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Note 8 - Income Taxes (Details Textual) - USD ($) | 12 Months Ended
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Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Domestic Tax Authority [Member] | Stock Compensation Plan [Member] |  |  |
Operating Loss Carryforwards | $ 4,235,000 |  |
Domestic Tax Authority [Member] |  |  |
Operating Loss Carryforwards | 242,769,000 |  |
Deferred Tax Assets, Tax Credit Carryforwards, Research | 7,434,000 |  |
State and Local Jurisdiction [Member] | Stock Compensation Plan [Member] |  |  |
Operating Loss Carryforwards | 4,235,000 |  |
State and Local Jurisdiction [Member] |  |  |
Operating Loss Carryforwards | 233,305,000 |  |
Deferred Tax Assets, Tax Credit Carryforwards, Research | 5,639,000 |  |
Income Tax Expense (Benefit) | 0 | $ 0 | $ 0
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued | 0 | 0 |
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount | 40,445,000 | 32,035,000 |
Deferred Tax Assets, Tax Credit Carryforwards, Research | $ 11,181,000 | 7,667,000 |
Unrecognized Tax Benefits that Would Impact Effective Tax Rate |  | 120,000 |
Unrecognized Tax Benefits |  | $ 120,000 |

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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible research tax credit carryforwards. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32621-109319 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32632-109319 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 3 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32559-109319 + Details
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- Definition Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 9 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32639-109319 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(h)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Income Tax Expense (or Benefit) -URI http://asc.fasb.org/extlink&oid=6515339 + Details
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