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Note 7 - Stockholders' Equity (Tables) | 12 Months Ended
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Dec. 31, 2015
Notes Tables |
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] |
|  | Number of Shares Outstanding |  |  | Exercise Price |  | Expiration Date
Issued to private placement investors in July 2011 |  |  | 2,965,477 |  |  | $ | 3.60 |  | 07/01/2016
Issued in a public offering in June 2014 |  |  | 600,000 |  |  | $ | 0.01 |  | 06/30/2021
Total warrants outstanding |  |  | 3,565,477 |  |  |  |  |  |
Common Stock Reserved for Future Issuance [Table Text Block] |
|  | Number of Shares |
Stock options outstanding |  |  | 8,434,988 |
Stock options available for grant |  |  | 3,880,849 |
Employee stock purchase plan |  |  | 99,532 |
Warrants outstanding |  |  | 3,565,477 |
Common stock underlying Convertible Notes outstanding |  |  | 7,086,560 |
Total shares reserved for future issuance |  |  | 23,067,406 |
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] |
|  | Outstanding Options |
|  |  |  |  |  | Weighted- |
|  |  |  |  |  | Average |
|  | Number of |  |  | Exercise |
|  | Shares |  |  | Price |
Balance at December 31, 2012 |  |  | 4,323,874 |  |  | $ | 8.46 |
Granted |  |  | 4,256,971 |  |  |  | 8.08 |
Exercised |  |  | (537,029 | ) |  |  | 5.20 |
Cancelled |  |  | (1,688,135 | ) |  |  | 9.45 |
Balance at December 31, 2013 |  |  | 6,355,681 |  |  |  | 8.22 |
Granted |  |  | 3,181,001 |  |  |  | 9.40 |
Exercised |  |  | (756,593 | ) |  |  | 6.34 |
Cancelled |  |  | (862,085 | ) |  |  | 9.88 |
Balance at December 31, 2014 |  |  | 7,918,004 |  |  |  | 8.69 |
Granted |  |  | 2,134,505 |  |  |  | 28.95 |
Exercised |  |  | (1,042,343 | ) |  |  | 9.15 |
Cancelled |  |  | (575,178 | ) |  |  | 10.42 |
Balance at December 31, 2015 |  |  | 8,434,988 |  |  | $ | 13.64 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding and Exercisable [Table Text Block] |
|  | Years Ended December 31, |
|  | 2015 |  |  | 2014 |  |  | 2013 |
|  |  |  |  |  | Weighted- |  |  |  |  |  |  | Weighted- |  |  |  |  |  |  | Weighted- |
|  |  |  |  |  | Average |  |  |  |  |  |  | Average |  |  |  |  |  |  | Average |
|  |  |  |  |  | Exercise |  |  |  |  |  |  | Exercise |  |  |  |  |  |  | Exercise |
|  | Options |  |  | Price |  |  | Options |  |  | Price |  |  | Options |  |  | Price |
Exercisable at end of year |  |  | 2,587,392 |  |  | $ | 8.72 |  |  |  | 2,237,901 |  |  | $ | 9.01 |  |  |  | 1,770,597 |  |  | $ | 8.67 |
Options vested or expected to vest |  |  | 8,059,481 |  |  | $ | 13.38 |  |  |  | 7,841,074 |  |  | $ | 8.69 |  |  |  | 6,292,296 |  |  | $ | 8.22 |
Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block] |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Weighted- |
|  |  |  |  |  |  |  |  |  |  | Weighted- |  |  |  |  |  |  |  |  |  |  | Average |
|  |  |  |  |  |  |  |  |  |  | Average |  |  | Weighted- |  |  |  |  |  |  | Exercise |
|  |  |  |  |  |  |  |  |  |  | Remaining |  |  | Average |  |  |  |  |  |  | Price of |
| Options |  |  | Range of |  |  | Contractual |  |  | Exercise |  |  | Options |  |  | Options |
| Outstanding |  |  | Exercise Prices |  |  | Life (in years) |  |  | Price |  |  | Exercisable |  |  | Exercisable |
|  | 702,903 |  |  |  | $3.80 | – | $7.00 |  |  |  | 6.31 |  |  | $ | 5.92 |  |  |  | 466,373 |  |  | $ | 5.38 |
|  | 2,302,688 |  |  |  |  | $7.20 |  |  |  |  | 7.33 |  |  |  | 7.20 |  |  |  | 711,687 |  |  |  | 7.20 |
|  | 2,047,712 |  |  |  | $7.61 | – | $9.05 |  |  |  | 8.30 |  |  |  | 8.91 |  |  |  | 711,561 |  |  |  | 8.84 |
|  | 1,702,732 |  |  |  | $9.20 | – | $28.30 |  |  |  | 7.23 |  |  |  | 14.89 |  |  |  | 692,974 |  |  |  | 12.17 |
|  | 1,678,953 |  |  |  | $28.73 | – | $128.00 |  |  |  | 9.71 |  |  |  | 30.23 |  |  |  | 4,797 |  |  |  | 42.60 |
|  | 8,434,988 |  |  |  | $3.80 | – | $128.00 |  |  |  | 7.94 |  |  |  | 13.64 |  |  |  | 2,587,392 |  |  |  | 8.72 |
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] |
|  | December 31, |
|  | 2015 |  |  | 2014 |  |  | 2013 |
Research and development |  | $ | 4,701 |  |  | $ | 3,329 |  |  | $ | 2,562 |
General and administrative |  |  | 9,659 |  |  |  | 4,738 |  |  |  | 8,328 |
Stock-based compensation expense included in operating expenses |  | $ | 14,360 |  |  | $ | 8,067 |  |  | $ | 10,890 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | December 31, |
|  | 2015 |  |  | 2014 |  |  | 2013 |
Risk-free interest rate |  |  | 1.7 | % |  |  | 1.9 | % |  |  | 1.1 | %
Dividend yield |  |  | — | % |  |  | — | % |  |  | — | %
Volatility |  |  | 92.7 | % |  |  | 99.0 | % |  |  | 104.2 | %
Expected life (years) |  |  | 6 |  |  |  | 6 |  |  |  | 6 |
|  | December 31, |
|  | 2015 |  |  | 2014 |  |  | 2013 |
Risk-free interest rate |  |  | 0.1 | % |  |  | 0.1 | % |  |  | 0.1 | %
Dividend yield |  |  | — | % |  |  | — | % |  |  | — | %
Volatility |  |  | 86.7 | % |  |  | 53.8 | % |  |  | 76.0 | %
Expected life (months) |  |  | 6 |  |  |  | 6 |  |  |  | 6 |

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