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Note 8 - Income Taxes (Details) - Components of Defered Tax Assets (USD $) In Thousands, unless otherwise specified	Dec. 31, 2014	Dec. 31, 2013
Deferred tax assets:
Net operating loss carryforward	$ 59,513us-gaap_DeferredTaxAssetsOperatingLossCarryforwards	$ 31,834us-gaap_DeferredTaxAssetsOperatingLossCarryforwards
Research and development credits	7,667us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch	4,792us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch
Stock-based compensation	5,128us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost	4,124us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost
Other, net	964us-gaap_DeferredTaxAssetsOther	487us-gaap_DeferredTaxAssetsOther
Total deferred tax assets	73,272us-gaap_DeferredTaxAssetsGross	41,237us-gaap_DeferredTaxAssetsGross
Valuation allowance for net deferred tax assets	(73,272)us-gaap_DeferredTaxAssetsValuationAllowance	(41,237)us-gaap_DeferredTaxAssetsValuationAllowance
Net deferred taxes	$ 0us-gaap_DeferredTaxAssetsLiabilitiesNet	$ 0us-gaap_DeferredTaxAssetsLiabilitiesNet

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.

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