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Note 5 - Stockholders' Equity - Allocation of the Recognized Cost (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2015
Jun. 30, 2014
Jun. 30, 2015
Jun. 30, 2014
Research and Development Expense [Member]        
Share-based compensation expense $ 919 $ 446 $ 1,725 $ 1,708
General and Administrative Expense [Member]        
Share-based compensation expense 2,222 634 3,966 2,341
Share-based compensation expense $ 3,141 $ 1,080 $ 5,691 $ 4,049
Impact on basic and diluted net loss per share (in dollars per share) $ 0.10 $ 0.04 $ 0.19 $ 0.17