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Consolidated Statements of Comprehensive Loss - USD ($)
shares in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Operating expenses:      
Research and development $ 61,183,000 $ 54,833,000 $ 32,516,000
General and administrative 35,742,000 19,728,000 21,941,000
Total operating expenses 96,925,000 74,561,000 54,457,000
Loss from operations (96,925,000) (74,561,000) (54,457,000)
Other income (expense):      
Interest expense (958,000) (887,000) (828,000)
Other income (expense), net 292,000 (919,000) 2,000
Total other expense (666,000) (1,806,000) (826,000)
Net loss (97,591,000) (76,367,000) (55,283,000)
Other comprehensive loss:      
Unrealized losses on short-term investments (40,000) 0 0
Comprehensive loss $ (97,631,000) $ (76,367,000) $ (55,283,000)
Basic and diluted net loss per share (in dollars per share) $ (2.95) $ (2.87) $ (3.42)
Shares used in computing basic and diluted net loss per share (in shares) 33,081 26,569 16,163