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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 9 Months Ended
Sep. 30, 2015
Sep. 30, 2014
Operating activities:    
Net loss $ (66,349,000) $ (55,743,000)
Adjustments to reconcile net loss to net cash used for operating activities:    
Depreciation and amortization 498,000 389,000
Stock-based compensation expense 8,512,000 5,809,000
Amortization of Debt Discount (Premium) 463,000 $ 425,000
Gain on disposal of property and equipment (118,000)
Changes in operating assets and liabilities:    
Prepaid expenses and other assets (993,000) $ (2,392,000)
Accounts payable 186,000 211,000
Accrued clinical liabilities 1,356,000 2,757,000
Accrued payroll and employee-related liabilities 658,000 35,000
Other accrued expenses 411,000 1,084,000
Net cash used for operating activities (55,376,000) (47,425,000)
Investing activities:    
Purchases of property and equipment (783,000) $ (417,000)
Proceeds from sale of property and equipment 241,000
Net cash used for investing activities (542,000) $ (417,000)
Financing activities:    
Proceeds from purchases under the Employee Stock Purchase Plan 118,000 19,000
Proceeds from stock option exercises 7,915,000 2,832,000
Net proceeds from sale of common stock and/or pre-funded warrants 128,199,000 58,916,000
Net cash provided by financing activities 136,232,000 61,767,000
Net increase in cash and cash equivalents 80,314,000 13,925,000
Cash and cash equivalents at beginning of period 72,675,000 72,287,000
Cash and cash equivalents at end of period $ 152,989,000 $ 86,212,000