-caps; font-weight: bold; text-align: right">35,248,555</TD></TR>
<TR>
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold; padding-bottom: 6pt">10.</TD>
    <TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: Black 1pt solid; padding-top: 6pt; padding-bottom: 6pt; padding-left: 5.4pt; font-variant: small-caps"><FONT STYLE="font-variant: small-caps">check
box if the aggregate amount in row (9) excludes certain shares (See Instructions)</FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: center; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; padding-left: 1.25in; vertical-align: middle"><FONT STYLE="font-family: Wingdings">o</FONT>&nbsp;</TD></TR>
<TR>
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold; padding-bottom: 6pt">11.</TD>
    <TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-bottom: 6pt; padding-left: 5.4pt; font-variant: small-caps">percent of class represented by amount in row (9)</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-right: 5.4pt; padding-bottom: 6pt; font-variant: small-caps; font-weight: bold; text-align: right">7.47%</TD></TR>
<TR>
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold; padding-bottom: 6pt">12.</TD>
    <TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-bottom: 6pt; padding-left: 5.4pt; font-variant: small-caps">type of reporting person (See Instructions)</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-bottom: 6pt; padding-left: 1.25in; font-variant: small-caps; font-weight: bold">IA</TD></TR>
</TABLE>

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    <TD STYLE="width: 32%; border: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-top: 0; padding-bottom: 0; text-align: left; vertical-align: middle; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">C<FONT STYLE="font-family: Times New Roman, Times, Serif">USIP
    No. 00202J203</FONT></FONT></TD>
    <TD STYLE="width: 35%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: bold 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; vertical-align: middle"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 33%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-top: 12pt; padding-bottom: 12pt; text-align: center; vertical-align: middle"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Page
    3 of 7 Pages</FONT></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 6%; text-indent: -0.25in">&nbsp;</TD>
    <TD STYLE="width: 9%; padding-top: 6pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding-top: 6pt; padding-left: 0.25in">&nbsp;</TD>
    <TD STYLE="width: 41%; padding-top: 6pt; padding-left: 0.25in">&nbsp;</TD>
    <TD STYLE="width: 16%; padding-top: 6pt; padding-left: 0.25in">&nbsp;</TD>
    <TD STYLE="width: 10%; padding-top: 6pt; padding-left: 0.25in">&nbsp;</TD>
    <TD STYLE="width: 13%; padding-top: 6pt; padding-left: 0.25in">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; border-top: black 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold">13.</TD>
    <TD COLSPAN="6" STYLE="border-top: black 1pt solid; border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><FONT STYLE="font-variant: small-caps">names of reporting
        persons</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">i.r.s. identification no.
        of above persons (entities only)</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><FONT STYLE="font-variant: small-caps"><B>Joseph  Edelman</B></FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-left: black 1pt solid; border-bottom: black 1pt solid; border-right: black 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold">14.</TD>
    <TD COLSPAN="5" STYLE="border-bottom: Black 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-variant: small-caps">check the appropriate box if a group*</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-variant: small-caps">(</FONT>a)
        <FONT STYLE="font-family: Wingdings">o</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"><FONT STYLE="font-variant: small-caps">(</FONT>b)
        <FONT STYLE="font-family: Wingdings">o</FONT></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold">15.</TD>
    <TD COLSPAN="6" STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><FONT STYLE="font-variant: small-caps">sec use only</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold">16.</TD>
    <TD COLSPAN="6" STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><FONT STYLE="font-variant: small-caps">citizenship or place
        of organization</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><FONT STYLE="font-variant: small-caps"><B>United
        States of America</B></FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">&nbsp;</P></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; font-variant: small-caps; font-weight: bold; text-align: center">number of<BR> shares</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; font-weight: bold; padding-left: 5.4pt">17.</TD>
    <TD STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-right: 5.4pt; padding-left: 5.4pt; font-variant: small-caps">sole voting power</TD>
    <TD COLSPAN="3" STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-variant: small-caps; font-weight: bold; text-align: right; padding-right: 5.4pt">0</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; font-variant: small-caps; font-weight: bold; text-align: center">beneficially<BR> owned by</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; font-weight: bold; padding-left: 5.4pt">18.</TD>
