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Note 10 - Summary of Quarterly Consolidated Financial Data (Unaudited) (Tables) | 12 Months Ended
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Dec. 31, 2015
Notes Tables |
Schedule of Quarterly Financial Information [Table Text Block] |
|  | 2015 |
|  | First Quarter |  |  | Second Quarter |  |  | Third Quarter |  |  | Fourth Quarter |
|  | (In thousands, except per share amounts) |
Operating expenses: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development |  | $ | 14,504 |  |  | $ | 16,175 |  |  | $ | 14,241 |  |  | $ | 16,263 |
General and administrative |  |  | 5,856 |  |  |  | 6,839 |  |  |  | 8,250 |  |  |  | 14,797 |
Loss from operations |  |  | (20,360 | ) |  |  | (23,014 | ) |  |  | (22,491 | ) |  |  | (31,060 | )
Interest income |  |  | 22 |  |  |  | 26 |  |  |  | 61 |  |  |  | 65 |
Interest expense |  |  | (232 | ) |  |  | (237 | ) |  |  | (242 | ) |  |  | (247 | )
Other expense |  |  | — |  |  |  | 118 |  |  |  | — |  |  |  | — |
Net loss |  | $ | (20,570 | ) |  | $ | (23,107 | ) |  | $ | (22,672 | ) |  | $ | (31,242 | )
Basis and diluted net loss per share |  | $ | (0.70 | ) |  | $ | (0.74 | ) |  | $ | (0.63 | ) |  | $ | (0.87 | )
|  | 2014 |
|  | First Quarter |  |  | Second Quarter |  |  | Third Quarter |  |  | Fourth Quarter |
|  | (In thousands, except per share amounts) |
Operating expenses: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development |  | $ | 11,628 |  |  | $ | 14,279 |  |  | $ | 14,731 |  |  | $ | 14,195 |
General and administrative |  |  | 5,694 |  |  |  | 4,512 |  |  |  | 4,222 |  |  |  | 5,300 |
Loss from operations |  |  | (17,322 | ) |  |  | (18,791 | ) |  |  | (18,953 | ) |  |  | (19,495 | )
Interest income |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 3 |
Interest expense |  |  | (216 | ) |  |  | (220 | ) |  |  | (224 | ) |  |  | (227 | )
Other expense |  |  | — |  |  |  | — |  |  |  | (17 | ) |  |  | (905 | )
Net loss |  | $ | (17,538 | ) |  | $ | (19,011 | ) |  | $ | (19,194 | ) |  | $ | (20,624 | )
Basis and diluted net loss per share |  | $ | (0.74 | ) |  | $ | (0.78 | ) |  | $ | (0.66 | ) |  | $ | (0.71 | )

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- Definition Tabular disclosure of the quarterly financial data in the annual financial statements. The disclosure includes financial information for each fiscal quarter for the current and previous year, including revenues, gross profit, income (loss) before extraordinary items and cumulative effect of a change in accounting principle and earnings per share data. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a)-(j) -URI http://asc.fasb.org/extlink&oid=51825399&loc=d3e1280-108306 + Details
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