Percentage amount the holder would beneficially own of the company's outstanding common stock.

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Notice period associated with beneficial ownership percentage limitation, convertible notes.

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The purchase price of stock from 1997 Employee Stock Purchase Plan will be the lower of the closing price of common stock on: (i) the first trading day in the enrollment period, as defined in the Purchase Plan, in which the purchase is made, or (ii) the purchase date.

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Percent of eligible employees that participated in the 1997 Employee Stock Purchase Plan.

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Maximum percent employees can elect to withhold from their base earnings to purchase common stock.

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The weighted average fair value of per share prices paid for shares purchased on the open market for issuance to employees under the plan.

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Exercise price per share or per unit of warrants or rights outstanding.

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Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.

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Aggregate number of common shares reserved for future issuance.

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The maximum number of common shares permitted to be issued by an entity's charter and bylaws.

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Total number of common shares of an entity that have been sold or granted to shareholders (includes common shares that were issued, repurchased and remain in the treasury). These shares represent capital invested by the firm's shareholders and owners, and may be all or only a portion of the number of shares authorized. Shares issued include shares outstanding and shares held in the treasury.

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Unrecognized cost of unvested share-based compensation awards.

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Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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The cash outflow for cost incurred directly with the issuance of an equity security.

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The cash inflow from the additional capital contribution to the entity.

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The cash inflow from the issuance of common stock, preferred stock, treasury stock, stock options, and other types of equity.

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The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately.

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The cash inflow associated with the amount received from holders exercising their stock warrants.

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Per share amount received by subsidiary or equity investee for each share of common stock issued or sold in the stock transaction.

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Period which an employee's right to exercise an award is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Number of non-option equity instruments exercised by participants.

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Number of additional shares authorized for issuance under an established share-based compensation plan.

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The maximum number of shares (or other type of equity) originally approved (usually by shareholders and board of directors), net of any subsequent amendments and adjustments, for awards under the equity-based compensation plan. As stock or unit options and equity instruments other than options are awarded to participants, the shares or units remain authorized and become reserved for issuance under outstanding awards (not necessarily vested).

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Amount of accumulated difference between fair value of underlying shares on dates of exercise and exercise price on options exercised (or share units converted) into shares.

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Number of options or other stock instruments for which the right to exercise has lapsed under the terms of the plan agreements.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of share instruments newly issued under a share-based compensation plan.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options of the plan that expired.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options that were terminated.

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The number of shares reserved for issuance pertaining to the outstanding stock options as of the balance sheet date for all option plans in the customized range of exercise prices.

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Price of a single share of a number of saleable stocks of a company.

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Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Number of new stock issued during the period.

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Ratio applied to the conversion of stock split, for example but not limited to, one share converted to two or two shares converted to one.