    <TD STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-right: 5.4pt; padding-left: 5.4pt; font-variant: small-caps">shared voting power</TD>
    <TD COLSPAN="3" STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-variant: small-caps; font-weight: bold; text-align: right; padding-right: 5.4pt">35,248,555</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; font-variant: small-caps; font-weight: bold; text-align: center">each<BR> reporting</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; font-weight: bold; padding-left: 5.4pt">19.</TD>
    <TD STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; padding: 6pt 5.4pt; border-right: windowtext 1pt solid; font-variant: small-caps">sole dispositive power</TD>
    <TD COLSPAN="3" STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-variant: small-caps; font-weight: bold; text-align: right; padding-right: 5.4pt">0</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; font-variant: small-caps; font-weight: bold; text-align: center">person with:</TD>
    <TD STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold; padding-bottom: 6pt">20.</TD>
    <TD STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-bottom: 6pt; padding-left: 5.4pt; font-variant: small-caps">shared dispostive power</TD>
    <TD COLSPAN="3" STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-right: 5.4pt; padding-left: 5.4pt; font-variant: small-caps; font-weight: bold; text-align: right">35,248,555</TD></TR>
<TR>
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold; padding-bottom: 6pt">21.</TD>
    <TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-bottom: 6pt; padding-left: 5.4pt; font-variant: small-caps">aggregate amount beneficially owned by each reporting person</TD>
    <TD COLSPAN="2" STYLE="border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-right: 5.4pt; padding-bottom: 6pt; font-variant: small-caps; font-weight: bold; text-align: right">35,248,555</TD></TR>
<TR>
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold; padding-bottom: 6pt">22.</TD>
    <TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: Black 1pt solid; padding-top: 6pt; padding-bottom: 6pt; padding-left: 5.4pt; font-variant: small-caps"><FONT STYLE="font-variant: small-caps">check
box if the aggregate amount in row (9) excludes certain shares (See Instructions)</FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: center; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; padding-left: 1.25in; vertical-align: middle"><FONT STYLE="font-family: Wingdings">o</FONT>&nbsp;</TD></TR>
<TR>
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold; padding-bottom: 6pt">23.</TD>
    <TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-bottom: 6pt; padding-left: 5.4pt; font-variant: small-caps">percent of class represented by amount in row (9)</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-right: 5.4pt; padding-bottom: 6pt; font-variant: small-caps; font-weight: bold; text-align: right">7.47%</TD></TR>
<TR>
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; padding-top: 6pt; padding-left: 5.4pt; font-weight: bold; padding-bottom: 6pt">24.</TD>
    <TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-bottom: 6pt; padding-left: 5.4pt; font-variant: small-caps">type of reporting person (See Instructions)</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; border-bottom: windowtext 1pt solid; border-right: windowtext 1pt solid; padding-top: 6pt; padding-bottom: 6pt; padding-left: 1.25in; font-variant: small-caps; font-weight: bold">IN</TD></TR>
</TABLE>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 32%; border: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-top: 0; padding-bottom: 0; text-align: left; vertical-align: middle; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">C<FONT STYLE="font-family: Times New Roman, Times, Serif">USIP
    No. 00202J203</font></font></TD>
    <TD STYLE="width: 35%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: bold 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; vertical-align: middle"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 33%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-top: 12pt; padding-bottom: 12pt; text-align: center; vertical-align: middle"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Page
    4 of 7 Pages</FONT></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 6%; padding-right: 3pt; padding-left: 3pt; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="width: 1%; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="width: 4%">&nbsp;</TD>
    <TD STYLE="width: 25%">&nbsp;</TD>
    <TD STYLE="width: 15%; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="width: 4%">&nbsp;</TD>
    <TD STYLE="width: 45%">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="7" STYLE="padding-right: 3pt; padding-left: 3pt; font-weight: bold">Item 1.</TD></TR>
<TR>
    <TD COLSPAN="7" STYLE="padding-right: 3pt; padding-left: 3pt; font-weight: bold">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: center; vertical-align: top">&nbsp;(a)</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt">Name of Issuer:</TD>
