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Note 8 - Income Taxes (Details) (USD $)
 12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Note 8 - Income Taxes (Details) [Line Items]      
Income Tax Expense (Benefit) $ 0us-gaap_IncomeTaxExpenseBenefit $ 0us-gaap_IncomeTaxExpenseBenefit $ 0us-gaap_IncomeTaxExpenseBenefit
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount 32,035,000us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount 22,038,000us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount  
Deferred Tax Assets, Tax Credit Carryforwards, Research 7,667,000us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch 4,792,000us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch  
Unrecognized Tax Benefits that Would Impact Effective Tax Rate 120,000us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate    
Unrecognized Tax Benefits 120,000us-gaap_UnrecognizedTaxBenefits 120,000us-gaap_UnrecognizedTaxBenefits 120,000us-gaap_UnrecognizedTaxBenefits
Domestic Tax Authority [Member]      
Note 8 - Income Taxes (Details) [Line Items]      
Operating Loss Carryforwards 149,573,000us-gaap_OperatingLossCarryforwards
/ us-gaap_IncomeTaxAuthorityAxis
= us-gaap_DomesticCountryMember		    
Deferred Tax Assets, Tax Credit Carryforwards, Research 4,676,000us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch
/ us-gaap_IncomeTaxAuthorityAxis
= us-gaap_DomesticCountryMember		    
State and Local Jurisdiction [Member]      
Note 8 - Income Taxes (Details) [Line Items]      
Operating Loss Carryforwards 148,402,000us-gaap_OperatingLossCarryforwards
/ us-gaap_IncomeTaxAuthorityAxis
= us-gaap_StateAndLocalJurisdictionMember		    
Deferred Tax Assets, Tax Credit Carryforwards, Research $ 4,493,000us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch
/ us-gaap_IncomeTaxAuthorityAxis
= us-gaap_StateAndLocalJurisdictionMember