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v3.5.0.2

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 9 Months Ended
--- | ---
Sep. 30, 2016 | Sep. 30, 2015
Operating activities: |  |
Net loss | $ (125,180,000) | $ (66,349,000)
Adjustments to reconcile net loss to net cash used for operating activities: |  |
Stock-based compensation expense | 18,697,000 | 8,512,000
Depreciation and amortization | 793,000 | 498,000
Amortization of Debt Discount (Premium) | 510,000 | 463,000
Amortization of premium on short-term investments | 219,000 |
Gain on disposal of property and equipment |  | (118,000)
Changes in operating assets and liabilities: |  |
Inventory | (1,983,000) |
Prepaid expenses and other assets | 428,000 | (993,000)
Accounts payable | 2,790,000 | 186,000
Accrued clinical liabilities | 4,608,000 | 1,356,000
Accrued payroll and employee-related liabilities | 3,813,000 | 658,000
Other accrued liabilities | (271,000) | 411,000
Net cash used for operating activities | (95,576,000) | (55,376,000)
Investing activities: |  |
Purchases of short-term investments | (43,318,000) |
Maturities of short-term investments | 55,829,000 |
Purchases of property and equipment | (2,446,000) | (783,000)
Proceeds from sale of property and equipment |  | 241,000
Net cash provided by (used for) investing activities | 10,065,000 | (542,000)
Financing activities: |  |
Proceeds from purchases under the Employee Stock Purchase Plan | 251,000 | 118,000
Proceeds from stock option exercises | 5,720,000 | 7,915,000
Proceeds from issuance of promissory note payable | 50,000,000 |
Net proceeds from sale of common stock |  | 128,199,000
Net cash provided by financing activities | 55,971,000 | 136,232,000
Net (decrease) increase in cash and cash equivalents | (29,540,000) | 80,314,000
Cash and cash equivalents at beginning of period | 75,180,000 | 72,675,000
Cash and cash equivalents at end of period | 45,640,000 | 152,989,000
Supplemental disclosure of cash flow information: |  |
Interest paid | $ 622,000 |

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