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Note 6 - Stockholders' Equity (Tables)

3 Months Ended

Mar. 31, 2016

Notes Tables

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

		Three Months Ended March 31 ,
		2016				2015
Research and development		$	2,073			$	806
General and administrative			1,667				1,002
Sales and marketing			1,615				743
Stock-based compensation expense included in operating expenses		$	5,355			$	2,551
Impact on basic and diluted net loss per share		$	0.15			$	0.09

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		March 31,
		20 16				20 15
Risk-free interest rate			1.6	%			1.6	%
Dividend yield			0.0	%			0.0	%
Volatility			90.6	%			91.7	%
Expected life (years)			6				6

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

		Shares (in thousands)				Weighted- Average Exercise Price				Weighted- Average Remaining Contractual Term (Years)
Balance at January 1, 2016			8,435			$	13.64				7.94
Granted			925			$	20.80
Exercised			(243	)		$	10.41
Expired and forfeited			(156	)		$	23.61
Balance at March 31, 2016			8,961			$	14.30				8.06

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- Definition

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