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Note 7 - Stockholders' Equity (Details Textual) |  | 1 Months Ended | 12 Months Ended | 68 Months Ended | 97 Months Ended |  |
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Jan. 13, 2014 | Jun. 30, 2015 USD ($) $ / shares shares | May. 31, 2015 shares | Jun. 30, 2014 USD ($) $ / shares shares | May. 31, 2014 shares | Nov. 30, 2013 USD ($) $ / shares shares | Jun. 30, 2011 $ / shares shares | May. 31, 2010 shares | May. 31, 2009 shares | Dec. 31, 2007 shares | Dec. 31, 2015 USD ($) $ / shares shares | Dec. 31, 2014 USD ($) $ / shares shares | Dec. 31, 2013 USD ($) $ / shares shares | Dec. 31, 2015 USD ($) $ / shares shares | Dec. 31, 2015 USD ($) $ / shares shares | Sep. 13, 2013 shares | Sep. 12, 2013 shares
Private Placement 2011 [Member] | Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues |  |  |  |  |  |  |  |  |  |  | 285,713 | 303,614 |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Exercised |  |  |  |  |  |  |  |  |  |  | 343,813 | 460,706 |  |  |  |  |
Private Placement 2011 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Warrant Exercises | $ |  |  |  |  |  |  |  |  |  |  | $ 0 |  | $ 600,000 |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  |  |  |  | 4,000,000 |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares |  |  |  |  |  |  | $ 3.60 |  |  |  |  |  |  |  |  |  |
Beneficial Ownership after Conversion |  |  |  |  |  |  | 9.99% |  |  |  |  |  |  |  |  |  |
Notice Period Associated with Beneficial Ownership Percentage Limitation Convertible Notes |  |  |  |  |  |  | 61 days |  |  |  |  |  |  |  |  |  |
Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity Note, Stock Split, Conversion Ratio | 20 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues |  | 5,500,000 |  | 4,800,000 |  | 7,700,000 |  |  |  |  |  |  |  |  |  |  |
Sale of Stock, Price Per Share | $ / shares |  | $ 24.75 |  | $ 11.75 |  | $ 8 |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Common Stock | $ |  |  |  |  |  | $ 57,800,000 |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs | $ |  | $ 8,400,000 |  |  |  | $ 3,900,000 |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance or Sale of Equity | $ |  | $ 128,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period |  |  |  |  |  |  |  |  |  |  | 1,042,000 | 588,000 | 537,000 |  |  |  |
Common Stock and Prefunded Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs | $ |  |  |  | $ 4,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance or Sale of Equity | $ |  |  |  | $ 58,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Pre-funded Warrants[Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  | 600,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Share Price | $ / shares |  |  |  | $ 11.74 |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares |  |  |  | $ 0.01 |  |  |  |  |  |  |  |  |  |  |  |  |
Weighted Average [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares |  |  |  |  |  |  |  |  |  |  |  | $ 3 |  |  |  |  |
Employee Stock Purchase Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized |  |  | 100,000 |  | 25,000 |  | 25,000 |  | 10,000 | 5,000 |  |  |  |  | 175,000 |  |
Share-based Compensation Arrangement by Share-based Payment Award Maximum Employee Earnings with held to Purchase Common Stock Percent |  |  |  |  |  |  |  |  |  |  | 10.00% |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award Discount on Stock Price |  |  |  |  |  |  |  |  |  |  |  | 85.00% |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award Eligible Participants Percent |  |  |  |  |  |  |  |  |  |  | 36.00% |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period |  |  |  |  |  |  |  |  |  |  | 30,361 | 12,028 | 5,630 |  |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 8.46 | $ 7.59 | $ 6.12 |  |  |  |
Common Stock, Shares, Issued |  |  |  |  |  |  |  |  |  |  | 75,468 |  |  | 75,468 | 75,468 |  |
Common Stock, Capital Shares Reserved for Future Issuance |  |  |  |  |  |  |  |  |  |  | 99,532 |  |  | 99,532 | 99,532 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 21.92 | 7.40 | 6.53 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Per Share Weighted-average Fair Value Price of Shares Purchased | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 8.23 | $ 3.06 | $ 3.01 | $ 8.23 | $ 8.23 |  |
Equity Incentive Plan 2007 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized |  |  | 4,300,000 |  | 1,750,000 |  | 4,500,000 | 100,000 |  |  |  |  |  | 10,800,000 |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized |  |  |  |  |  |  |  |  |  | 150,000 |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant |  |  |  |  |  |  |  |  |  |  | 3,880,849 |  |  | 3,880,849 | 3,880,849 |  |
Proceeds from Warrant Exercises | $ |  |  |  |  |  |  |  |  |  |  |  |  | $ 600,000 |  |  |  |
Common Stock, Shares Authorized |  |  |  |  |  |  |  |  |  |  | 75,000,000 | 75,000,000 |  | 75,000,000 | 75,000,000 | 75,000,000 | 1,500,000,000
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  |  |  |  |  |  |  |  | 3,565,477 |  |  | 3,565,477 | 3,565,477 |  |
Proceeds from Issuance or Sale of Equity | $ |  |  |  |  |  |  |  |  |  |  | $ 128,199,000 | $ 58,916,000 | $ 57,802,000 |  |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 9.15 | $ 6.34 |  |  |  |  |
