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Note 7 - Stockholders' Equity (Tables) | 12 Months Ended
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Dec. 31, 2014
Stockholders' Equity Note [Abstract] |
Common Stock Reserved for Future Issuance [Table Text Block] |
|  | Number of Shares |
Stock options outstanding |  |  | 7,918,004 |
Stock options available for grant |  |  | 1,333,212 |
Employee stock purchase plan |  |  | 29,893 |
Warrants outstanding |  |  | 4,108,147 |
Common stock underlying Convertible Notes outstanding |  |  | 6,676,845 |
Total shares reserved for future issuance |  |  | 20,066,101 |
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] |
|  | Number of Shares Outstanding |  |  | Exercise Price |  | Expiration Date
Issued to private placement investors in October 2009 |  |  | 198,860 |  |  | $ | 17.60 |  | 01/07/2015
Issued to private placement investors in July 2011 |  |  | 3,289,287 |  |  | $ | 3.60 |  | 07/01/2016
Issued in a public offering in June 2014 |  |  | 600,000 |  |  | $ | 0.01 |  | 06/30/2021
Other |  |  | 20,000 |  |  | $ | 13.80 |  | 08/01/2015
Total warrants outstanding |  |  | 4,108,147 |  |  |  |  |  |
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] |
|  | Outstanding Options |
|  |  |  |  |  | Weighted- |
|  |  |  |  |  | Average |
|  | Number of |  |  | Exercise |
|  | Shares |  |  | Price |
Balance at December 31, 2011 |  |  | 2,505,283 |  |  | $ | 6.13 |
Granted |  |  | 1,874,246 |  |  |  | 11.61 |
Exercised |  |  | — |  |  |  | — |
Cancelled |  |  | (55,655 | ) |  |  | 9.56 |
Balance at December 31, 2012 |  |  | 4,323,874 |  |  |  | 8.46 |
Granted |  |  | 4,256,971 |  |  |  | 8.08 |
Exercised |  |  | (537,029 | ) |  |  | 5.20 |
Cancelled |  |  | (1,688,135 | ) |  |  | 9.45 |
Balance at December 31, 2013 |  |  | 6,355,681 |  |  |  | 8.22 |
Granted |  |  | 3,181,001 |  |  |  | 9.40 |
Exercised |  |  | (756,593 | ) |  |  | 6.34 |
Cancelled |  |  | (862,085 | ) |  |  | 9.88 |
Balance at December 31, 2014 |  |  | 7,918,004 |  |  | $ | 8.69 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding and Exercisable [Table Text Block] |
|  | Years Ended December 31, |
|  | 2014 |  |  | 2013 |  |  | 2012 |
|  |  |  |  |  | Weighted- |  |  |  |  |  |  | Weighted- |  |  |  |  |  |  | Weighted- |
|  |  |  |  |  | Average |  |  |  |  |  |  | Average |  |  |  |  |  |  | Average |
|  |  |  |  |  | Exercise |  |  |  |  |  |  | Exercise |  |  |  |  |  |  | Exercise |
|  | Options |  |  | Price |  |  | Options |  |  | Price |  |  | Options |  |  | Price |
Exercisable at end of year |  |  | 2,237,901 |  |  | $ | 9.01 |  |  |  | 1,770,597 |  |  | $ | 8.67 |  |  |  | 1,142,099 |  |  | $ | 7.98 |
Options vested or expected to vest |  |  | 7,841,074 |  |  | $ | 8.69 |  |  |  | 6,292,296 |  |  | $ | 8.22 |  |  |  | 4,283,344 |  |  | $ | 8.45 |
Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block] |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Weighted- |
|  |  |  |  |  | Weighted- |  |  |  |  |  |  |  |  |  |  | Average |
|  |  |  |  |  | Average |  |  | Weighted- |  |  |  |  |  |  | Exercise |
|  |  |  |  |  | Remaining |  |  | Average |  |  |  |  |  |  | Price of |
| Options |  | Range of |  | Contractual |  |  | Exercise |  |  | Options |  |  | Options |
| Outstanding |  | Exercise Prices |  | Life (in years) |  |  | Price |  |  | Exercisable |  |  | Exercisable |
|  | 953,090 |  | $3.80 – $7.00 |  |  | 5.92 |  |  | $ | 5.78 |  |  |  | 662,840 |  |  | $ | 5.34 |
|  | 2,511,808 |  | $7.20 |  |  | 8.01 |  |  |  | 7.20 |  |  |  | 531,578 |  |  |  | 7.20 |
|  | 2,428,458 |  | $7.61 – $9.05 |  |  | 9.12 |  |  |  | 8.87 |  |  |  | 204,669 |  |  |  | 8.95 |
|  | 1,991,338 |  | $9.20 – $15.40 |  |  | 7.42 |  |  |  | 11.27 |  |  |  | 805,504 |  |  |  | 12.09 |
|  | 33,310 |  | $15.41 – $139.20 |  |  | 1.05 |  |  |  | 36.97 |  |  |  | 33,310 |  |  |  | 36.97 |
|  | 7,918,004 |  | $3.80 – $139.20 |  |  | 7.92 |  |  |  | 8.69 |  |  |  | 2,237,901 |  |  |  | 9.01 |
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] |
|  | December 31, |
|  | 2014 |  |  | 2013 |  |  | 2012 |
Research and development |  | $ | 3,329 |  |  | $ | 2,562 |  |  | $ | 1,617 |
General and administrative |  |  | 4,738 |  |  |  | 8,328 |  |  |  | 4,115 |
Stock-based compensation expense included in operating expenses |  | $ | 8,067 |  |  | $ | 10,890 |  |  | $ | 5,732 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | December 31, |
|  | 2014 |  |  | 2013 |  |  | 2012 |
Risk-free interest rate |  |  | 1.9 | % |  |  | 1.1 | % |  |  | 0.8 | %
Dividend yield |  |  | — | % |  |  | — | % |  |  | — | %
Volatility |  |  | 99.0 | % |  |  | 104.2 | % |  |  | 106.2 | %
Expected life (years) |  |  | 6.0 |  |  |  | 6.0 |  |  |  | 5.5 |
|  | December 31, |
|  | 2014 |  |  | 2013 |  |  | 2012 |
Risk-free interest rate |  |  | 0.1 | % |  |  | 0.1 | % |  |  | 0.2 | %
Dividend yield |  |  | — | % |  |  | — | % |  |  | — | %
Volatility |  |  | 53.8 | % |  |  | 76.0 | % |  |  | 77.9 | %
Expected life (years) |  |  | 0.5 |  |  |  | 0.5 |  |  |  | 0.5 |

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