    <TD COLSPAN="3" STYLE="font-weight: bold">Heron Therapeutics, Inc. (f/k/a A.P. Pharma, Inc.)</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-weight: bold">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: center; vertical-align: top">&nbsp;(b)</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: left; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: left; vertical-align: top">Address of Issuer&rsquo;s Principal Executive Offices:</TD>
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: left; vertical-align: top">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>123 Saginaw Drive</B><BR>
<B>Redwood City, CA 94063 </B></P></TD></TR>
<TR>
    <TD COLSPAN="7" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="7" STYLE="padding-right: 3pt; padding-left: 3pt; font-weight: bold">Item 2.</TD></TR>
<TR>
    <TD COLSPAN="7" STYLE="padding-right: 3pt; padding-left: 3pt; font-weight: bold">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: center; vertical-align: top">&nbsp;(a)</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: left; vertical-align: top">Name of Person Filing:</TD>
    <TD COLSPAN="3" STYLE="font-weight: bold; padding-left: 4pt; text-align: justify">This Schedule 13G/A (the &ldquo;Schedule&rdquo;) is being filed with respect to shares of Common Stock (as
defined below) of <B>Heron Therapeutics, Inc.</B><FONT STYLE="font: normal 10pt Times New Roman, Times, Serif"> (</FONT><B>the &ldquo;Issuer&rdquo;)
which are beneficially owned by Perceptive Advisors LLC and Joseph Edelman (together, the &ldquo;Reporting Persons&rdquo;). See
Item 4 below.</B></TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: center; vertical-align: top">&nbsp;(b)</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: left; vertical-align: top">Address of Principal Business Office or, if none, Residence:</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="font-weight: bold"><FONT STYLE="font-size: 10pt"><B>499 Park Avenue, 25<SUP>th </SUP>Floor </B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>New York, NY 10022</B></FONT></TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: center; vertical-align: top">&nbsp;(c)&nbsp;</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: left; vertical-align: top">Citizenship:</TD>
    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: justify; padding-left: 4pt">Perceptive Advisors LLC is a Delaware limited liability company and Joseph Edelman is a United States Citizen.</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 3pt; padding-left: 3pt; font-weight: bold; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: center; vertical-align: top">&nbsp;(d)&nbsp;</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt">Title of Class of Securities:</TD>
    <TD COLSPAN="3" STYLE="font-weight: bold; padding-left: 4pt">Common Stock</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 3pt; padding-left: 3pt; font-weight: bold">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: center; vertical-align: top">&nbsp;(e)&nbsp;</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt">CUSIP Number:</TD>
    <TD COLSPAN="3" STYLE="font-weight: bold; padding-left: 4pt">00202J203</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 3pt; padding-left: 3pt; font-weight: bold">&nbsp;</TD></TR>
<TR>
    <TD NOWRAP COLSPAN="2" STYLE="vertical-align: top; padding: 3pt; font-weight: bold">Item 3.</TD>
    <TD COLSPAN="5" STYLE="padding-top: 3pt; padding-bottom: 3pt; font-weight: bold; text-align: justify">If this statement is filed pursuant to &sect;&sect;240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="font-weight: bold">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">(a)</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD>&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify">Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">(b)</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD>&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify">Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">(c)</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD>&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt">Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">(d)</TD>
    <TD STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify">Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8).</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">(e)</TD>
    <TD STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;<FONT STYLE="font-family: Wingdings">x</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt">An investment adviser in accordance with &sect;240.13d-1(b)(1)(ii)(E);</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">(f)</TD>
    <TD STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt">An employee benefit plan or endowment fund in accordance with &sect;240.13d-1(b)(1)(ii)(F);</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">(g)</TD>
    <TD STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt">A parent holding company or control person in accordance with &sect; 240.13d-1(b)(1)(ii)(G);</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">(h)</TD>
    <TD STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify">A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">(i)</TD>
    <TD STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify">A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">(j)</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD>&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 3pt; padding-left: 3pt">Group, in accordance with &sect;240.13d-1(b)(1)(ii)(J).</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

