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Consolidated Statements of Stockholders' Equity - USD ($)
Note Warrant [Member]
Common Stock [Member]
Note Warrant [Member]
Additional Paid-in Capital [Member]
Note Warrant [Member]
Retained Earnings [Member]
Note Warrant [Member]
Common Stock [Member]
Additional Paid-in Capital [Member]
AOCI Attributable to Parent [Member]
Retained Earnings [Member]
Total
Balance (in shares) at Dec. 31, 2012         15,111,000        
Balance at Dec. 31, 2012         $ 152,000 $ 235,253,000 $ (183,587,000) $ 51,818,000
Issuance of common stock in a public offering, net (in shares)         7,706,000        
Issuance of common stock in a public offering, net $ 2,000 $ 598,000 $ 600,000 $ 77,000 57,725,000   57,802,000
Conversion benefit included in Convertible Notes issued         291,000   291,000
Issuance of common stock under Employee Stock Purchase Plan (in shares)         6,000        
Issuance of common stock under Employee Stock Purchase Plan         $ 1,000 33,000   $ 34,000
Issuance of common stock upon exercise of stock options (in shares)         537,000       537,029
Issuance of common stock upon exercise of stock options         $ 5,000 2,788,000   $ 2,793,000
Issuance of common stock upon exercise of warrants (in shares) 212,000                
Stock-based compensation expense         10,890,000   10,890,000
Net loss             $ (55,283,000) (55,283,000)
Balance (in shares) at Dec. 31, 2013         23,572,000        
Balance at Dec. 31, 2013         $ 237,000 307,578,000 $ (238,870,000) 68,945,000
Issuance of common stock upon exercise of stock options         $ 5,000 2,788,000   2,793,000
Net unrealized loss on short-term investments                 0
Comprehensive loss                 (55,283,000)
Issuance of common stock in a public offering, net $ 3,000 (3,000)              
Conversion benefit included in Convertible Notes issued           309,000   309,000
Issuance of common stock under Employee Stock Purchase Plan (in shares)         12,000        
Issuance of common stock under Employee Stock Purchase Plan           91,000   $ 91,000
Issuance of common stock upon exercise of stock options (in shares)         588,000       756,593
Issuance of common stock upon exercise of stock options         $ 5,000 3,096,000   $ 3,101,000
Issuance of common stock upon exercise of warrants (in shares) 304,000                
Stock-based compensation expense           8,067,000   8,067,000
Net loss             $ (76,367,000) (76,367,000)
Balance (in shares) at Dec. 31, 2014         29,227,000        
Balance at Dec. 31, 2014         $ 292,000 378,007,000 $ (315,237,000) 63,062,000
Issuance of common stock and pre-funded warrants in a public offering, net (in shares)         4,751,000        
Issuance of common stock and pre-funded warrants in a public offering, net         $ 47,000 58,869,000   58,916,000
Issuance of common stock in a public offering, net         47,000 58,869,000   58,916,000
Issuance of common stock upon exercise of stock options         $ 5,000 3,096,000   3,101,000
Net unrealized loss on short-term investments                 0
Comprehensive loss                 (76,367,000)
Issuance of common stock in a public offering, net (in shares)         5,520,000        
Issuance of common stock in a public offering, net $ 3,000 $ (3,000)              
Conversion benefit included in Convertible Notes issued           328,000   328,000
Issuance of common stock under Employee Stock Purchase Plan (in shares)         31,000        
Issuance of common stock under Employee Stock Purchase Plan           257,000   $ 257,000
Issuance of common stock upon exercise of stock options (in shares)         1,042,000       1,042,343
Issuance of common stock upon exercise of stock options         $ 11,000 9,524,000   $ 9,535,000
Issuance of common stock upon exercise of warrants (in shares) 286,000                
Stock-based compensation expense           14,360,000   14,360,000
Net loss             $ (97,591,000) (97,591,000)
Balance (in shares) at Dec. 31, 2015         36,106,000        
Balance at Dec. 31, 2015         $ 361,000 530,617,000 $ (40,000) $ (412,828,000) 118,110,000
Issuance of common stock and pre-funded warrants in a public offering, net         55,000 128,144,000   128,199,000
Issuance of common stock in a public offering, net         55,000 128,144,000   128,199,000
Issuance of common stock upon exercise of stock options         $ 11,000 $ 9,524,000   9,535,000
Net unrealized loss on short-term investments             $ (40,000) (40,000)
Comprehensive loss             $ (97,631,000)