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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Operating activities:    
Net loss $ (76,671,000) $ (43,677,000)
Adjustments to reconcile net loss to net cash used for operating activities:    
Stock-based compensation expense 11,186,000 5,691,000
Depreciation and amortization 489,000 323,000
Amortization of Debt Discount (Premium) 336,000 305,000
Amortization of premium on short-term investments 196,000
Gain on disposal of property and equipment (118,000)
Changes in operating assets and liabilities:    
Inventory (3,312,000)
Prepaid expenses and other assets 325,000 (838,000)
Accounts payable 5,361,000 438,000
Accrued clinical liabilities 4,254,000 2,531,000
Accrued payroll and employee-related liabilities (154,000) (447,000)
Other accrued liabilities (1,471,000) 304,000
Net cash used for operating activities (59,461,000) (35,488,000)
Investing activities:    
Maturities of short-term investments 43,129,000
Purchases of property and equipment (1,911,000) (531,000)
Proceeds from sale of property and equipment 241,000
Net cash provided by (used for) investing activities 41,218,000 (290,000)
Financing activities:    
Proceeds from purchases under the Employee Stock Purchase Plan 251,000 118,000
Proceeds from stock option exercises 4,755,000 6,306,000
Net proceeds from sale of common stock 128,205,000
Net cash provided by financing activities 5,006,000 134,629,000
Net (decrease) increase in cash and cash equivalents (13,237,000) 98,851,000
Cash and cash equivalents at beginning of period 75,180,000 72,675,000
Cash and cash equivalents at end of period $ 61,943,000 $ 171,526,000