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Note 11 - Summary of Quarterly Financial Data (Unaudited) (Details) - Quarterly Results of Operations (USD $)
In Thousands, except Per Share data, unless otherwise specified
3 Months Ended 12 Months Ended
Dec. 31, 2014
Sep. 30, 2014
Jun. 30, 2014
Mar. 31, 2014
Dec. 31, 2013
Sep. 30, 2013
Jun. 30, 2013
Mar. 31, 2012
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Operating expenses:                      
Research and development $ 14,195us-gaap_ResearchAndDevelopmentExpense $ 14,731us-gaap_ResearchAndDevelopmentExpense $ 14,279us-gaap_ResearchAndDevelopmentExpense $ 11,628us-gaap_ResearchAndDevelopmentExpense $ 8,538us-gaap_ResearchAndDevelopmentExpense $ 6,165us-gaap_ResearchAndDevelopmentExpense $ 10,748us-gaap_ResearchAndDevelopmentExpense $ 7,065us-gaap_ResearchAndDevelopmentExpense $ 54,833us-gaap_ResearchAndDevelopmentExpense $ 32,516us-gaap_ResearchAndDevelopmentExpense $ 15,174us-gaap_ResearchAndDevelopmentExpense
General and administrative 5,300us-gaap_GeneralAndAdministrativeExpense 4,222us-gaap_GeneralAndAdministrativeExpense 4,512us-gaap_GeneralAndAdministrativeExpense 5,694us-gaap_GeneralAndAdministrativeExpense 5,293us-gaap_GeneralAndAdministrativeExpense 6,500us-gaap_GeneralAndAdministrativeExpense 4,461us-gaap_GeneralAndAdministrativeExpense 5,687us-gaap_GeneralAndAdministrativeExpense 19,728us-gaap_GeneralAndAdministrativeExpense 21,941us-gaap_GeneralAndAdministrativeExpense 8,657us-gaap_GeneralAndAdministrativeExpense
Loss from operations (19,495)us-gaap_IncomeLossFromContinuingOperations (18,953)us-gaap_IncomeLossFromContinuingOperations (18,791)us-gaap_IncomeLossFromContinuingOperations (17,322)us-gaap_IncomeLossFromContinuingOperations (13,831)us-gaap_IncomeLossFromContinuingOperations (12,665)us-gaap_IncomeLossFromContinuingOperations (15,209)us-gaap_IncomeLossFromContinuingOperations (12,752)us-gaap_IncomeLossFromContinuingOperations (76,367)us-gaap_IncomeLossFromContinuingOperations (55,283)us-gaap_IncomeLossFromContinuingOperations (24,430)us-gaap_IncomeLossFromContinuingOperations
Interest income 3us-gaap_InvestmentIncomeInterest           1us-gaap_InvestmentIncomeInterest 1us-gaap_InvestmentIncomeInterest      
Interest expense (227)us-gaap_InterestExpense (224)us-gaap_InterestExpense (220)us-gaap_InterestExpense (216)us-gaap_InterestExpense (212)us-gaap_InterestExpense (209)us-gaap_InterestExpense (205)us-gaap_InterestExpense (202)us-gaap_InterestExpense (887)us-gaap_InterestExpense (828)us-gaap_InterestExpense (605)us-gaap_InterestExpense
Other expense (905)us-gaap_OtherNonoperatingIncomeExpense (17)us-gaap_OtherNonoperatingIncomeExpense             (919)us-gaap_OtherNonoperatingIncomeExpense 2us-gaap_OtherNonoperatingIncomeExpense 6us-gaap_OtherNonoperatingIncomeExpense
Net loss $ (20,624)us-gaap_NetIncomeLoss $ (19,194)us-gaap_NetIncomeLoss $ (19,011)us-gaap_NetIncomeLoss $ (17,538)us-gaap_NetIncomeLoss $ (14,043)us-gaap_NetIncomeLoss $ (12,874)us-gaap_NetIncomeLoss $ (15,413)us-gaap_NetIncomeLoss $ (12,953)us-gaap_NetIncomeLoss $ (76,367)us-gaap_NetIncomeLoss $ (55,283)us-gaap_NetIncomeLoss $ (23,348)us-gaap_NetIncomeLoss
Basis and diluted net loss per share (in Dollars per share) $ (0.71)us-gaap_EarningsPerShareBasicAndDiluted $ (0.66)us-gaap_EarningsPerShareBasicAndDiluted $ (0.78)us-gaap_EarningsPerShareBasicAndDiluted $ (0.74)us-gaap_EarningsPerShareBasicAndDiluted $ (0.75)us-gaap_EarningsPerShareBasicAndDiluted $ (0.84)us-gaap_EarningsPerShareBasicAndDiluted $ (1.01)us-gaap_EarningsPerShareBasicAndDiluted $ (0.85)us-gaap_EarningsPerShareBasicAndDiluted $ (2.87)us-gaap_EarningsPerShareBasicAndDiluted $ (3.42)us-gaap_EarningsPerShareBasicAndDiluted $ (1.91)us-gaap_EarningsPerShareBasicAndDiluted