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Note 7 - Stockholders' Equity (Tables)

12 Months Ended

Dec. 31, 2014

Stockholders' Equity Note [Abstract]

Common Stock Reserved for Future Issuance [Table Text Block]

		Number of Shares
Stock options outstanding			7,918,004
Stock options available for grant			1,333,212
Employee stock purchase plan			29,893
Warrants outstanding			4,108,147
Common stock underlying Convertible Notes outstanding			6,676,845
Total shares reserved for future issuance			20,066,101

Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]

		Number of Shares Outstanding				Exercise Price			Expiration Date
Issued to private placement investors in October 2009			198,860			$	17.60		01/07/2015
Issued to private placement investors in July 2011			3,289,287			$	3.60		07/01/2016
Issued in a public offering in June 2014			600,000			$	0.01		06/30/2021
Other			20,000			$	13.80		08/01/2015
Total warrants outstanding			4,108,147

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

		Outstanding Options
						Weighted-
						Average
		Number of				Exercise
		Shares				Price
Balance at December 31, 2011			2,505,283			$	6.13
Granted			1,874,246				11.61
Exercised			—				—
Cancelled			(55,655	)			9.56
Balance at December 31, 2012			4,323,874				8.46
Granted			4,256,971				8.08
Exercised			(537,029	)			5.20
Cancelled			(1,688,135	)			9.45
Balance at December 31, 2013			6,355,681				8.22
Granted			3,181,001				9.40
Exercised			(756,593	)			6.34
Cancelled			(862,085	)			9.88
Balance at December 31, 2014			7,918,004			$	8.69

Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding and Exercisable [Table Text Block]

		Years Ended December 31,
		2014								2013								2012
						Weighted-								Weighted-								Weighted-
						Average								Average								Average
						Exercise								Exercise								Exercise
		Options				Price				Options				Price				Options				Price
Exercisable at end of year			2,237,901			$	9.01				1,770,597			$	8.67				1,142,099			$	7.98
Options vested or expected to vest			7,841,074			$	8.69				6,292,296			$	8.22				4,283,344			$	8.45

Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block]

																		Weighted-
						Weighted-												Average
						Average				Weighted-								Exercise
						Remaining				Average								Price of
	Options			Range of		Contractual				Exercise				Options				Options
	Outstanding			Exercise Prices		Life (in years)				Price				Exercisable				Exercisable
		953,090		$3.80 – $7.00			5.92			$	5.78				662,840			$	5.34
		2,511,808		$7.20			8.01				7.20				531,578				7.20
		2,428,458		$7.61 – $9.05			9.12				8.87				204,669				8.95
		1,991,338		$9.20 – $15.40			7.42				11.27				805,504				12.09
		33,310		$15.41 – $139.20			1.05				36.97				33,310				36.97
		7,918,004		$3.80 – $139.20			7.92				8.69				2,237,901				9.01

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

		December 31,
		2014				2013				2012
Research and development		$	3,329			$	2,562			$	1,617
General and administrative			4,738				8,328				4,115
Stock-based compensation expense included in operating expenses		$	8,067			$	10,890			$	5,732

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		December 31,
		2014				2013				2012
Risk-free interest rate			1.9	%			1.1	%			0.8	%
Dividend yield			—	%			—	%			—	%
Volatility			99.0	%			104.2	%			106.2	%
Expected life (years)			6.0				6.0				5.5

		December 31,
		2014				2013				2012
Risk-free interest rate			0.1	%			0.1	%			0.2	%
Dividend yield			—	%			—	%			—	%
Volatility			53.8	%			76.0	%			77.9	%
Expected life (years)			0.5				0.5				0.5

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