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Note 8 - Income Taxes (Details Textual) - USD ($)
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Domestic Tax Authority [Member] | Stock Compensation Plan [Member]      
Operating Loss Carryforwards $ 4,235,000    
Domestic Tax Authority [Member]      
Operating Loss Carryforwards 242,769,000    
Deferred Tax Assets, Tax Credit Carryforwards, Research 7,434,000    
State and Local Jurisdiction [Member] | Stock Compensation Plan [Member]      
Operating Loss Carryforwards 4,235,000    
State and Local Jurisdiction [Member]      
Operating Loss Carryforwards 233,305,000    
Deferred Tax Assets, Tax Credit Carryforwards, Research 5,639,000    
Income Tax Expense (Benefit) 0 $ 0 $ 0
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued 0 0  
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount 40,445,000 32,035,000  
Deferred Tax Assets, Tax Credit Carryforwards, Research $ 11,181,000 7,667,000  
Unrecognized Tax Benefits that Would Impact Effective Tax Rate   120,000  
Unrecognized Tax Benefits   $ 120,000