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Note 5 - Stockholders' Equity (Tables)

3 Months Ended

Mar. 31, 2015

Notes Tables

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

		Three Months Ended March 31 ,
		2015				2014
Research and development		$	806			$	1,262
General and administrative			1,745				1,707
Stock-based compensation expense included in operating expenses		$	2,551			$	2,969
Impact on basic and diluted net loss per share		$	0.09			$	0.13

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		March 31,
		20 15				20 14
Risk-free interest rate			1.6	%			2.0	%
Dividend yield			0.0	%			0.0	%
Volatility			91.7	%			104.1	%
Expected life (years)			6.1				6.0

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

										Weighted-
										Average
						Weighted-				Remaining
						Average				Contractual
		Shares				Exercise				Term
		(in thousands)				Price				(Years)
Balance at January 1, 2015			7,918			$	8.69				7.92
Granted			54			$	11.52
Exercised			(352	)		$	8.18
Expired and forfeited			(327	)		$	10.67
Balance at March 31, 2015			7,293			$	8.65				8.31

X

- Definition

Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

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