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    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 2pt solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <!-- Field: /Page -->
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 32%; border: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-top: 0; padding-bottom: 0; text-align: left; vertical-align: middle; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">C<FONT STYLE="font-family: Times New Roman, Times, Serif">USIP
    No. 00202J203</FONT></FONT></TD>
    <TD STYLE="width: 35%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: bold 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; vertical-align: middle"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 33%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-top: 12pt; padding-bottom: 12pt; text-align: center; vertical-align: middle"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Page
    5 of 7 Pages</FONT></TD></TR>
</TABLE>


<P STYLE="margin: 0; text-indent: 0.5in"></P>

<P STYLE="margin: 0; text-indent: 0.5in; text-align: justify"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 10pt; margin-bottom: 0pt; width: 100%">
<TR>
    <TD STYLE="width: 10%; font: bold 10pt Times New Roman, Times, Serif; text-align: justify">Item 4.</TD>
    <TD STYLE="width: 90%; font: bold 10pt Times New Roman, Times, Serif; text-align: justify">Ownership.</TD></TR>
</TABLE>


<P STYLE="margin: 0; text-indent: 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="margin: 0; text-indent: 0.5in; text-align: justify">Provide the following information regarding the aggregate number and percentage of the class of securities
of the issuer identified in Item 1.</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="text-align: justify; width: 10%">&nbsp;</TD>
    <TD STYLE="width: 10%">&nbsp;</TD>
    <TD STYLE="width: 20%">&nbsp;</TD>
    <TD STYLE="width: 17%; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 43%; text-align: justify">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: left; text-indent: 19.5pt; vertical-align: top">(a)</TD>
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: left; vertical-align: top">Amount beneficially owned:</TD>
    <TD COLSPAN="2" STYLE="padding-right: 0; padding-bottom: 0; padding-left: 0; text-align: justify">The Reporting Persons beneficially own 35,248,555<FONT STYLE="font-variant: small-caps"> </FONT>shares of Common
Stock held by a private investment fund (the &ldquo;Fund&rdquo;) to which Perceptive Advisors LLC serves as the investment manager.
Mr. Edelman is the managing member of Perceptive Advisors LLC.</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify; text-indent: 19.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 0; padding-bottom: 0; padding-left: 0">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: left; text-indent: 19.5pt; vertical-align: top">(b)</TD>
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: left; vertical-align: top">Percent of class:</TD>
    <TD COLSPAN="2" STYLE="padding-top: 0; padding-bottom: 0; text-align: justify">The beneficial ownership of 7.47% is based on
    the 471,745,560 outstanding shares of Common Stock of the Issuer as disclosed on the Issuer&rsquo;s Form 8-K filed with the
    SEC     on     January     17, 2014.</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify; text-indent: 19.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-top: 0; padding-bottom: 0">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify; text-indent: 19.5pt">(c)</TD>
    <TD COLSPAN="3" STYLE="padding-right: 0; padding-left: 0; text-align: justify">Number of shares as to which the person has:</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">
                </TD></TR>
<TR>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify; text-indent: 19.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding-right: 3pt; padding-left: 3pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">(i)</TD>
    <TD COLSPAN="2">Sole power to vote or to direct the vote:</TD>
    <TD STYLE="vertical-align: top; font-variant: small-caps; text-align: right">0</TD></TR>
<TR>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD>
    <TD STYLE="vertical-align: top; font-variant: small-caps; text-align: right">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">(ii)</TD>
    <TD COLSPAN="2">Shared power to vote or to direct the vote:</TD>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;<FONT STYLE="font-variant: small-caps">35,248,555</FONT></TD></TR>
<TR>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">(iii)</TD>
    <TD COLSPAN="2">Sole power to dispose or to direct the disposition of:</TD>
    <TD STYLE="vertical-align: top; text-align: right">0</TD></TR>
<TR>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: center">(iv)</TD>
    <TD COLSPAN="2">Shared power to dispose or to direct the disposition of:</TD>
    <TD STYLE="vertical-align: top; text-align: right">35,248,555</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 10%; text-align: left"><B>Item&nbsp;5.</B></TD><TD STYLE="width: 90%"><B>Ownership of Five Percent or Less of
                                                                 a Class.</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; margin-left: 0.75in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">If this statement is being filed to report
the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the
class of securities, check the following: <FONT STYLE="font-family: Wingdings">o</FONT><B>.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 2.6pt"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 10pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 10%; text-align: left"><B>Item&nbsp;6.</B></TD><TD STYLE="width: 90%"><B>Ownership of More Than Five Percent
on Behalf of Another Person.</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 10pt 0 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0pt; text-align: justify">The Fund described in Item 4 has the right
to receive or the power to direct the receipt of dividends from, or the proceeds from, the sale of the securities held in its account.
Filing of this statement by the Reporting Persons shall not be deemed an admission that they beneficially own the securities reported
herein. The Reporting Persons expressly disclaim beneficial ownership of all securities reported herein.</P>


