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Note 5 - Stockholders' Equity (Tables)

6 Months Ended

Jun. 30, 2015

Notes Tables

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

		Three Months Ended June 30 ,								Six Months Ended June 30 ,
		2015				2014				2015				2014
Research and development		$	919			$	446			$	1,725			$	1,708
General and administrative			2,222				634				3,966				2,341
Stock-based compensation expense included in operating expenses		$	3,141			$	1,080			$	5,691			$	4,049
Impact on basic and diluted net loss per share		$	0.10			$	0.04			$	0.19			$	0.17

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		June 30,
		20 15				20 14
Risk-free interest rate			1.7	%			2.0	%
Dividend yield			0.0	%			0.0	%
Volatility			91.0	%			104.0	%
Expected life (years)			6				6

Schedule of Share-based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block]

		June 30,
		20 15				20 14
Risk-free interest rate			0.1	%			0.1	%
Dividend yield			0.0	%			0.0	%
Volatility			59.1	%			58.9	%
Expected life (months)			6				6

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

										Weighted-
										Average
						Weighted-				Remaining
						Average				Contractual
		Shares				Exercise				Term
		(in thousands)				Price				(Years)
Balance at January 1, 2015			7,918			$	8.69				7.92
Granted			125			$	19.13
Exercised			(713	)		$	8.84
Expired and forfeited			(345	)		$	11.30
Balance at June 30, 2015			6,985			$	8.73				8.08

X

- Definition

Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

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