<SEC-DOCUMENT>0001193125-15-217970-index.html : 20150609
<SEC-HEADER>0001193125-15-217970.hdr.sgml : 20150609
<ACCEPTANCE-DATETIME>20150609160900
ACCESSION NUMBER:		0001193125-15-217970
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		5
FILED AS OF DATE:		20150609
DATE AS OF CHANGE:		20150609

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HERON THERAPEUTICS, INC. /DE/
		CENTRAL INDEX KEY:			0000818033
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				942875566
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-198862
		FILM NUMBER:		15921008

	BUSINESS ADDRESS:	
		STREET 1:		123 SAGINAW DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063
		BUSINESS PHONE:		6503662626

	MAIL ADDRESS:	
		STREET 1:		123 SAGINAW DRIVE
		STREET 2:		123 SAGINAW DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AP PHARMA INC /DE/
		DATE OF NAME CHANGE:	20010511

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADVANCED POLYMER SYSTEMS INC /DE/
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
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<SEQUENCE>1
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<DESCRIPTION>424B5
<TEXT>
Document 1 - file: d939145d424b5.htm

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<TEXT>
Document 2 - file: g939145g00t18.jpg

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<SEQUENCE>3
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<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: g939145g18v80.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>g939145g45o11.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: g939145g45o11.jpg

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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>g939145g63s51.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: g939145g63s51.jpg

</DOCUMENT>
</SEC-DOCUMENT>