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Note 4 - Balance Sheet Details (Tables)
 12 Months Ended
Dec. 31, 2015
Notes Tables  
Available-for-sale Securities [Table Text Block]
 
 
December 31, 201
5
 
 
 
 
 
 
 
Gross
 
 
Gross
 
 
 
 
 
 
 
Amortized
 
 
Unrealized
 
 
Unrealized
 
 
Estimated
 
 
 
Cost
 
 
Gains
 
 
Losses
 
 
Fair Value
 
United States corporate debt
   $ 28,750     $ —     $ (35
)
   $ 28,715  
Foreign corporate debt
     4,927       —       (5
)
     4,922  
United States commercial paper
     7,770       —       —       7,770  
Foreign commercial paper
     15,579       —       —       15,579  
Total
   $ 57,026     $ —     $ (40
)
   $ 56,986  
Property, Plant and Equipment [Table Text Block]
 
 
December 31,
 
 
 
2015
 
 
2014
 
Scientific equipment
   $ 5,593     $ 4,793  
Computer equipment and software
     1,272       1,133  
Furniture, fixtures and office equipment
     352       351  
Leasehold improvements
     1,384       1,376  
      8,601       7,653  
Less: accumulated depreciation and amortization
     (5,552
)
     (4,833
)
    $ 3,049     $ 2,820  
Schedule of Accrued Liabilities [Table Text Block]
 
 
December 31,
 
 
 
20
15
 
 
2014
 
Accrued employee salaries and benefits
   $ 1,863     $ 719  
Accrued bonuses
     2,965       2,012  
Total accrued payroll and employee liabilities
   $ 4,828     $ 2,731  
 
 
December 31,
 
 
 
2015
 
 
2014
 
Accrued consulting and professional fees
   $ 3,914     $ 1,775  
Accrued accounts payable
     36       886  
Deferred rent
     61       105  
Other accrued liabilities
     143       165  
Total other accrued expense
   $ 4,154     $ 2,931