Common Stock, Shares, Issued |  |  |  |  |  |  |  |  |  |  | 36,106,000 | 29,227,000 |  | 36,106,000 | 36,106,000 |  |
Common Stock, Capital Shares Reserved for Future Issuance |  |  |  |  |  |  |  |  |  |  | 23,067,406 |  |  | 23,067,406 | 23,067,406 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant |  |  |  |  |  |  |  |  |  |  | 3,880,849 |  |  | 3,880,849 | 3,880,849 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period |  |  |  |  |  |  |  |  |  |  | 10 years |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |  |  |  |  |  |  |  |  |  |  | 4 years |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period |  |  |  |  |  |  |  |  |  |  | 1,042,343 | 756,593 | 537,029 |  |  |  |
Proceeds from Stock Options Exercised | $ |  |  |  |  |  |  |  |  |  |  | $ 9,535,000 | $ 3,101,000 | $ 2,793,000 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period |  |  |  |  |  |  |  |  |  |  | 503,343 |  |  |  |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 9.16 |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period |  |  |  |  |  |  |  |  |  |  | 71,835 |  |  |  |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 19.24 |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term |  |  |  |  |  |  |  |  |  |  | 6 years 255 days |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value | $ |  |  |  |  |  |  |  |  |  |  | $ 13,882,000 | 3,377,000 |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value | $ |  |  |  |  |  |  |  |  |  |  | $ 46,603,000 | $ 14,654,000 |  | $ 46,603,000 | $ 46,603,000 |  |
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Number of Outstanding Options |  |  |  |  |  |  |  |  |  |  | 8,434,988 |  |  | 8,434,988 | 8,434,988 |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized | $ |  |  |  |  |  |  |  |  |  |  | $ 63,865,000 |  |  | $ 63,865,000 | $ 63,865,000 |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition |  |  |  |  |  |  |  |  |  |  | 2 years 109 days |  |  |  |  |  |

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- Definition The purchase price of stock from 1997 Employee Stock Purchase Plan will be the lower of the closing price of common stock on: (i) the first trading day in the enrollment period, as defined in the Purchase Plan, in which the purchase is made, or (ii) the purchase date. + References No definition available. + Details
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- Definition Total number of common shares of an entity that have been sold or granted to shareholders (includes common shares that were issued, repurchased and remain in the treasury). These shares represent capital invested by the firm's shareholders and owners, and may be all or only a portion of the number of shares authorized. Shares issued include shares outstanding and shares held in the treasury. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.29) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 30 -Article 5 + Details
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- Definition The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (j) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3255-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition Period which an employee's right to exercise an award is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The maximum number of shares (or other type of equity) originally approved (usually by shareholders and board of directors), net of any subsequent amendments and adjustments, for awards under the equity-based compensation plan. As stock or unit options and equity instruments other than options are awarded to participants, the shares or units remain authorized and become reserved for issuance under outstanding awards (not necessarily vested). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(3) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Amount of accumulated difference between fair value of underlying shares on dates of exercise and exercise price on options exercised (or share units converted) into shares. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Number of options or other stock instruments for which the right to exercise has lapsed under the terms of the plan agreements. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv)(4) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv)(3) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Number of share instruments newly issued under a share-based compensation plan. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Weighted average price at which option holders acquired shares when converting their stock options into shares. + References No definition available. + Details
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- Definition Weighted average price at which grantees could have acquired the underlying shares with respect to stock options of the plan that expired. + References No definition available. + Details
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- Definition The number of shares reserved for issuance pertaining to the outstanding stock options as of the balance sheet date for all option plans in the customized range of exercise prices. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(i)-(ii) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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