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Note 6 - Stockholders' Equity (Tables)

6 Months Ended

Jun. 30, 2016

Notes Tables

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

										Weighted-
										Average
						Weighted-				Remaining
						Average				Contractual
		Shares				Exercise				Term
		(in thousands)				Price				(Years)
Balance at January 1, 2016			8,435			$	13.64				7.94
Granted			1,080			$	20.76
Exercised			(531	)		$	8.96
Expired and forfeited			(237	)		$	24.81
Balance at June 30, 2016			8,747			$	14.50				7.91

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

		Three Months Ended June 30 ,								Six Months Ended June 30,
		2016				2015				2016				2015
Research and development		$	2,329			$	919			$	4,402			$	1,725
General and administrative			1,798				1,470				3,465				2,472
Sales and marketing			1,704				752				3,319				1,494
Stock-based compensation expense included in operating expenses		$	5,831			$	3,141			$	11,186			$	5,691
Impact on basic and diluted net loss per share		$	0.16			$	0.10			$	0.31			$	0.19

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		June 30,
		20 16				20 15
Risk-free interest rate			1.5	%			1.7	%
Dividend yield			0.0	%			0.0	%
Volatility			90.6	%			91.0	%
Expected life (years)			6				6

Schedule of Share-based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block]

		June 30,
		20 16				20 15
Risk-free interest rate			0.4	%			0.1	%
Dividend yield			0.0	%			0.0	%
Volatility			85.1	%			59.1	%
Expected life (months)			6				6

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