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Consolidated Statements of Stockholders' Equity - USD ($) | Note Warrant [Member] Common Stock [Member] | Note Warrant [Member] Additional Paid-in Capital [Member] | Note Warrant [Member] Retained Earnings [Member] | Note Warrant [Member] | Common Stock [Member] | Additional Paid-in Capital [Member] | AOCI Attributable to Parent [Member] | Retained Earnings [Member] | Total
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2012 |  |  |  |  | 15,111,000 |  |  |  |
Balance at Dec. 31, 2012 |  |  |  |  | $ 152,000 | $ 235,253,000 |  | $ (183,587,000) | $ 51,818,000
Issuance of common stock in a public offering, net (in shares) |  |  |  |  | 7,706,000 |  |  |  |
Issuance of common stock in a public offering, net | $ 2,000 | $ 598,000 |  | $ 600,000 | $ 77,000 | 57,725,000 |  |  | 57,802,000
Conversion benefit included in Convertible Notes issued |  |  |  |  |  | 291,000 |  |  | 291,000
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  |  | 6,000 |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan |  |  |  |  | $ 1,000 | 33,000 |  |  | $ 34,000
Issuance of common stock upon exercise of stock options (in shares) |  |  |  |  | 537,000 |  |  |  | 537,029
Issuance of common stock upon exercise of stock options |  |  |  |  | $ 5,000 | 2,788,000 |  |  | $ 2,793,000
Issuance of common stock upon exercise of warrants (in shares) | 212,000 |  |  |  |  |  |  |  |
Stock-based compensation expense |  |  |  |  |  | 10,890,000 |  |  | 10,890,000
Net loss |  |  |  |  |  |  |  | $ (55,283,000) | (55,283,000)
Balance (in shares) at Dec. 31, 2013 |  |  |  |  | 23,572,000 |  |  |  |
Balance at Dec. 31, 2013 |  |  |  |  | $ 237,000 | 307,578,000 |  | $ (238,870,000) | 68,945,000
Issuance of common stock upon exercise of stock options |  |  |  |  | $ 5,000 | 2,788,000 |  |  | 2,793,000
Net unrealized loss on short-term investments |  |  |  |  |  |  |  |  | 0
Comprehensive loss |  |  |  |  |  |  |  |  | (55,283,000)
Issuance of common stock in a public offering, net | $ 3,000 | (3,000) |  |  |  |  |  |  |
Conversion benefit included in Convertible Notes issued |  |  |  |  |  | 309,000 |  |  | 309,000
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  |  | 12,000 |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan |  |  |  |  |  | 91,000 |  |  | $ 91,000
Issuance of common stock upon exercise of stock options (in shares) |  |  |  |  | 588,000 |  |  |  | 756,593
Issuance of common stock upon exercise of stock options |  |  |  |  | $ 5,000 | 3,096,000 |  |  | $ 3,101,000
Issuance of common stock upon exercise of warrants (in shares) | 304,000 |  |  |  |  |  |  |  |
Stock-based compensation expense |  |  |  |  |  | 8,067,000 |  |  | 8,067,000
Net loss |  |  |  |  |  |  |  | $ (76,367,000) | (76,367,000)
Balance (in shares) at Dec. 31, 2014 |  |  |  |  | 29,227,000 |  |  |  |
Balance at Dec. 31, 2014 |  |  |  |  | $ 292,000 | 378,007,000 |  | $ (315,237,000) | 63,062,000
Issuance of common stock and pre-funded warrants in a public offering, net (in shares) |  |  |  |  | 4,751,000 |  |  |  |
Issuance of common stock and pre-funded warrants in a public offering, net |  |  |  |  | $ 47,000 | 58,869,000 |  |  | 58,916,000
Issuance of common stock in a public offering, net |  |  |  |  | 47,000 | 58,869,000 |  |  | 58,916,000
Issuance of common stock upon exercise of stock options |  |  |  |  | $ 5,000 | 3,096,000 |  |  | 3,101,000
Net unrealized loss on short-term investments |  |  |  |  |  |  |  |  | 0
Comprehensive loss |  |  |  |  |  |  |  |  | (76,367,000)
Issuance of common stock in a public offering, net (in shares) |  |  |  |  | 5,520,000 |  |  |  |
Issuance of common stock in a public offering, net | $ 3,000 | $ (3,000) |  |  |  |  |  |  |
Conversion benefit included in Convertible Notes issued |  |  |  |  |  | 328,000 |  |  | 328,000
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  |  |  |  | 31,000 |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan |  |  |  |  |  | 257,000 |  |  | $ 257,000
Issuance of common stock upon exercise of stock options (in shares) |  |  |  |  | 1,042,000 |  |  |  | 1,042,343
Issuance of common stock upon exercise of stock options |  |  |  |  | $ 11,000 | 9,524,000 |  |  | $ 9,535,000
Issuance of common stock upon exercise of warrants (in shares) | 286,000 |  |  |  |  |  |  |  |
Stock-based compensation expense |  |  |  |  |  | 14,360,000 |  |  | 14,360,000
Net loss |  |  |  |  |  |  |  | $ (97,591,000) | (97,591,000)
Balance (in shares) at Dec. 31, 2015 |  |  |  |  | 36,106,000 |  |  |  |
Balance at Dec. 31, 2015 |  |  |  |  | $ 361,000 | 530,617,000 | $ (40,000) | $ (412,828,000) | 118,110,000
Issuance of common stock and pre-funded warrants in a public offering, net |  |  |  |  | 55,000 | 128,144,000 |  |  | 128,199,000
Issuance of common stock in a public offering, net |  |  |  |  | 55,000 | 128,144,000 |  |  | 128,199,000
Issuance of common stock upon exercise of stock options |  |  |  |  | $ 11,000 | $ 9,524,000 |  |  | 9,535,000
Net unrealized loss on short-term investments |  |  |  |  |  |  | $ (40,000) |  | (40,000)
Comprehensive loss |  |  |  |  |  |  |  |  | $ (97,631,000)

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