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Note 4 - Balance Sheet Details (Tables) | 12 Months Ended
--- | ---
Dec. 31, 2015
Notes Tables |
Available-for-sale Securities [Table Text Block] |
|  | December 31, 201 5 |
|  |  |  |  |  | Gross |  |  | Gross |  |  |  |  |
|  | Amortized |  |  | Unrealized |  |  | Unrealized |  |  | Estimated |
|  | Cost |  |  | Gains |  |  | Losses |  |  | Fair Value |
United States corporate debt |  | $ | 28,750 |  |  | $ | — |  |  | $ | (35 | ) |  | $ | 28,715 |
Foreign corporate debt |  |  | 4,927 |  |  |  | — |  |  |  | (5 | ) |  |  | 4,922 |
United States commercial paper |  |  | 7,770 |  |  |  | — |  |  |  | — |  |  |  | 7,770 |
Foreign commercial paper |  |  | 15,579 |  |  |  | — |  |  |  | — |  |  |  | 15,579 |
Total |  | $ | 57,026 |  |  | $ | — |  |  | $ | (40 | ) |  | $ | 56,986 |
Property, Plant and Equipment [Table Text Block] |
|  | December 31, |
|  | 2015 |  |  | 2014 |
Scientific equipment |  | $ | 5,593 |  |  | $ | 4,793 |
Computer equipment and software |  |  | 1,272 |  |  |  | 1,133 |
Furniture, fixtures and office equipment |  |  | 352 |  |  |  | 351 |
Leasehold improvements |  |  | 1,384 |  |  |  | 1,376 |
|  |  | 8,601 |  |  |  | 7,653 |
Less: accumulated depreciation and amortization |  |  | (5,552 | ) |  |  | (4,833 | )
|  | $ | 3,049 |  |  | $ | 2,820 |
Schedule of Accrued Liabilities [Table Text Block] |
|  | December 31, |
|  | 20 15 |  |  | 2014 |
Accrued employee salaries and benefits |  | $ | 1,863 |  |  | $ | 719 |
Accrued bonuses |  |  | 2,965 |  |  |  | 2,012 |
Total accrued payroll and employee liabilities |  | $ | 4,828 |  |  | $ | 2,731 |
|  | December 31, |
|  | 2015 |  |  | 2014 |
Accrued consulting and professional fees |  | $ | 3,914 |  |  | $ | 1,775 |
Accrued accounts payable |  |  | 36 |  |  |  | 886 |
Deferred rent |  |  | 61 |  |  |  | 105 |
Other accrued liabilities |  |  | 143 |  |  |  | 165 |
Total other accrued expense |  | $ | 4,154 |  |  | $ | 2,931 |

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- Definition Tabular disclosure of available-for-sale securities which includes, but is not limited to, changes in the cost basis and fair value, fair value and gross unrealized gain (loss), fair values by type of security, contractual maturity and classification, amortized cost basis, contracts to acquire securities to be accounted for as available-for-sale, debt maturities, transfers to trading, change in net unrealized holding gain (loss) net of tax, continuous unrealized loss position fair value, aggregate losses qualitative disclosures, other than temporary impairment (OTTI) losses or other disclosures related to available for sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 320 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6957658&loc=d3e62557-112803 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 50 -Paragraph 7 -URI http://asc.fasb.org/extlink&oid=27724398&loc=d3e27337-111563 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=27724398&loc=d3e27198-111563 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 320 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6957658&loc=d3e62586-112803 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=27724398&loc=d3e27161-111563 Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 50 -Paragraph 9 -URI http://asc.fasb.org/extlink&oid=27724398&loc=d3e27357-111563 Reference 7: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=27724398&loc=d3e27290-111563 + Details
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