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Note 7 - Stockholders' Equity (Details Textual)		1 Months Ended									12 Months Ended			68 Months Ended	97 Months Ended
Note 7 - Stockholders' Equity (Details Textual)	Jan. 13, 2014	Jun. 30, 2015 USD ($) $ / shares shares	May. 31, 2015 shares	Jun. 30, 2014 USD ($) $ / shares shares	May. 31, 2014 shares	Nov. 30, 2013 USD ($) $ / shares shares	Jun. 30, 2011 $ / shares shares	May. 31, 2010 shares	May. 31, 2009 shares	Dec. 31, 2007 shares	Dec. 31, 2015 USD ($) $ / shares shares	Dec. 31, 2014 USD ($) $ / shares shares	Dec. 31, 2013 USD ($) $ / shares shares	Dec. 31, 2015 USD ($) $ / shares shares	Dec. 31, 2015 USD ($) $ / shares shares	Sep. 13, 2013 shares	Sep. 12, 2013 shares
Private Placement 2011 [Member] \| Common Stock [Member]
Stock Issued During Period, Shares, New Issues											285,713	303,614
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Exercised											343,813	460,706
Private Placement 2011 [Member]
Proceeds from Warrant Exercises \| $											$ 0		$ 600,000
Class of Warrant or Right, Number of Securities Called by Warrants or Rights							4,000,000
Class of Warrant or Right, Exercise Price of Warrants or Rights \| $ / shares							$ 3.60
Beneficial Ownership after Conversion							9.99%
Notice Period Associated with Beneficial Ownership Percentage Limitation Convertible Notes							61 days
Reverse Stock Split [Member]
Stockholders' Equity Note, Stock Split, Conversion Ratio	20
Common Stock [Member]
Stock Issued During Period, Shares, New Issues		5,500,000		4,800,000		7,700,000
Sale of Stock, Price Per Share \| $ / shares		$ 24.75		$ 11.75		$ 8
Proceeds from Issuance of Common Stock \| $						$ 57,800,000
Payments of Stock Issuance Costs \| $		$ 8,400,000				$ 3,900,000
Proceeds from Issuance or Sale of Equity \| $		$ 128,200,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period											1,042,000	588,000	537,000
Common Stock and Prefunded Warrants [Member]
Payments of Stock Issuance Costs \| $				$ 4,000,000
Proceeds from Issuance or Sale of Equity \| $				$ 58,900,000
Pre-funded Warrants[Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights				600,000
Share Price \| $ / shares				$ 11.74
Class of Warrant or Right, Exercise Price of Warrants or Rights \| $ / shares				$ 0.01
Weighted Average [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights \| $ / shares												$ 3
Employee Stock Purchase Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized			100,000		25,000		25,000		10,000	5,000					175,000
Share-based Compensation Arrangement by Share-based Payment Award Maximum Employee Earnings with held to Purchase Common Stock Percent											10.00%
Share-based Compensation Arrangement by Share-based Payment Award Discount on Stock Price												85.00%
Share-based Compensation Arrangement by Share-based Payment Award Eligible Participants Percent											36.00%
Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period											30,361	12,028	5,630
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price \| $ / shares											$ 8.46	$ 7.59	$ 6.12
Common Stock, Shares, Issued											75,468			75,468	75,468
Common Stock, Capital Shares Reserved for Future Issuance											99,532			99,532	99,532
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value \| $ / shares											$ 21.92	7.40	6.53
Share-based Compensation Arrangement by Share-based Payment Award, Per Share Weighted-average Fair Value Price of Shares Purchased \| $ / shares											$ 8.23	$ 3.06	$ 3.01	$ 8.23	$ 8.23
Equity Incentive Plan 2007 [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized			4,300,000		1,750,000		4,500,000	100,000						10,800,000
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized										150,000
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant											3,880,849			3,880,849	3,880,849
Proceeds from Warrant Exercises \| $													$ 600,000
Common Stock, Shares Authorized											75,000,000	75,000,000		75,000,000	75,000,000	75,000,000	1,500,000,000
Class of Warrant or Right, Number of Securities Called by Warrants or Rights											3,565,477			3,565,477	3,565,477
Proceeds from Issuance or Sale of Equity \| $											$ 128,199,000	$ 58,916,000	$ 57,802,000
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price \| $ / shares											$ 9.15	$ 6.34
Common Stock, Shares, Issued											36,106,000	29,227,000		36,106,000	36,106,000
Common Stock, Capital Shares Reserved for Future Issuance											23,067,406			23,067,406	23,067,406
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant											3,880,849			3,880,849	3,880,849
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period											10 years
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period											4 years
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period											1,042,343	756,593	537,029
Proceeds from Stock Options Exercised \| $											$ 9,535,000	$ 3,101,000	$ 2,793,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period											503,343
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price \| $ / shares											$ 9.16
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period											71,835
Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price \| $ / shares											$ 19.24
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term											6 years 255 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value \| $											$ 13,882,000	3,377,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value \| $											$ 46,603,000	$ 14,654,000		$ 46,603,000	$ 46,603,000
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Number of Outstanding Options											8,434,988			8,434,988	8,434,988
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized \| $											$ 63,865,000			$ 63,865,000	$ 63,865,000
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition											2 years 109 days