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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 32%; border: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-top: 0; padding-bottom: 0; text-align: left; vertical-align: middle; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">C<FONT STYLE="font-family: Times New Roman, Times, Serif">USIP
    No. 00202J203</FONT></font></TD>
    <TD STYLE="width: 35%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: bold 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; vertical-align: middle"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 33%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-top: 12pt; padding-bottom: 12pt; text-align: center; vertical-align: middle"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Page
    6 of 7 Pages</FONT></TD></TR>
</TABLE>


<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%">                                                                                                                                        <TR STYLE="vertical-align: top">
<TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="width: 10%; text-align: left"><B>Item 7.</B></TD><TD STYLE="width: 90%; text-align: justify"><B> Identification and Classification of the Subsidiary
which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 10pt 0 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-right: 0; margin-bottom: 0">Not applicable.&#9;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">                                                                                                                         <TR STYLE="vertical-align: top">
<TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="width: 10%; text-align: left"><B>Item</B> <B>8.</B></TD><TD STYLE="width: 90%"><B>Identification and Classification of Members of the
Group.</B></TD>
</TR>               <TR STYLE="vertical-align: top">
<TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD COLSPAN="2" STYLE="text-align: left">Not applicable.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left"><B>Item 9.</B></TD><TD><B>Notice of Dissolution of Group.</B></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD COLSPAN="2" STYLE="text-align: left">Not applicable.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left"><B>Item 10.</B></TD><TD><B>Certification.</B></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left">&nbsp;</TD><TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">The
                                                                                                            following certification
                                                                                                            shall be included
                                                                                                            if the statement is
                                                                                                            filed pursuant to
                                                                                                            &sect;240.13d-1(b):</font></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left; vertical-align: top">(a)</TD><TD STYLE="padding-left: 0.25in; text-align: justify">By
        signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and
        are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect
        of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection
        with or as a participant in any transaction having that purpose or effect. <FONT STYLE="font-family: Wingdings">x</FONT></TD></TR>
</TABLE>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 32%; border: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-top: 0; padding-bottom: 0; text-align: left; vertical-align: middle; padding-left: 5.4pt"><FONT STYLE="font-size: 10pt">C<FONT STYLE="font-family: Times New Roman, Times, Serif">USIP
    No. 00202J203</font></font></TD>
    <TD STYLE="width: 35%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: bold 10pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center; vertical-align: middle"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 33%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; font: 10pt Times New Roman, Times, Serif; padding-top: 12pt; padding-bottom: 12pt; text-align: center; vertical-align: middle"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Page
    7 of 7 Pages</FONT></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 10pt 0 0; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>SIGNATURE</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">After
reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true,
complete and correct.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>



<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 50%"><U>February 14, 2014</U></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Date</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>PERCEPTIVE ADVISORS LLC</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><U>/s/ Joseph Edelman</U></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Signature</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><U>Joseph Edelman/Managing Member</U></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Name/Title</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><U>February 14, 2014</U></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Date</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><U>/s/ Joseph Edelman</U></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Signature</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><U>Joseph Edelman</U></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Name/Title</TD></TR>
</TABLE>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">The
original statement shall be signed by each person on whose behalf the statement is filed or his authorized representative. If
the statement is signed on behalf of a person by his authorized representative other than an executive officer or general partner
of the filing person, evidence of the representative&rsquo;s authority to sign on behalf of such person shall be filed with the
statement, provided, however, that a power of attorney for this purpose which is already on file with the Commission may be incorporated
by reference. The name and any title of each person who signs the statement shall be typed or printed beneath his signature.</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><I>NOTE</I>:
Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. <I>See
</I>&sect;240.13d-7 for other parties for whom copies are to be sent.</FONT></P>

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    <TD STYLE="width: 90%; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Intentional
    misstatements or omissions of fact constitute Federal criminal violations (See 18 U.S.C. 1001)</B></FONT></TD></TR>
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