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Note 8 - Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2014
Income Tax Disclosure [Abstract] |
Schedule of Deferred Tax Assets and Liabilities [Table Text Block] |
|  | December 31, |
|  | 2014 |  |  | 2013 |
Deferred tax assets: |  |  |  |  |  |  |  |
Net operating loss carryforward |  | $ | 59,513 |  |  | $ | 31,834 |
Research and development credits |  |  | 7,667 |  |  |  | 4,792 |
Stock-based compensation |  |  | 5,128 |  |  |  | 4,124 |
Other, net |  |  | 964 |  |  |  | 487 |
Total deferred tax assets |  |  | 73,272 |  |  |  | 41,237 |
Valuation allowance for net deferred tax assets |  |  | (73,272 | ) |  |  | (41,237 | )
Net deferred taxes |  | $ | — |  |  | $ | — |
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] |
|  | December 31, |
|  | 2014 |  |  | 2013 |  |  | 2012 |
Statutory federal income tax rate of 34% |  | $ | (25,965 | ) |  | $ | (18,796 | ) |  | $ | (7,937 | )
Stock-based compensation expense |  |  | 551 |  |  |  | 513 |  |  |  | 176 |
NOL not benefitted |  |  | 25,085 |  |  |  | 17,983 |  |  |  | 7,551 |
Other, net |  |  | 329 |  |  |  | 300 |  |  |  | 210 |
Provision for taxes |  | $ | — |  |  | $ | — |  |  | $ | — |
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block] |
|  | December 31, |
|  | 2014 |  |  | 2013 |
|  | (in thousands) |
Unrecognized tax benefit: |  |  |  |  |  |  |  |
Beginning of period |  | $ | 120 |  |  | $ | 120 |
Current year changes |  |  | — |  |  |  | — |
Prior year changes |  |  | — |  |  |  | — |
End of Period |  | $ | 120 |  |  | $ | 120 |

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- Definition Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 9 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32639-109319 + Details
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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32537-109319 + Details
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- Definition Tabular disclosure of the change in unrecognized tax benefits. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 55 -Paragraph 217 -URI http://asc.fasb.org/extlink&oid=32707879&loc=d3e36027-109320 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 15A -URI http://asc.fasb.org/extlink&oid=6907707&loc=SL6600010-109319 + Details
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