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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Operating activities:    
Net loss $ (33,445,000) $ (20,570,000)
Adjustments to reconcile net loss to net cash used for operating activities:    
Stock-based compensation expense 5,355,000 2,551,000
Depreciation and amortization 238,000 152,000
Amortization of Debt Discount (Premium) 166,000 $ 151,000
Amortization of premium on short-term investments 145,000
Changes in operating assets and liabilities:    
Inventory (2,744,000)
Prepaid expenses and other assets (1,420,000) $ 112,000
Accounts payable 3,561,000 (166,000)
Accrued clinical liabilities (1,496,000) (293,000)
Accrued payroll and employee-related liabilities (1,859,000) (1,075,000)
Other accrued liabilities (852,000) (531,000)
Net cash used for operating activities (32,351,000) $ (19,669,000)
Investing activities:    
Maturities of short-term investments 23,491,000
Purchases of property and equipment (834,000) $ (328,000)
Net cash provided by (used for) investing activities 22,657,000 (328,000)
Financing activities:    
Proceeds from stock option exercises 2,530,000 2,878,000
Net cash provided by financing activities 2,530,000 2,878,000
Net decrease in cash and cash equivalents (7,164,000) (17,119,000)
Cash and cash equivalents at beginning of period 75,180,000 72,675,000
Cash and cash equivalents at end of period $ 68,016,000 $ 55,556,000