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Note 9 - Subsequent Events	9 Months Ended
Note 9 - Subsequent Events	Sep. 30, 2016
Notes to Financial Statements
Subsequent Events [Text Block]	9 . Subsequent Events On October 18, 2016, we entered into a lease (the “Lease”) with AP3-SD1 Campus Point LLC (the “Landlord”) pursuant to which we will lease office and laboratory space in the building located at 4242 Campus Point Court, San Diego, California for a period of seven years and four and one-half months, beginning on or about December 1, 2016. Pursuant to the Lease, we have agreed to pay a basic annual rent that rises incrementally over the term of the lease from $1.3 million for the first 12 months of the Lease to a prorated portion of $1.6 million for the last four and one-half months of the Lease, and such other amounts as set forth in the Lease. We also paid to the Landlord a security deposit of $0.1 million. The Lease provides us with an option to renew the Lease for an additional five year term. Pursuant to the Lease, the Landlord has granted us a one-time right of first refusal during the term of the Lease with respect to certain additional office and laboratory space in the same building. The Lease contains customary default provisions, representations, warranties and covenants.