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Note 10 - Summary of Quarterly Consolidated Financial Data (Unaudited) (Tables)
 12 Months Ended
Dec. 31, 2015
Notes Tables  
Schedule of Quarterly Financial Information [Table Text Block]
 
 
2015
 
 
 
First
Quarter
 
 
Second
Quarter
 
 
Third
Quarter
 
 
Fourth
Quarter
 
 
 
(In thousands, except per share amounts)
 
Operating expenses:
                                
Research and development
   $ 14,504     $ 16,175     $ 14,241     $ 16,263  
General and administrative
     5,856       6,839       8,250       14,797  
Loss from operations
     (20,360
)
     (23,014
)
     (22,491
)
     (31,060
)
Interest income
     22       26       61       65  
Interest expense
     (232
)
     (237
)
     (242
)
     (247
)
Other expense
     —       118       —       —  
Net loss
   $ (20,570
)
   $ (23,107
)
   $ (22,672
)
   $ (31,242
)
Basis and diluted net loss per share
   $ (0.70
)
   $ (0.74
)
   $ (0.63
)
   $ (0.87
)
 
 
2014
 
 
 
First
Quarter
 
 
Second
Quarter
 
 
Third
Quarter
 
 
Fourth
Quarter
 
 
 
(In thousands, except per share amounts)
 
Operating expenses:
                                
Research and development
   $ 11,628     $ 14,279     $ 14,731     $ 14,195  
General and administrative
     5,694       4,512       4,222       5,300  
Loss from operations
     (17,322
)
     (18,791
)
     (18,953
)
     (19,495
)
Interest income
     —       —       —       3  
Interest expense
     (216
)
     (220
)
     (224
)
     (227
)
Other expense
     —       —       (17
)
     (905
)
Net loss
   $ (17,538
)
   $ (19,011
)
   $ (19,194
)
   $ (20,624
)
Basis and diluted net loss per share
   $ (0.74
)
   $ (0.78
)
   $ (0.66
)
   $ (0.71
)