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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 6 Months Ended
Jun. 30, 2015
Jun. 30, 2014
Operating activities:    
Net loss $ (43,677,000) $ (36,549,000)
Adjustments to reconcile net loss to net cash used for operating activities:    
Depreciation and amortization 323,000 239,000
Stock-based compensation expense 5,691,000 4,049,000
Amortization of Debt Discount (Premium) 305,000 $ 281,000
Gain on disposal of property and equipment (118,000)  
Changes in operating assets and liabilities:    
Prepaid expenses and other assets (838,000) $ 120,000
Accounts payable 438,000 505,000
Accrued clinical liabilities 2,531,000 1,932,000
Accrued payroll and employee-related liabilities (447,000) (731,000)
Other accrued expenses 304,000 1,965,000
Net cash used for operating activities (35,488,000) (28,189,000)
Investing activities:    
Purchases of property and equipment (531,000) $ (335,000)
Proceeds from sale of property and equipment 241,000  
Net cash used for investing activities (290,000) $ (335,000)
Financing activities:    
Proceeds from purchases under the Employee Stock Purchase Plan 118,000 19,000
Proceeds from stock option exercises 6,306,000 2,308,000
Net proceeds from sale of common stock and/or pre-funded warrants 128,205,000 58,922,000
Net cash provided by financing activities 134,629,000 61,249,000
Net increase in cash and cash equivalents 98,851,000 32,725,000
Cash and cash equivalents at beginning of period 72,675,000 72,287,000
Cash and cash equivalents at end of period $ 171,526,000 $ 105,012,000