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Note 10 - Summary Quarterly Results of Operations (Details) - USD ($)
 3 Months Ended
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2014
Sep. 30, 2014
Jun. 30, 2014
Mar. 31, 2014
Operating expenses:                
Research and development $ 16,263,000 $ 14,241,000 $ 16,175,000 $ 14,504,000 $ 14,195,000 $ 14,731,000 $ 14,279,000 $ 11,628,000
General and administrative 14,797,000 8,250,000 6,839,000 5,856,000 5,300,000 4,222,000 4,512,000 5,694,000
Loss from operations (31,060,000) (22,491,000) (23,014,000) (20,360,000) (19,495,000) $ (18,953,000) $ (18,791,000) $ (17,322,000)
Interest income 65,000 61,000 26,000 22,000 3,000
Interest expense $ (247,000) $ (242,000) (237,000) $ (232,000) (227,000) $ (224,000) $ (220,000) $ (216,000)
Other expense 118,000 (905,000) (17,000)
Net loss $ (31,242,000) $ (22,672,000) $ (23,107,000) $ (20,570,000) $ (20,624,000) $ (19,194,000) $ (19,011,000) $ (17,538,000)
Basis and diluted net loss per share (in dollars per share) $ (0.87) $ (0.63) $ (0.74) $ (0.70) $ (0.71) $ (0.66) $ (0.78) $ (0.74)