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Note 5 - Stockholders' Equity (Tables)

9 Months Ended

Sep. 30, 2015

Notes Tables

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

		Three Months Ended September 30 ,								Nine Months Ended September 30 ,
		2015				2014				2015				2014
Research and development		$	927			$	715			$	2,652			$	2,423
General and administrative			1,894				1,045				5,860				3,386
Stock-based compensation expense included in operating expenses		$	2,821			$	1,760			$	8,512			$	5,809
Impact on basic and diluted net loss per share		$	0.08			$	0.06			$	0.27			$	0.23

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		September 30,
		20 15				20 14
Risk-free interest rate			1.7	%			2.0	%
Dividend yield			0.0	%			0.0	%
Volatility			90.7	%			102.9	%
Expected life (years)			6				6

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

										Weighted-
										Average
						Weighted-				Remaining
						Average				Contractual
		Shares				Exercise				Term
		(in thousands)				Price				(Years)
Balance at January 1, 2015			7,918			$	8.69				7.92
Granted			375			$	29.26
Exercised			(883	)		$	8.97
Expired and forfeited			(450	)		$	11.02
Balance at September 30, 2015			6,960			$	9.61				7.90

X

- Definition

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